Undifferentiated carcinoma with lymphoid stroma of the parotid gland

Dündar, Ahmet; Dereköy, Sefa; Önder, Turgut; Aktaş, Davut; Özünlü, Adnan

doi:10.1017/s0022215100125617

J. Laryngol. Otol.

1993

DOI: 10.1017/s0022215100125617

|View full text |Cite

Undifferentiated carcinoma with lymphoid stroma of the parotid gland

Ahmet Dündar

Sefa Dereköy

Turgut Önder

et al.

Abstract: A rare undifferentiated carcinoma with lymphoid stroma (UCLS) of the parotid gland is described in a white Turkish patient. The raised serum IgG to Epstein-Barr virus capsid antigen suggests a causal relationship between Epstein-Barr virus and this type of salivary gland carcinoma. Some clinical features are briefly reviewed.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1997

2021

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the first report by Hilderman et al in 1962,1 about 120 cases of undifferentiated carcinoma of the major salivary glands have been reported in the literature. The incidence is relatively high among the Inuit of North America and Greenland and the southern Chinese 2‐25. Epstein‐Barr virus (EBV) has been demonstrated to be closely related to these tumors by several authors 10, 15, 20, 23, 24, 26, 27.…”

mentioning

confidence: 99%

Undifferentiated carcinoma of the major salivary glands

Sheen

Tsai

et al. 1997

Cancer

View full text Add to dashboard Cite

BACKGROUND Undifferentiated carcinoma of the salivary glands is a rare disease, the incidence of which is highest among the Inuit of Greenland and North America. It was demonstrated to be closely related to Epstein‐ Barr virus (EBV) infection. However, the relation of EBV to this tumor has not been studied to any great extent here in Taiwan because of the small number of cases. METHODS Twelve cases of undifferentiated carcinoma of the salivary glands from the period 1977‐1996 were retrieved from the cancer registry at National Taiwan University Hospital. The clinical data were analyzed retrospectively based on the medical records. Eleven formalin fixed, paraffin embedded tissue sections were used for in situ hybridization with an antisense probe complementary to EBV‐encoded RNA 1 (EBER1). RESULTS Ten of 12 tumors originated from the parotid gland and 2 from the submandibular gland. The patients' ages ranged from 22 to 63 years, with an average of 38.1 years. One patient was lost to follow‐up, 2 patients died of metastatic disease, and the remaining 9 patients were all alive and disease free at last follow‐up. The actuarial 5‐year survival rate was 79.8%. In situ hybridization demonstrated EBER1 in 9 of the undifferentiated carcinomas with lymphoid stroma, but EBER1 was not demonstrated in the other 2 tumors without lymphoid stroma. CONCLUSIONS Undifferentiated carcinoma with lymphoid stroma of the major salivary glands is closely associated with EBV. The mainstay of treatment is surgery and postoperative radiotherapy. The outcomes in this series were good except for two elderly patients who died of rapid and progressive distant metastases. Cancer 1997; 80:357‐63. © 1997 American Cancer Society.

show abstract

mentioning

confidence: 99%

Undifferentiated carcinoma of the major salivary glands

Sheen

Tsai

et al. 1997

Cancer

View full text Add to dashboard Cite

show abstract

Lymphoepithelial Carcinoma of Salivary Glands

Thompson

Whaley

2021

Surgical Pathology Clinics

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Undifferentiated carcinoma with lymphoid stroma of the parotid gland

Cited by 2 publications

References 7 publications

Undifferentiated carcinoma of the major salivary glands

Undifferentiated carcinoma of the major salivary glands

Lymphoepithelial Carcinoma of Salivary Glands

Contact Info

Product

Resources

About