Understanding zebrafish aggressive behavior

Zabegalov, Konstantin N.; Колесникова, Т. А.; Khatsko, Sergey L.; Volgin, Andrey D.; Yakovlev, Oleg A.; Amstislavskaya, Tamara G.; Friend, Ashton J.; Bao, Wandong; Alekseeva, Polina A.; Lakstygal, Anton M.; Meshalkina, Darya A.; Demin, Konstantin A.; Abreu, Murilo S. de; Rosemberg, Denis B.; Kalueff, Allan V.

doi:10.1016/j.beproc.2018.11.010

Cited by 66 publications

(45 citation statements)

References 180 publications

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“…Furthermore, ICDs involve various phenotypes (Figure 2) that can be studied in zebrafish using pharmacological, pharmacogenetic and pharmacogenomic approaches (de Abreu, et al., 2019; Zabegalov et al., 2019). Impulsive behaviors are also associated with sex‐specific ICD‐like traits that can also be targeted in zebrafish (Genario, de Abreu, Giacomini, Demin, & Kalueff, 2019).…”

Section: Zebrafish Model Of Impulsivity and Icdsmentioning

confidence: 99%

“…Complementing rodent findings, the zebrafish ( Danio rerio ) is rapidly emerging as an important model organism to study impulsive (Parker, Ife, et al, 2013) and aggressive behaviors (de Abreu, et al., 2019; Gerlai, Lahav, Guo, & Rosenthal, 2000; Zabegalov et al., 2019), both highly relevant to ICDs (Figure 2 and Table 2). Zebrafish possess fully sequenced genome with >70% homology to human genes (Howe et al., 2013), shared neurotransmitter systems, well‐conserved brain circuits (Stewart, Ullmann, et al, 2015) and a potential for high‐throughput in vivo drug screening (Li et al., 2017; Macrae & Peterson, 2015; Stewart, Gerlai, & Kalueff, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Zebrafish models of impulsivity and impulse control disorders

Abreu

Giacomini

Genário

et al. 2020

Eur J of Neuroscience

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Impulse control disorders (ICDs) are characterized by generalized difficulty controlling emotions and behaviors. ICDs are a broad group of the central nervous system (CNS) disorders including conduct disorder, intermittent explosive, oppositional‐defiant disorder, antisocial personality disorder, kleptomania, pyromania and other illnesses. Although they all share a common feature (aberrant impulsivity), their pathobiology is complex and poorly understood. There are also currently no ICD‐specific therapies to treat these illnesses. Animal models are a valuable tool for studying ICD pathobiology and potential therapies. The zebrafish (Danio rerio) has become a useful model organism to study CNS disorders due to high genetic and physiological homology to mammals, and sensitivity to various pharmacological and genetic manipulations. Here, we summarize experimental models of impulsivity and ICD in zebrafish and highlight their growing translational significance. We also emphasize the need for further development of zebrafish ICD models to improve our understanding of their pathogenesis and to search for novel therapeutic treatments.

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Section: Zebrafish Model Of Impulsivity and Icdsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Zebrafish models of impulsivity and impulse control disorders

Abreu

Giacomini

Genário

et al. 2020

Eur J of Neuroscience

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“…Displays are usually scored as the fish erecting its dorsal and anal fins and flaring its body flank toward the opponent. It is also possible to elicit aggressive displays by showing videos of conspecifics, evaluating aggressive behaviors (e.g., bites) and time spent in the area near the video stimulus (de Abreu et al, ; Way et al, ; Zabegalov et al, ). Although both models elicit aggressive displays in zebrafish, because the animal is unable to interact with the opponent, such aggressive behavior does not follow the usual escalation observed in natural contexts.…”

Section: Measuring Affective‐like Behavior In Crayfish and Zebrafishmentioning

confidence: 99%

“…After an overnight acclimation, the divider is removed, and the fish are left to interact for 30 min, which is usually sufficient to determine a clear winner. Behavioral patterns that can be observed include displays; circling (fish approach one another in opposite directions and with erected fins, and in an antiparallel position circle around each other usually ascending in the water column); strikes (fish swims rapidly toward the opponent but no physical contact occurs between them); bites (fish opens and closes its mouth in contact with the body surface of the opponent); chases (similar to strike behavior but with an active pursuit by the aggressor); retreats (fish swims rapidly away from the opponent in response to a strike or a bite); escapes (continued escape reaction in response to a chase); and freezing (fish stays immobile with all fins retracted) (de Abreu et al, ; Oliveira, Silva, & Simoes, ; Zabegalov et al, ).…”

Section: Measuring Affective‐like Behavior In Crayfish and Zebrafishmentioning

confidence: 99%

“…Analyses of zebrafish anxiety‐like (Egan et al, ; Maximino & Herculano, ), aggressive (Norton & Bally‐Cuif, ; Zabegalov et al, ) and social behaviors (Soares, Cardoso, Carvalho, & Maximino, ) strongly implicate the serotonergic system is modulating fish affective behaviors (Table ). This system is particularly relevant, because albeit not fully conserved in terms of neuroanatomy and genetics (Herculano & Maximino, ), it is functionally associated with emotional domains across vertebrates and invertebrates (Curran & Chalasani, ; Herculano & Maximino, ; Mohammad et al, ).…”

Section: Measuring Affective‐like Behavior In Crayfish and Zebrafishmentioning

confidence: 99%

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Emotional behavior in aquatic organisms? Lessons from crayfish and zebrafish

Abreu

Maximino

Banha

et al. 2019

J of Neuroscience Research

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Experimental animal models are a valuable tool to study the neurobiology of emotional behavior and mechanisms underlying human affective disorders. Mounting evidence suggests that various aquatic organisms, including both vertebrate (e.g., zebrafish) and invertebrate (e.g., crayfish) species, may be relevant to study animal emotional response and its deficits. Ideally, model organisms of disease should possess considerable genetic and physiological homology to mammals, display robust behavioral and physiological responses to stress, and should be sensitive to a wide range of drugs known to modulate stress and affective behaviors. Here, we summarize recent findings in the field of zebrafish‐ and crayfish‐based tests of stress, anxiety, aggressiveness and social preference, and discuss further perspectives of using these novel model organisms in translational biological psychiatry. Outlining the remaining questions in this field, we also emphasize the need in further development and a wider use of crayfish and zebrafish models to study the pathogenesis of affective disorders.

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Phenomics Approach to Investigate Behavioral Toxicity of Environmental or Occupational Toxicants in Adult Zebrafish (Danio rerio)

et al. 2021

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Over the last few years, environmental pollution, especially water pollution, has become a serious issue worldwide. Thus, methods that can help us understand the impact and effects of these pollutants, especially on aquatic animals, are needed. Behavioral assessment has emerged as a crucial tool in toxicology and pharmacology because many studies have shown, in multiple animal models, that various pharmacological compounds can alter behavior, with many of the findings being translatable to humans. Moreover, behavior study can also be used as a suitable indicator in the ecotoxicological risk assessment of pollutants. Several model organisms, especially rodent models, have been extensively employed for behavior studies. However, assessments using this model are generally time consuming, expensive, and require extensive facilities for housing experimental animals. Moreover, behavioral studies typically use different measurements and assessment tools, making comparisons difficult. In addition, even though behavioral phenomics has the potential to comprehensively illustrate the toxicities of chemicals, there is only a limited number of studies focusing on animal behavior using such a global approach. Here, we describe a phenomics approach that can be used to investigate the impact of pollutants using zebrafish. The approach consists of several behavioral tests, including response to a novel environment, mirror‐reflection image, predator fish, and conspecifics, after exposure to a test chemical. Phenotype fingerprinting, a method for summarizing individual phenotypes based on the results of the behavioral tests, is then conducted to reduce data complexity and display the pattern of each compound on behavioral phenotypes in zebrafish. This approach may be useful to researchers studying the potential adverse effects of different pollutants. © 2021 Wiley Periodicals LLC. Basic Protocol 1: Novel tank test Basic Protocol 2: Shoaling test Basic Protocol 3: Aggression test (mirror biting test) Basic Protocol 4: Social interaction test Basic Protocol 5: Fear response test Basic Protocol 6: PCA and heatmap clustering

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Understanding zebrafish aggressive behavior

Cited by 66 publications

References 180 publications

Zebrafish models of impulsivity and impulse control disorders

Zebrafish models of impulsivity and impulse control disorders

Emotional behavior in aquatic organisms? Lessons from crayfish and zebrafish

Phenomics Approach to Investigate Behavioral Toxicity of Environmental or Occupational Toxicants in Adult Zebrafish (Danio rerio)

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