Understanding the photothermal heating effect in non-lamellar liquid crystalline systems, and the design of new mixed lipid systems for photothermal on-demand drug delivery

Fong, Wye Khay; Hanley, Tracey; Thierry, Benjamin; Tilley, Adam John; Kirby, Nigel; Waddington, Lynne J.; Boyd, Ben J.

doi:10.1039/c4cp03635b

Cited by 29 publications

(23 citation statements)

References 116 publications

(249 reference statements)

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“…Drug release from V 2 phase and H 2 phases has been well established and it is known that release from the bicontinuous cubic phase with generally larger open water channels is more rapid than hexagonal phase (Fong et al, 2009(Fong et al, , 2014Lee et al, 2009). Phan et al studied the release of glucose, a small molecule, from the bicontinuous cubic phase and hexagonal phase and showed diffusion coefficients of D = 3.6 Â 10 À8 cm 2 s À1 and D = 1.7 Â 10 À8 cm 2 s À1 respectively (Phan et al, 2011).…”

Section: Discussionmentioning

confidence: 98%

Tailoring liquid crystalline lipid nanomaterials for controlled release of macromolecules

Bisset

Boyd

Dong

2015

International Journal of Pharmaceutics

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Section: Discussionmentioning

confidence: 98%

Tailoring liquid crystalline lipid nanomaterials for controlled release of macromolecules

Bisset

Boyd

Dong

2015

International Journal of Pharmaceutics

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“…Among the various inorganic (e.g., metal and carbon nanomaterials) and organic (e.g., indocyanine green and polyaniline) photothermal agents, gold nanoparticles and graphene have attracted particular attention due to their high photothermal conversion efficiency as well as their NIR-absorbing spectra, which make them extraordinarily popular in biological applications [277][278][279][280]. Remote manipulation of LCs through the photothermal effects induced by particular nanomaterials is an emerging field of promising materials [281][282][283][284][285]. The functional nanoparticle-LC composites are driven by light when the photothermal nanomaterial absorbs the light energy and converts it into heat, leading to a local increase in temperature.…”

Section: Photonic Applicationsmentioning

confidence: 99%

Perspectives in Liquid-Crystal-Aided Nanotechnology and Nanoscience

2019

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The research field of liquid crystals and their applications is recently changing from being largely focused on display applications and optical shutter elements in various fields, to quite novel and diverse applications in the area of nanotechnology and nanoscience. Functional nanoparticles have recently been used to a significant extent to modify the physical properties of liquid crystals by the addition of ferroelectric and magnetic particles of different shapes, such as arbitrary and spherical, rods, wires and discs. Also, particles influencing optical properties are increasingly popular, such as quantum dots, plasmonic, semiconductors and metamaterials. The self-organization of liquid crystals is exploited to order templates and orient nanoparticles. Similarly, nanoparticles such as rods, nanotubes and graphene oxide are shown to form lyotropic liquid crystal phases in the presence of isotropic host solvents. These effects lead to a wealth of novel applications, many of which will be reviewed in this publication. the observation of chirality from achiral molecules, resulting from sterically induced packing of the bent-core mesogens [10], such as ferroelectricity or the formation of helical superstructures in the B7 phase [14]. Thermotropic LCs are commonly constituted by single organic entities or mixtures thereof, which exhibit various mesophases at different temperatures or pressures [15], illustrated in Figure 1b. As the temperature rises, a typical thermotropic LC passes through higher ordered phases, also called soft crystals, the hexatic smectic phases with positional order as well as bond orientational order, through the fluid smectic phases (SmC and SmA), which exhibit both positional and orientational order, and finally to the nematic phase (N) with purely orientational order, into the isotropic phase. The number of different phases observed depends on the chemical composition, symmetry and order of the LC molecules. About 25 different thermotropic phases are known to date, and they are still increasing in number. Appl. Sci. 2019, 9, x FOR PEER REVIEW 2 of 47 unique effects of the observation of chirality from achiral molecules, resulting from sterically induced packing of the bent-core mesogens [10], such as ferroelectricity or the formation of helical superstructures in the B7 phase [14]. Thermotropic LCs are commonly constituted by single organic entities or mixtures thereof, which exhibit various mesophases at different temperatures or pressures [15], illustrated in Figure 1b. As the temperature rises, a typical thermotropic LC passes through higher ordered phases, also called soft crystals, the hexatic smectic phases with positional order as well as bond orientational order, through the fluid smectic phases (SmC and SmA), which exhibit both positional and orientational order, and finally to the nematic phase (N) with purely orientational order, into the isotropic phase. The number of different phases observed depends on the chemical composition, symmetry and order of the LC molecules. About...

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“…Fong et al further undertook studies to understand the role of photothermal effect in nonlamellar LC systems . They set out to reveal the photothermal response of known and new lamellar and nonlamellar lyotropic phases by correlating the thermal properties of the materials and the photothermal energy conversion by the photothermal agent.…”

Section: Liquid Crystals Driven By Photothermal Effectmentioning

confidence: 99%

Soft Materials Driven by Photothermal Effect and Their Applications

Bisoyi

Urbas

2018

Advanced Optical Materials

128

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Remote driving of functional hybrid soft materials for various applications is emerging as an enabling pursuit. Toward this end, soft materials driven by photothermal agents have been attracting tremendous attention from both fundamental science and technological applications points of view. These stimuli‐responsive materials combine the beneficial attributes of both classes of promising materials, i.e., soft materials and photothermal agents. Both inorganic and organic photothermal agents have been incorporated into the matrices of soft materials. Metal nanoparticles, carbon nanomaterials, and organic photothermal agents have been impregnated into the matrices of liquid crystals, polymers, and gels that can be remotely driven by light irradiation. In this review, the remote driving of functional hybrid soft materials and their various applications are discussed. Photothermal functional nanocomposites are demonstrated to act as actuators, therapeutic agents, drug delivery systems, microvalves, etc. Smart and adaptive systems are realized by dispersing photothermal agents into soft matter matrices. Challenges and opportunities in this fascinating frontier are outlined.

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Understanding the photothermal heating effect in non-lamellar liquid crystalline systems, and the design of new mixed lipid systems for photothermal on-demand drug delivery

Cited by 29 publications

References 116 publications

Tailoring liquid crystalline lipid nanomaterials for controlled release of macromolecules

Tailoring liquid crystalline lipid nanomaterials for controlled release of macromolecules

Perspectives in Liquid-Crystal-Aided Nanotechnology and Nanoscience

Soft Materials Driven by Photothermal Effect and Their Applications

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