Understanding the ECG. Part 8: myocardial ischaemia and infarction (part A)

Sampson, Michael

doi:10.12968/bjca.2016.11.6.290

Cited by 1 publication

(2 citation statements)

References 35 publications

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“…The results also indicated that GQDs‐PEG 10 and 20 reduced the amount of ST deviation that remained 2 weeks after MI. The Q wave emersion along with ST elevation after anterior MI is associated with an aneurysm, a left ventricular abnormal motion of the necrotic region 17 . The aneurysm stretches the surrounding active tissues, so it activates stretch‐dependent K ATP channels that produce injury currents and ST deviation 18–20 .…”

Section: Discussionmentioning

confidence: 99%

“…The Q wave emersion along with ST elevation after anterior MI is associated with an aneurysm, a left ventricular abnormal motion of the necrotic region. 17 The aneurysm stretches the surrounding active tissues, so it activates stretch-dependent K ATP channels that produce injury currents and ST deviation. [18][19][20] It was shown in patients with MI, the persistence of ST elevation is associated with cardiac microvascular damages.…”

Section: Discussionmentioning

confidence: 99%

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Beneficial effects of PEGylated graphene quantum dot on arrhythmias induced by myocardial infarction

Rostamzadeh

Najafipour

Jafarinejad-Farsangi

et al. 2021

Biotech and App Biochem

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Arrhythmias are one of the leading causes of early death following myocardial infarction (MI) and heart failure. Graphene derivatives have emerged as an therapeutic target that have electrical conductivity. The study aimed to evaluate the impacts of polyethylene glycol-graphene quantum dots (GQDs-PEG) on arrhythmias created by MI in the rat. Animals were randomly assigned to five groups of sham, MI, and MI + GQDs-PEG at doses of 5, 10, and 20 mg/kg. MI was induced by the closure of the left anterior descending artery. The day after MI, animals were administered vehicle (phosphate buffered saline) or GQDs-PEG at different doses every other day for 2 weeks. On day 15, electrocardiogram (ECG), mean arterial pressure (MAP), and heart contractility indices were recorded by the PowerLab data acquisition system. GQDs-PEG 20 mg/kg increased contractility and improved the reduction of MAP in the MI group. The prolonged QT and QTc intervals, inverted T wave, and deviated ST segment were modified by GQDs-PEG 10 and 20 mg/kg in rats with MI. The amplitude of the Q wave was also decreased in a dose-dependent manner in the GQDs-PEG-treated rats. The results demonstrated that 2 weeks of treatment with GQDs-PEG normalized ECG abnormalities and improved left ventricular dysfunction in rats with MI.

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Section: Discussionmentioning

confidence: 99%