Understanding microbeads stacking in deformable Nano-Sieve for Efficient plasma separation and blood cell retrieval

Chen, Xinye; Zhang, Shuhuan; Gan, Yu; Liu, Rui; Wang, Ruo‐Qian; Du, Ke

doi:10.1016/j.jcis.2021.08.119

Cited by 8 publications

(5 citation statements)

References 52 publications

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“…To explain the limited effect of the channel depth on capture efficiency, we investigated the deformation of a PDMS channel under an application of high pressure. It is well known that PDMS is an elastic polymer and highly deformable, 45 hence we supposed that the microslit channels could be deformed by introducing a pressure-driven flow. To evaluate the deformation and the change in the depth of the microslit channels by the application of a fluid sample, a fluorescent dye solution (0.2 mM sodium fluorescein in deionized water) was introduced into the microslit channels (depth 3.3 µm, length 8 mm), and the fluorescence intensities at the center position were measured by image processing software.…”

Section: Evaluation Of the Deformation Of Microslit Channelsmentioning

confidence: 99%

Process simplification and structure design of parallelized microslit isolator for physical property-based capture of tumor cells

Shimmyo

Furuhata

Yamada

et al. 2022

Analyst

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Section: Evaluation Of the Deformation Of Microslit Channelsmentioning

confidence: 99%

Process simplification and structure design of parallelized microslit isolator for physical property-based capture of tumor cells

Shimmyo

Furuhata

Yamada

et al. 2022

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“…In many biological and medical applications, the efficient separation of particles or cells based on microfluidic approaches provides a convenient, miniaturized, automated, and reliable method for disease diagnosis, − drug screening, , and cell analysis. − The microfluidic technology is also called lab-on-a-chip. Through the design of ingenious microchannel structures and actuators, the entire cell and particle separation process can be scaled down to a small chip.…”

Section: Introductionmentioning

confidence: 99%

Optimization Analysis of Particle Separation Parameters for a Standing Surface Acoustic Wave Acoustofluidic Chip

Han

Lei

et al. 2022

ACS Omega

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Microparticle separation technology is an important technology in many biomedical and chemical engineering applications from sample detection to disease diagnosis. Although a variety of microparticle separation techniques have been developed thus far, surface acoustic wave (SAW)-based microfluidic separation technology shows great potential because of its high throughput, high precision, and integration with polydimethylsiloxane (PDMS) microchannels. In this work, we demonstrate an acoustofluidic separation chip that includes a piezoelectric device that generates tilted-angle standing SAWs and a permanently bonded PDMS microchannel. We established a mathematical model of particle motion in the microchannel, simulated the particle trajectory through finite element simulation and numerical simulation, and then verified the validity of the model through acoustophoresis experiments. To improve the performance of the separation chip, the influences of particle size, flow rate, and input power on the particle deflection distance were studied. These parameters are closely related to the separation purity and separation efficiency. By optimizing the control parameters, the separation of micron and submicron particles under different throughput conditions was achieved. Moreover, the separation samples were quantitatively analyzed by digital light scattering technology and flow cytometry, and the results showed that the maximum purity of the separated particles was ∼95%, while the maximum efficiency was ∼97%.

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“…Polydimethylsiloxane (PDMS) is one of the most popular building materials for deformable microfluidics with the advantages such as high deformability, biocompatibility, and stability 14 . We recently showed that the mechanical properties of the PDMS-based deformable microfluidics enable controlled microparticle capture and release 15 . However, the past studies focused on the fluid-structure interaction in steady flows [16][17][18][19][20] .…”

Section: A Introductionmentioning

confidence: 99%

Understanding the Dynamics of Fluid-Structure Interaction with an Air Deflected Microfluidic Chip (ADMC)

Pas

Wang

et al. 2022

Preprint

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A deformable microfluidic system and a fluidic dynamic model have been successfully coupled to understand the dynamic fluid-structure interaction in transient flow, designed to understand the dentine hypersensitivity caused by hydrodynamic theory. The Polydimethylsiloxane thin sidewalls of the microfluidic chip are deformed with air pressure ranging from 50 to 500 mbar to move the liquid meniscus in the central liquid channel. The displacement is recorded and compared with our new theoretical model derived from the unsteady Bernoulli equation. We show that our theoretical model can well predict the ending point of the liquid displacement as well as the dynamics process, regardless of the wall thickness. Moreover, an overshooting and oscillation phenomenon is observed by reducing the friction factor by a few orders which could be the key to explain the dentine hypersensitivity caused by the liquid movement in the dentine tubules.

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Understanding microbeads stacking in deformable Nano-Sieve for Efficient plasma separation and blood cell retrieval

Cited by 8 publications

References 52 publications

Process simplification and structure design of parallelized microslit isolator for physical property-based capture of tumor cells

Process simplification and structure design of parallelized microslit isolator for physical property-based capture of tumor cells

Optimization Analysis of Particle Separation Parameters for a Standing Surface Acoustic Wave Acoustofluidic Chip

Understanding the Dynamics of Fluid-Structure Interaction with an Air Deflected Microfluidic Chip (ADMC)

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