Understanding In Vivo Chromatic Aberrations in Pseudophakic Eyes Using on Bench and Computational Approaches

Abstract

Diffractive multifocal intraocular lenses (IOLs) modulate chromatic aberration and reduce it at certain distances due to interactions between the refractive and diffractive chromatic components. However, the extent to which computer modeling and on bench measurements of IOL chromatic aberration translate to chromatic aberration in patients implanted with these multifocal IOLs (MIOLs) is not yet fully understood. In this study, we compare the chromatic difference of focus and longitudinal chromatic aberrations in pseudophakic patients implanted with different IOL designs (monofocal and trifocal IOLs) and materials (hydrophobic and hydrophilic), and compared them with predictions from computer eye models and on bench measurements with the same IOLs. Patient data consisted of results from 63 pseudophakic eyes reported in four different studies and obtained psychophysically in the visual testing channel of a custom-developed polychromatic adaptive optics system. Computational predictions were obtained using ray tracing on computer eye models, and modulation transfer function (MTF) on bench measurements on physical eye models. We found that LCA (in vivo/simulated) for far vision was 1.37 ± 0.08 D/1.19 D for monofocal hydrophobic, 1.21 ± 0.08 D/0.88 D for monofocal hydrophilic, 0.99 ± 0.06 D/1.19 D for MIOL hydrophobic, and 0.82 ± 0.05 D/0.88 D for MIOL hydrophilic. For intermediate and near vision, LCA (in vivo/simulated) was 0.67 ± 0.10 D/0.75 D and 0.23 ± 0.08 D/0.19 D for MIOL hydrophobic and 0.27 ± 0.15 D/0.38 D and 0.15 ± 0.15 D/−0.13 D for MIOL hydrophilic, respectively. In conclusion, computational ray tracing and on bench measurements allowed for evaluating in vivo chromatic aberration with different materials and designs for multifocal diffractive intraocular lenses.

Editorial to the Special Issue on “Ocular Imaging for Eye Care”

“…This Special Issue gathers contributions in these fields that emphasize eye care. A total of 12 articles are published in this issue, demonstrating the extraordinary progress in a variety of scenarios, from ocular image processing and artificial intelligence [1][2][3][4] to ocular lens design and characterization [5][6][7][8], and visual performance [9][10][11][12]. Half of the articles deal with ocular lens implants, which has been revealed to be a very active field in surgery [5][6][7]9,11,12].…”

“…Variations with eccentricity, accommodative demand, and illumination conditions are outlined. Vinas-Pena et al [11] present the chromatic difference in focus and longitudinal chromatic aberration in phakic and pseudophakic eyes implanted with different IOL designs and materials, obtained from computational ray-tracing, on-bench and in vivo measurements using a custom-developed polychromatic adaptive optics system. The results confirm that diffractive multifocal IOLs modulate chromatic aberration; the predicted data obtained by simulations in computer eye models show excellent agreement with the experimental data (on-bench and in vivo).…”

Influencia del comportamiento cromático de las lentes intraoculares en la función visual

“…Existe interés científico y clínico por conocer la incidencia del comportamiento de las LIOs difractivas con la longitud de onda sobre la propia aberración cromática del ojo -como diferencia cromática de potencia refractiva-y la función visual del paciente. Diversos autores han estudiado los cambios que experimenta la ACL del ojo al implantar una lente intraocular monofocal (Nagata et al, 1999;Pérez-Merino et al, 2013;Siedlecki et al, 2014) o multifocal (Vinas et al, 2020;Vinas et al, 2022) aunque otros efectos en la visión cromática debido al implante de este tipo de lentes -como la distribución de energía en función de la longitud de onda-han sido escasamente estudiados más allá del laboratorio óptico. El impacto del implante de estas lentes sobre la visión del paciente y su determinación mediante exámenes clínicos están todavía en fase muy incipiente.…”

“…Midieron la CDRx en cuarenta ojos implantados con una LIO de polimetilmetacrilato (PMMA) (número de Abbe 58) y 49 ojos con lentes acrílicas blandas (Acrysof) (número de Abbe 37) y determinaron que los ojos con lentes Acrysof implantadas tenían una CDRx mayor que los ojos con implante de PMMA (0,98D frente a 0,64D). Siedlecki et al (Siedlecki et al, 2014) Recientes estudios muestran el impacto del implante de una lente multifocal difractiva en la ACL del ojo (Vinas et al, 2020;Vinas et al, 2022). En el caso de las lentes que utilizan el orden cero de difracción para el foco de lejos, el desenfoque cromático debido a la potencia base de la lente (con ACL positiva) se suma a la ACL del ojo.…”

“…Recientes estudios muestran el impacto del implante de una lente multifocal difractiva en la ACL del ojo (Vinas et al, 2020;Vinas et al, 2022). Al incorporar una LIO difractiva en el ojo humano, si opera con el orden de difracción cero en el foco de lejos, el desenfoque cromático debido a la potencia base de la lente se suma a la ACL del ojo.…”