Understanding esophageal neurofibroma: A case series and systematic review

Samat, Sajjaad H.; Onyemkpa, Chibueze; Torabi, Mohammad R.; Oyasiji, Tolutope

doi:10.1016/j.ijscr.2020.10.031

Cited by 5 publications

(12 citation statements)

References 17 publications

(34 reference statements)

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“…2 Most laryngeal neurofibromas are associated with NF, 3 but most esophageal neurofibromas are solitary. 4 The mean age of the patients with esophageal solitary neurofibromas at the time of diagnosis was 52.7 years (range: 26-75 years), and there was no difference between the sexes. Lesions were located primarily in the mid to upper section of the esophagus.…”

Section: Discussionmentioning

confidence: 89%

“…Neurofibroma may be classified as part of NF or as a solitary lesion that occurs sporadically 2 . Most laryngeal neurofibromas are associated with NF, 3 but most esophageal neurofibromas are solitary 4 . The mean age of the patients with esophageal solitary neurofibromas at the time of diagnosis was 52.7 years (range: 26–75 years), and there was no difference between the sexes.…”

Section: Discussionmentioning

confidence: 99%

“…Immunohistochemical staining using S-100 is also useful for diagnosing neurofibromas, 1,4 but hematoxylin-eosin staining alone is usually ineffective. Although characteristic pathological findings of neurofibroma were present in some biopsy specimens in this case, it still took about 3 years before a pathological diagnosis was made.…”

Section: Discussionmentioning

confidence: 99%

“…While it is preferable to diagnose neurofibromas by biopsy to avoid excessive surgery, diagnosis with biopsy or fine needle aspiration is sometimes difficult. 4,10 There are no reports on the sensitivity of biopsies for the solitary neurofibromas in the hypopharynx and esophagus. In this case, such findings were detected in 72.7% of hypopharyngeal biopsied specimens and 33.3% of esophageal biopsied specimens.…”

Section: Discussionmentioning

confidence: 99%

“…The mean age of the patients with esophageal solitary neurofibromas at the time of diagnosis was 52.7 years (range: 26–75 years), and there was no difference between the sexes. Lesions were located primarily in the mid to upper section of the esophagus 4 . Benign esophageal tumors were found in 0.17% of autopsies, 5 and esophageal neurofibroma comprised only 1% of these tumors 6 .…”

Section: Discussionmentioning

confidence: 99%

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A case of multiple solitary neurofibromas located in the hypopharynx and cervical esophagus

et al. 2022

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A 50‐year‐old female was admitted to our hospital because of mild throat discomfort. Esophagogastroduodenoscopy demonstrated multiple 2–3 mm diameter whitish granules in her hypopharynx and cervical esophagus. Based on biopsy specimens, we considered the lesions to represent normal tissue or very mild mucosal dysplasia. However, S‐100 immunohistochemical staining 3 years later led to a diagnosis of multiple solitary neurofibromas located in the hypopharynx and cervical esophagus. Histological finding characteristics of neurofibroma were present in 72.7% of hypopharyngeal biopsy specimens and 33.3% of esophageal specimens. When diagnosing neurofibroma, it is important to perform biopsies at multiple locations and at different times and to enlist the cooperation of endoscopists and pathologists for immunohistochemical staining with S‐100.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A case of multiple solitary neurofibromas located in the hypopharynx and cervical esophagus

et al. 2022

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Endoscopic submucosal dissection for a rare cause of esophageal mass: Von Recklinghausen's neurofibromatosis

Wang,

Zhang,

Shi

et al. 2024

Endoscopy

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Video 1 Endoscopic submucosal dissection for a rare cause of esophageal mass: Von Recklinghausen's neurofibromatosis. ▶ Fig. 1 a Cutaneous manifestations of neurofibromatosis observed during physical examination. b Upper endoscopy showing a mass originating from the lower esophagus to the gastric cardia. c Hypoechoic, submucosally-originating mass with multiple anechoic projections into the esophageal cavity, as revealed by endoscopic ultrasound. d Complete removal of the mass via endoscopic submucosal dissection. e The resected specimen. f Histological analysis confirming the presence of neurofibromatosis.

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Intranodal Neurofibroma: A Case Report and Literature Review

Adams¹,

Huston²,

Lozeau

2022

The American Journal of Dermatopathology

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Purpose:To report a case of neurofibroma involving the lymph nodes and to perform a literature review on this topic.Observations:A 72-year-old woman with a history of neurofibromatosis and biopsy-proven malignant melanoma of the left forearm underwent wide local excision of the malignant lesion along with sentinel axillary lymph node biopsy. Histological examination of axillary nodes revealed diffuse neurofibromatosis within 2 lymph node capsules. A thorough review of the English literature pertaining to intranodal neurofibroma was performed by querying Google Scholar and PubMed. Only 5 cases of intranodal neurofibroma have been described until now.Conclusions and Importance:Neurofibroma involving the lymph nodes is rare and this is the first reported case that is shown to diffusely involve the intracapsular space. Furthermore, intranodal neurofibroma can represent a diagnostic pitfall in the evaluation of sentinel lymph nodes for metastatic melanoma.

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Understanding esophageal neurofibroma: A case series and systematic review

Abstract: Highlights EF should be considered when subepithelial tumor is associated with dysphagia. Preop diagnosis is enhanced by needle biopsy with IHC analysis. S100 was the most utilized IHC stain. Enucleation (39.3%) was the most common treatment. MIS treatment is feasible.

Cited by 5 publications

References 17 publications

A case of multiple solitary neurofibromas located in the hypopharynx and cervical esophagus

A case of multiple solitary neurofibromas located in the hypopharynx and cervical esophagus

Endoscopic submucosal dissection for a rare cause of esophageal mass: Von Recklinghausen's neurofibromatosis

Intranodal Neurofibroma: A Case Report and Literature Review

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