Underdiagnosis of cervical intraepithelial neoplasia (CIN) 2 or Worse Lesion in Women with a Previous Colposcopy-Guided Biopsy Showing CIN 1

Souza, Carlos André Scheler de; Discacciati, Michelle Garcia; d’Otavianno, Maria Gabriela; Traue, Markus; Andrade, Liliana Aparecida Lucci De Angelo; Zeferino, Luíz Carlos

doi:10.1055/s-0037-1599071

Cited by 4 publications

(2 citation statements)

References 23 publications

(35 reference statements)

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“…Un diagnóstico discordante entre la histología de la biopsia colposcópica debe llamar la atención por la posibilidad de errores en el diagnostico histopatológico, por lo tanto, el seguimiento de estos pacientes debe ser más estricta 31 . Un infra diagnóstico (histológico) en la biopsia colposcópica podría no estar detectando una lesión escamosa intraepitelial de alto grado o cáncer cervical invasor 32,33 .…”

Section: Evaluación De La Cito-colposcopia E Histologíaunclassified

Evaluación de la citología, colposcopia e histología para detectar neoplasia cervical intraepitelial de alto grado en el Hospital Materno Infantil German Urquidi

Allende Larrain,

Claure Salinas,

Surriabre Dick

et al. 2024

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Objetivos: Bolivia enfrenta serios problemas en la prevención secundaria del cáncer cervicouterino. Este estudio tiene por objetivo evaluar la eficacia y concordancia de los métodos de diagnóstico en la prevención secundaria del cáncer de cuello uterino para detectar lesiones cervicales intraepiteliales de alto grado. Métodos: Sesenta y dos pacientes con una citología alterada o una prueba VPH-ar positiva complementada obligatoriamente con una citología, fueron sometidas a una colposcopia y biopsia dirigida. Aquellas pacientes con diagnósticos histopatológicos de NIC2+ en la biopsia colposcópica recibieron el tratamiento escisional correspondiente, obteniéndose muestras de tejido para su análisis histopatológico (biopsias escisionales). Los resultados de la citología e impresión colposcópica fueron comparados con los resultados histopatológicos de la biopsia colposcópica. Finalmente, los resultados histopatológicos de NIC2+ de la biopsia colposcópica fueron comparados con los resultados de la biopsia escisional. Resultados: La sensibilidad de la citología y la impresión colposcopia para detectar NIC 2+ fue de 31,43% y 80% respectivamente. La concordancia (Índice Kappa) de los resultados de la citología y la impresión colposcópica comparadas con los resultados NIC 2+ de la biopsia colposcópica fue 0,15 (leve) y 0,43 (moderado) respectivamente. Finalmente, la comparación entre los resultados histopatológicos de la biopsia colposcópica (NIC2+) y de la biopsia escisional dio una coincidencia del 68%. Conclusiones: De las pruebas evaluadas, la citología resulto ser la que tuvo menor eficacia y concordancia para detectar NIC 2+. La colposcopia mejora la identificación de lesiones subyacentes NIC 2+ en pacientes con citologías iguales o menores a LIE-BG.

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Section: Evaluación De La Cito-colposcopia E Histologíaunclassified

Evaluación de la citología, colposcopia e histología para detectar neoplasia cervical intraepitelial de alto grado en el Hospital Materno Infantil German Urquidi

Allende Larrain,

Claure Salinas,

Surriabre Dick

et al. 2024

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“…This was found to be in accordance with various studies like those undertaken by Boicea A, et al, Satyanarayan L et al, Scouza CA et al respectively. [5][6][7]…”

Section: Histopathological Findingsmentioning

confidence: 99%

Colposcopy in evaluation of suspected cervical cancer: a prospective, observational study

Desai

Panchbudhe

2020

Int J Reprod Contracept Obstet Gynecol

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Background: Cervical cancer is the fourth most frequent cancer in women according to World Health Organization. In India the incidence is approximately 1 in 53 compared with 1 in 100 women in more developed regions of the world. Cervical cancer is eminently preventable by early detection using various screening tests like Pap smear, colposcopy, HPV testing. In this study we aim to evaluate the use of colposcopy in early detection of cervical cancer and also assess risk factors for the same. Primary objective was to study the correlation between colposcopic findings and histopathological analysis with a secondary objective to assess risk factors for development of cervical neoplasia.Methods: The study was carried over a period of 2 years (October 2016 to October 2018) with a sample size of 60 in the department of obstetrics and gynecology at tertiary care centre. Participants who fit the inclusion criteria were included in the study after taking a written and informed consent. The colposcopy findings were correlated with the histopathological findings of the cervical biopsy that was undertaken.Results: Colposcopy impression had sensitivity of 93.8% in predicting the histopathology, specificity was 77.3%, positive predictive value was 60%, negative predictive value was 9% and the diagnostic accuracy was 81.7%. On analyzing the risk factors, it was found that the odds of malignant histopathology were 0.55 times decreasing with each unit increase in age (at first intercourse) (p value<0.05).Conclusions: Colposcopy gives immediate and accurate results and its value as a diagnostic test is undisputable. The sensitivity of colposcopy is high and hence in high risk population or remote places where women do not turn for regular screening tests, colposcopy can be used primarily as the screening test.

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Study on the correlation between hTREC and HPV load and cervical CINI/II/III lesions and cervical cancer

Qin

Pan

Chen

et al. 2020

Clinical Laboratory Analysis

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Objective To investigate the correlation between hTREC and human papillomavirus (HPV) load and cervical intraepithelial neoplasia (CIN) grade II/III lesions and cervical cancer. Methods A total of 135 patients with cervical lesions of different degrees admitted to our hospital from January 2016 to February 2017 were selected, including CIN I/III 65 cases, grade III 39 cases, and cervical cancer 31 cases. The expression of hTERC gene was detected by fluorescence in situ hybridization (FISH) in three groups, and the HPV load was detected by second‐generation hybridization capture (HC II) method, and its relationship with cervical lesion grade was analyzed. Department. Results The positive expression rate of hTERC gene amplification was cervical cancer > CIN I/II lesion > CIN III lesion; the positive expression rate of HPV was cervical cancer > CIN I/II lesion > CIN III lesion. After treatment, the positive rate of hTERC gene amplification and HPV expression decreased significantly within 1 year ( P < .05). Spearman's analysis showed that the degree of cervical lesion was positively correlated with hTREC and HPV load ( P < .05). Conclusion hTREC and HPV are closely related to the occurrence and development of cervical precancerous lesions and cervical cancer. The abnormal amplification of hTERC gene increases with the grade of cervical lesions. Both of them can be used as auxiliary indicators for early screening, treatment, and prognosis of cervical cancer.

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Underdiagnosis of cervical intraepithelial neoplasia (CIN) 2 or Worse Lesion in Women with a Previous Colposcopy-Guided Biopsy Showing CIN 1

Cited by 4 publications

References 23 publications

Evaluación de la citología, colposcopia e histología para detectar neoplasia cervical intraepitelial de alto grado en el Hospital Materno Infantil German Urquidi

Evaluación de la citología, colposcopia e histología para detectar neoplasia cervical intraepitelial de alto grado en el Hospital Materno Infantil German Urquidi

Colposcopy in evaluation of suspected cervical cancer: a prospective, observational study

Study on the correlation between hTREC and HPV load and cervical CINI/II/III lesions and cervical cancer

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