Undecylenic Acid in the Treatment of Dermatomycosis

Shapiro, A.; Rothman, Stephen

doi:10.1001/archderm.1945.01510270024004

Cited by 48 publications

(7 citation statements)

References 5 publications

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“…Among the numerous antifungal agents, undecylenic acid (UA) has been known and recognized as a fungicidal substance for decades [ 29 ]. Moreover, one recent study revealed the anti- Candida mechanisms of action of UA, which reduces the hypha-to-yeast ratio and inhibits: hyphal formation, adhesion, mitochondrial activity, cell proliferation, transcriptional regulation of the cell membrane virulent factors, and biofilm formation [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Hexosomes with Undecylenic Acid Efficient against Candida albicans

et al. 2018

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Due to the growing issues with fungal infections, especially with Candida, there is still a need to develop novel anti-Candida materials. One of the known antifungal agents is undecylenic acid (UA), which still cannot be efficiently used due to its oily nature, and thus limited solubility. By taking advantage of the properties of UA, we developed an emulsion with hexagonal phase, i.e., hexosomes, whose structure and morphology was studied by small-angle X-ray scattering and cryo-electron microscopy, respectively. The presence of UA in the hexosome was confirmed by spectroscopy. Moreover, we studied the anti-Candida effect of hexosomes and their cytotoxicity toward human cells. The minimal inhibitory concentration for the 50% and 90% Candida-growth reduction was found at 0.01 and 0.16 wt % hexosomes, respectively (i.e., 2 and 32 pghex/C.a.cell, respectively). The percentage of metabolically active Candida was reduced by 72–96% at hexosome concentrations of 1.0–8.2 pghex/C.a.cell as compared to untreated Candida. Furthermore, at the same concentration range the embedded filamentation test after 24 and 48 h showed the inhibition of both the filamentation and growth of Candida, while the preliminary toxicity test showed that hexosomes were nontoxic for human cells. All these render the here-developed hexosomes with UA efficient and promising anti-Candida agents.

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Section: Introductionmentioning

confidence: 99%

Hexosomes with Undecylenic Acid Efficient against Candida albicans

et al. 2018

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“…The main advantage of this UA-based ointment (commercially known as Desenex) in comparison to other treatments is its nonirritating effect in combination with strong antifungal activity. [6] UA's ineffectiveness in treating tinea capitis and onychomycosis (fungal infections of the scalp and nails), however, provided an opening for the development of new antifungal compounds such as nystatin, griseofulvin, miconazole, and ketoconazole. [7] The currently used antifungal sprays and powders known as Desenex contain miconazole as the active ingredient.…”

Section: Antifungal Activitymentioning

confidence: 99%

Undecylenic Acid: A Valuable and Physiologically Active Renewable Building Block from Castor Oil

2009

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A lot of attention is currently being paid to the transition to a biobased economy. In this movement, most efforts concentrate on the development of bioenergy applications including bioethanol, biodiesel, thermochemical conversion of biomass, and others. However, in the energy sector other nonbiomass alternatives are known, whereas no valuable alternatives are available when thinking about chemical building blocks. Therefore, it is also essential to develop new routes for the synthesis of bio-based chemicals and materials derived thereof. Such intermediates can originate either from plants or from animals. Castor oil is a non-edible oil extracted from the seeds of the castor bean plant Ricinus communis (Euphorbiaceae), which grows in tropical and subtropical areas. Globally, around one million tons of castor seeds are produced every year, the leading producing areas being India, PR China, and Brazil.2 10-Undecenoic acid or undecylenic acid is a fatty acid derived from castor oil that, owing to its bifunctional nature, has many possibilities to develop sustainable applications.

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“…It is an economical antifungal agent and is the active ingredient in many topical over-the-counter antifungal preparations. [25] 10-Undecenoic acid has long been known to be fungicidal against Candida albicans, thus helping achieve a healthy balance of normal vaginal and intestinal flora [26]. It is FDA approved in over the counter medications for skin disorders or problems.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectroscopic, and in Vitro Cytotoxic Studies of Fatty Acid Analogues of 2, 6-Diisopropylphenol

Ali¹,

Faruqi²,

Mustafa³

2010

JCT

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This paper represents the synthesis, spectral analysis and in-vitro cytotoxic studies of some novel fatty acid anti-cancer conjugates of 2, 6-diisopropylphenol (propofol). Propofol is a potent intravenous hypnotic agent which is widely used for the induction and maintenance of anesthesia and for sedation in the intensive care unit. Propofol also possess anti-cancer properties in addition to its sedative effects. Cytotoxicity of all the synthesized compounds was examined against human HeLa cancer cell lines. The anti-cancer screening of these novel drug candidates suggest that all of them reported here may be useful for the treatment of cancer as all of them exhibited significant anticancer activity against human HeLa cancer cell lines. The results indicate that these novel drug candidates might represent a new class of anticancer agents

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Undecylenic Acid in the Treatment of Dermatomycosis

Cited by 48 publications

References 5 publications

Hexosomes with Undecylenic Acid Efficient against Candida albicans

Hexosomes with Undecylenic Acid Efficient against Candida albicans

Undecylenic Acid: A Valuable and Physiologically Active Renewable Building Block from Castor Oil

Synthesis, Spectroscopic, and in Vitro Cytotoxic Studies of Fatty Acid Analogues of 2, 6-Diisopropylphenol

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