Uncovering the molecular landscape of meningiomas and the impact of perioperative steroids on patient survival

Furtak, Jacek; Birski, Marcin; Bebyn, Marek; Śledzińska, Paulina; Krajewski, Stanisław; Szylberg, Tadeusz; Krystkiewicz, Kamil; Przybył, Jakub; Zielińska, Karolina; Soszyńska, Krystyna; Majdańska, Anna; Ryfa, Agata; Bogusiewicz, Joanna; Bojko, Barbara; Harat, Marek

doi:10.1007/s00701-023-05567-w

Cited by 2 publications

(2 citation statements)

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“…CNS invasion has been associated with AKT1 mutations as well as alterations of metalloproteases and adhesion molecule expression ( Jalali et al, 2015 ; Barresi et al, 2021 ; Qin et al, 2021 ). The pathophysiology of CNS invasion seems to undergo different stages ( Quintero-Fabian et al, 2019 ; Maggio et al, 2021 ; Furtak et al, 2023 ; Go and Kim, 2023 ). The crucial point for the initiation of meningioma cells invasion is the cleavage of the basement membrane and the following remodeling of the extracellular matrix (ECM) by specific matrix metalloproteinases ( MMPs ) ( Quintero-Fabian et al, 2019 ; Maggio et al, 2021 ; Furtak et al, 2023 ; Go and Kim, 2023 ).…”

Section: Pathophysiology and Molecular Profile Of Cns Invasionmentioning

confidence: 99%

“…The pathophysiology of CNS invasion seems to undergo different stages ( Quintero-Fabian et al, 2019 ; Maggio et al, 2021 ; Furtak et al, 2023 ; Go and Kim, 2023 ). The crucial point for the initiation of meningioma cells invasion is the cleavage of the basement membrane and the following remodeling of the extracellular matrix (ECM) by specific matrix metalloproteinases ( MMPs ) ( Quintero-Fabian et al, 2019 ; Maggio et al, 2021 ; Furtak et al, 2023 ; Go and Kim, 2023 ). Several activators of MMPs , like uPA have been linked to plasmin mediated matrix breakdown and cell adhesion ( Fleetwood et al, 2014 ).…”

Section: Pathophysiology and Molecular Profile Of Cns Invasionmentioning

confidence: 99%

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Meningiomas with CNS invasion

2023

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CNS invasion has been included as an independent criterion for the diagnosis of a high-grade (WHO and CNS grade 2 and 3) meningioma in the 2016 and more recently in the 2021 WHO classification. However, the prognostic role of brain invasion has recently been questioned. Also, surgical treatment for brain invasive meningiomas may pose specific challenges. We conducted a systematic review of the 2016–2022 literature on brain invasive meningiomas in Pubmed, Scopus, Web of Science and the Cochrane Library. The prognostic relevance of brain invasion as a stand-alone criterion is still unclear. Additional and larger studies using robust definitions of histological brain invasion and addressing the issue of sampling errors are clearly warranted. Although the necessity of molecular profiling in meningioma grading, prognostication and decision making in the future is obvious, specific markers for brain invasion are lacking for the time being. Advanced neuroimaging may predict CNS invasion preoperatively. The extent of resection (e.g., the Simpson grading) is an important predictor of tumor recurrence especially in higher grade meningiomas, but also – although likely to a lesser degree – in benign tumors, and therefore also in brain invasive meningiomas with and without other histological features of atypia or malignancy. Hence, surgery for brain invasive meningiomas should follow the principles of maximal but safe resections. There are some data to suggest that safety and functional outcomes in such cases may benefit from the armamentarium of surgical adjuncts commonly used for surgery of eloquent gliomas such as intraoperative monitoring, awake craniotomy, DTI tractography and further advanced intraoperative brain tumor visualization.

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Section: Pathophysiology and Molecular Profile Of Cns Invasionmentioning

confidence: 99%

Section: Pathophysiology and Molecular Profile Of Cns Invasionmentioning

confidence: 99%

Meningiomas with CNS invasion

2023

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Secretory Meningioma of the Right Frontal Lobe: Clinical Presentation and Pathological Insights

Markov,

Bechev,

Aleksiev

et al. 2024

Cureus

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This article presents a case study of a rare convexity meningioma located in the frontal lobe of the right cerebellar hemisphere. Meningiomas comprise a substantial part of central nervous system neoplasms and are classified into benign, atypical, or anaplastic categories, each encompassing a variety of histological subtypes, among which the secretory meningioma is notably rare.A 77-year-old male presented with a clinical history of headache, impaired memory functions, an initial form of apathetic-abulic syndrome, and a single seizure, which were considered to be indicative of epileptic symptoms that had been present for several weeks. The imaging studies conducted showed a convexity tumor characterized by a rounded morphology and homogeneous contrast enhancement, positioned adjacent to the frontal lobe's cortical surface. This clinical report details the pathology of a secretory type of meningioma, which is distinguished by the atypical epithelial differentiation of meningothelial cells, resulting in hyaline fiber production. The neoplasm's anatomical accessibility permitted successful surgical resection. The tumor's position was appropriate for surgical removal, and the histological variant, along with the patient's favorable clinical course, is of particular scientific interest.

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Uncovering the molecular landscape of meningiomas and the impact of perioperative steroids on patient survival

Cited by 2 publications

References 29 publications

Meningiomas with CNS invasion

Meningiomas with CNS invasion

Secretory Meningioma of the Right Frontal Lobe: Clinical Presentation and Pathological Insights

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