Unconventional Device and Material Approaches for Monolithic Biointegration of Implantable Sensors and Wearable Electronics

Koo, Ja Hoon; Song, Jae Yoon; Yoo, Sun-Ho; Sunwoo, Sung‐Hyuk; Son, Donghee; Kim, Dae‐Hyeong

doi:10.1002/admt.202000407

Cited by 41 publications

(37 citation statements)

References 184 publications

(158 reference statements)

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“…Due to progress in materials research, innovations in deformable structures, advancement in electronics, and related engineering technologies, wearable electronics are being propelled as one of the most active research areas. [1][2][3][4][5][6][7][8][9][10][11][12] Thus, there is an increase in both academia and industry in the importance of development of next-generation wearable technologies involving a variety of forms such as smart clothes, watches, bands, patches, bracelets, eyeglass, and electronic skin, etc. [1] Wearable sensors, the heart of wearable electronics technology, are usually interfaced with the human body either by laminating onto the surface of the skin or embedding in a body-worn textile and different constitutes and concentrations of volatile organic compounds (VOCs) depending upon the disease state.…”

Section: Introductionmentioning

confidence: 99%

“…without modifying the sensor architecture or device chemistry. [78][79][80] Recently, several overviews have been reported on flexible and wearable sensors, [5][6][7][8][9][10][11][12][13]70,[81][82][83][84][85][86][87][88][89] though no comprehensive review has mainly focused on recent developments on wearable gas sensors for potential application in environmental monitoring, healthcare, public safety, and food quality monitoring. We systematically discussed the various components of gas sensors and their requirements for wearable applications as illustrated in Scheme 1.…”

Section: Introductionmentioning

confidence: 99%

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Recent Advancements in Development of Wearable Gas Sensors

Bag

Lee

2021

Adv Materials Technologies

127

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In the era of the Internet of Things, wearable technologies are expected to become an indispensable part of daily life. In recent times, highly sensitive, flexible, and stretchable electronic gas sensors are gaining tremendous interest due to their applicability in wearable electronics applications. The construction of wearable gas sensors are reviewed for real‐time, highly sensitive, and selective detection of hazardous gases at room temperature (RT) that can be laminated onto a human body or integrated with body‐worn textile or other consumer products, utilizing carbon nanomaterials, conductive polymers, 2D nanostructured materials, and their composites. Sensing materials, transduction techniques, and substrates for high‐performance wearable gas sensing are discussed in detail. The critical challenges for future development of wearable gas sensors are presented. Wearable gas sensors are believed to have great potential in environmental monitoring, healthcare, public safety, security, as well as food quality monitoring.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent Advancements in Development of Wearable Gas Sensors

Bag

Lee

2021

Adv Materials Technologies

127

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“…Implants can provide real-time continuous health monitoring and precision treatments in human bodies in convenient ways. [1][2][3][4] Thus, active research has been conducted to develop efficient wireless implantable medical electronic devices to improve the patient's quality of life. Diverse functions and designs of implants have been developed.…”

Section: Introductionmentioning

confidence: 99%

Wireless Electrical Power Delivery Using Light through Soft Skin Tissues under Misalignment and Deformation

Seo

Kim

Jeong

et al. 2022

Adv Materials Inter

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Among these, wireless power transfer via RF inductive coupling has the advantage of providing relatively high power. [31,32] However, RF wireless power transfer may have limited efficiency when the transceiver is miniaturized [16,33,34] or misaligned. [28,31] The technology using photovoltaics can also provide adequate electrical power to implants by capturing ambient light [24,36] or capturing light from an external light source. [37,38] While these technological advancements are encouraging, the characteristics of electrical performance when using devices under deformation or misalignment caused by opaque soft skin tissues have not yet been reported. The electrical performance characteristics are essentials in integrating reliable power systems to various electronic implants Herein, we report the electrical performance characteristics of a PV implant and external light source patch depending on misalignment, implantation depth, and deformation, which may occur in practical applications. Our experimental studies included ex vivo trials with a PV implant under an animal skin whose surface was covered by an attachable light source patch. We varied the lateral misalignment distance, implantation depth, and bending radius and direction. These results should be useful in the design and application of wireless power transfer using light for implantable medical electronic devices.

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“…They include biosensors, bioconductors, electrostimulated drug delivery systems, and tissue engineering for the diagnosis and treatment of chronic diseases [ 1 ]. IEs can transmit and receive bioelectronic signals from the brain, heart, or muscle, for monitoring and curing chronic diseases [ 2 , 3 , 4 , 5 ]. However, it is challenging to overcome the drawbacks of the hard and rigid characteristics of conventional IEs [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Self-Healing, Stretchable, Biocompatible, and Conductive Alginate Hydrogels through Dynamic Covalent Bonds for Implantable Electronics

et al. 2021

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Implantable electronics have recently been attracting attention because of the promising advances in personalized healthcare. They can be used to diagnose and treat chronic diseases by monitoring and applying bioelectrical signals to various organs. However, there are challenges regarding the rigidity and hardness of typical electronic devices that can trigger inflammatory reactions in tissues. In an effort to improve the physicochemical properties of conventional implantable electronics, soft hydrogel-based platforms have emerged as components of implantable electronics. It is important that they meet functional criteria, such as stretchability, biocompatibility, and self-healing. Herein, plant-inspired conductive alginate hydrogels composed of “boronic acid modified alginate” and “oligomerized epigallocatechin gallate,” which are extracted from plant compounds, are proposed. The conductive hydrogels show great stretchability up to 500% and self-healing properties because of the boronic acid-cis-diol dynamic covalent bonds. In addition, as a simple strategy to increase the electrical conductivity of the hydrogels, ionically crosslinked shells with cations (e.g., sodium) were generated on the hydrogel under physiological salt conditions. This decreased the resistance of the conductive hydrogel down to 900 ohm without trading off the original properties of stretchability and self-healing. The hydrogels were used for “electrophysiological bridging” to transfer electromyographic signals in an ex vivo muscle defect model, showing a great bridging effect comparable to that of a muscle-to-muscle contact model. The use of plant-inspired ionically conductive hydrogels is a promising strategy for designing implantable and self-healable bioelectronics.

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Unconventional Device and Material Approaches for Monolithic Biointegration of Implantable Sensors and Wearable Electronics

Cited by 41 publications

References 184 publications

Recent Advancements in Development of Wearable Gas Sensors

Recent Advancements in Development of Wearable Gas Sensors

Wireless Electrical Power Delivery Using Light through Soft Skin Tissues under Misalignment and Deformation

Self-Healing, Stretchable, Biocompatible, and Conductive Alginate Hydrogels through Dynamic Covalent Bonds for Implantable Electronics

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