Uncommon presentation of mycosis fungoides: Eyelid margin involvement

Abstract

Mycosis fungoides is a cutaneous T-cell lymphoma that has been rarely reported to involve ocular structures. A 33-year-old woman who had received therapy for mycosis fungoides on the trunk for 11 years, presented to our clinic with new plaques and tumors on her eyebrows and eyelid margin, and alopecia of her eyelashes and eyebrow. The histopathological examinations supported the diagnosis of mycosis fungoides. There was no intraocular involvement with tumor. The mycosis fungoides was of stage II B, and the patient was referred to medical oncology and radiation oncology clinics for treatment. She was placed on a radiotherapy schedule. The involvement of mycosis fungoides in the ocular area is rare in the published work. The importance of eye involvement is being seen in advanced cases, and there is a possible association between mycosis fungoides and poor prognosis by being an indicator of systemic involvement.

Alterações oculares em micose fungóide associada com vírus linfotrópico de células t humanas tipo I

“…Também foram encontrados ectrópio cicatricial, meibomite, calázio e madarose (7) . Já Goldberg et al descreveram um caso de ulceração de córnea em paciente com lesão palpebral (6) , enquanto Gul et al descreveram madarose e tumores em bordas palpebrais e sobrancelhas (8) . Nos casos aqui descritos, foram evidenciados, no caso 1, ceratopatia ponteada e ceratoconjuntivite seca e, no caso 2, a paciente apresentava ceratoconjuntivite seca, nódulos difusos em bordas palpebrais e espessamento em pálpebras.…”

Alterações oculares em micose fungóide associada com vírus linfotrópico de células t humanas tipo I

“…Também foram encontrados ectrópio cicatricial, meibomite, calázio e madarose (7) . Já Goldberg et al descreveram um caso de ulceração de córnea em paciente com lesão palpebral (6) , enquanto Gul et al descreveram madarose e tumores em bordas palpebrais e sobrancelhas (8) . Nos casos aqui descritos, foram evidenciados, no caso 1, ceratopatia ponteada e ceratoconjuntivite seca e, no caso 2, a paciente apresentava ceratoconjuntivite seca, nódulos difusos em bordas palpebrais e espessamento em pálpebras.…”

Alopecia in Lymphomas

“…The histopathological examinations supported the diagnosis of mycosis fungoides. There was no intraocular involvement with tumor [4].…”

Eyelid involvement of primary cutaneous lymphomas: A clinical perspective

“…Based on the observations in a few cases, it has been proposed that there is a possible relationship between eyelid MF and systemic involvement that indicates a poor prognosis. 26,27 Similarly, it has been stated that CTCLs of the eyelid seem generally to have a good prognosis with the exception of MF and NK-T-cell lymphoma. 3 On the contrary, in a multicentre study of eye cancer centres, MF patients with eyelid involvement had a relatively good prognosis with a 5-year disease-specific survival of 86% compared to other lymphomas.…”

“…The prognostic significance of eyelid involvement in MF is a matter of debate. Based on the observations in a few cases, it has been proposed that there is a possible relationship between eyelid MF and systemic involvement that indicates a poor prognosis 26,27 . Similarly, it has been stated that CTCLs of the eyelid seem generally to have a good prognosis with the exception of MF and NK‐T‐cell lymphoma 3 .…”

Alterações oculares em micose fungóide associada com vírus linfotrópico de células t humanas tipo I

“…Também foram encontrados ectrópio cicatricial, meibomite, calázio e madarose (7) . Já Goldberg et al descreveram um caso de ulceração de córnea em paciente com lesão palpebral (6) , enquanto Gul et al descreveram madarose e tumores em bordas palpebrais e sobrancelhas (8) . Nos casos aqui descritos, foram evidenciados, no caso 1, ceratopatia ponteada e ceratoconjuntivite seca e, no caso 2, a paciente apresentava ceratoconjuntivite seca, nódulos difusos em bordas palpebrais e espessamento em pálpebras.…”

Alopecia in Lymphomas

“…The histopathological examinations supported the diagnosis of mycosis fungoides. There was no intraocular involvement with tumor [4].…”

Eyelid involvement of primary cutaneous lymphomas: A clinical perspective

“…Based on the observations in a few cases, it has been proposed that there is a possible relationship between eyelid MF and systemic involvement that indicates a poor prognosis. 26,27 Similarly, it has been stated that CTCLs of the eyelid seem generally to have a good prognosis with the exception of MF and NK-T-cell lymphoma. 3 On the contrary, in a multicentre study of eye cancer centres, MF patients with eyelid involvement had a relatively good prognosis with a 5-year disease-specific survival of 86% compared to other lymphomas.…”

“…The prognostic significance of eyelid involvement in MF is a matter of debate. Based on the observations in a few cases, it has been proposed that there is a possible relationship between eyelid MF and systemic involvement that indicates a poor prognosis 26,27 . Similarly, it has been stated that CTCLs of the eyelid seem generally to have a good prognosis with the exception of MF and NK‐T‐cell lymphoma 3 .…”

Alterações oculares em micose fungóide associada com vírus linfotrópico de células t humanas tipo I

“…Também foram encontrados ectrópio cicatricial, meibomite, calázio e madarose (7) . Já Goldberg et al descreveram um caso de ulceração de córnea em paciente com lesão palpebral (6) , enquanto Gul et al descreveram madarose e tumores em bordas palpebrais e sobrancelhas (8) . Nos casos aqui descritos, foram evidenciados, no caso 1, ceratopatia ponteada e ceratoconjuntivite seca e, no caso 2, a paciente apresentava ceratoconjuntivite seca, nódulos difusos em bordas palpebrais e espessamento em pálpebras.…”

Alopecia in Lymphomas

“…The histopathological examinations supported the diagnosis of mycosis fungoides. There was no intraocular involvement with tumor [4].…”

Eyelid involvement of primary cutaneous lymphomas: A clinical perspective

“…Based on the observations in a few cases, it has been proposed that there is a possible relationship between eyelid MF and systemic involvement that indicates a poor prognosis. 26,27 Similarly, it has been stated that CTCLs of the eyelid seem generally to have a good prognosis with the exception of MF and NK-T-cell lymphoma. 3 On the contrary, in a multicentre study of eye cancer centres, MF patients with eyelid involvement had a relatively good prognosis with a 5-year disease-specific survival of 86% compared to other lymphomas.…”

“…The prognostic significance of eyelid involvement in MF is a matter of debate. Based on the observations in a few cases, it has been proposed that there is a possible relationship between eyelid MF and systemic involvement that indicates a poor prognosis 26,27 . Similarly, it has been stated that CTCLs of the eyelid seem generally to have a good prognosis with the exception of MF and NK‐T‐cell lymphoma 3 .…”