Uncommon borderline ovarian tumours: A clinicopathologic study of seventeen patients

Abstract

Objective:To evaluate uncommon types of borderline ovarian tumors (BOT) and define the clinical, surgical, and pathologic features.Material and Methods:Seventeen patients who were treated in our hospital between 1990 and 2017 were identified. Patients’ data were collected from the gynecologic oncology clinic electronic database, patients’ files, and pathology reports. Conservative surgery was defined as preservation of the uterus and at least part of one ovary.Results:The mean age was 47 (range, 22-70) years. Based on histopathologic tumor type, there was mixed tumor in five (29.4%) patients, endometrioid-type in nine (52.9%), seromusinous-type in two (11.8%), and Brenner-type in one (5.9%). Conservative surgery was performed in 4 patients. Two patients with endometrioid BOT had synchronous endometrial pathology, including one (11%) patient with endometrial cancer, one (11%) with endometrial hyperplasia without atypia, and 3 (33%) patients had endometriosis. The median follow-up was 19 (range, 1-137) months. No recurrence was observed during the follow-up period.Conclusion:In our small volume case series, it could be said that non-serous/non-mucinous BOT has excellent prognosis. However, endometrial pathology should be checked in endometrioid type.

<p>Ultraconservative, Fertility Sparing Treatment of Bilateral Borderline Ovarian Tumors: A Case Report of a 26-Year-Old, 0-Gravida with an Endometrioid Borderline Ovarian Tumor of the Right Ovary and a Sero-Mucinous Borderline Ovarian Tumor of the Left Ovary and a Review of the Literature</p>

“…Uzan et al mentioned 1 case, 25 Snyder et al 1 case, 26 Bell and Kurman et al 3 cases, 28 Jia et al 5 cases 1 and Yüksel et al 1 case. 23 Thus, bilateral eBOTs comprise approximately 3-9% of all eBOT-cases. 23 BOTs in general have an excellent prognosis, allowing for the consideration of conservative surgery.…”

“…23 Thus, bilateral eBOTs comprise approximately 3-9% of all eBOT-cases. 23 BOTs in general have an excellent prognosis, allowing for the consideration of conservative surgery. This has changed the gold standard from a radical procedure comprising BSOP to a fertility sparing management, especially in young patients.…”

“…Nr. 1,21,23,25,27,28,29). Two additional articles on eBOTs were selected due to their frequent citation in several of the eBOT papers (Ref.…”

“…20 Among BOTs, endometrioid borderline ovarian tumors (eBOTs) constitute a rare group, comprising up to only 0.2% of all epithelial ovarian tumors 21,22 and 2-10% of BOTs. 1,23,24 Very little data is available on the prognosis and therefore recommendations concerning the surgical management with respect to fertility in specific. 1,[25][26][27] Even less information exists on bilateral eBOTs.…”

“…In the literature, there have only been reports on 11 cases so far. 1,23 Thus, due to the rare occurrence of eBOTs and bilateral BOTs including an eBOT, and the lack of data on the natural history as well as on the safety of conservative surgical management, especially in young patients wishing to preserve their fertility, we present in the following the case of a 26-year-old Asian woman with bilateral BOTs, an eBOT on the right ovary and a sero-mucinous BOT on the left ovary, and provide a review of the literature on eBOTs.…”