With the rapid development of China's economic level and the continuous improvement of energy consumption level, China's attention to energy production and energy has gradually increased. This paper aims to study the application of MES systems based on industrial ecology in energy measurement management. From the direction of ecology of sustainable development theory and the theory of industrial ecology, this paper proposes the enterprise ecosystem model not only for the specific enterprise unit, but also from the perspective of industrial system. This paper systematically studies the efficient energy management of enterprises, through the construction technology of MES platform and various coding scheMES, designs a set of energy management system based on MES, and applies the system to the enterprise energy measurement. This paper adopts the basic design concept of three-layer architecture in the overall design process, which divides the whole system into different functional units and sub-class functions, and finally ensures the correct use and good operation of the system. The experiment has proved that the work efficiency of this system has been improved to 100%. Compared with the traditional energy metering management system, the data processing speed of this paper is increased by about 5 tiMES.