2016
DOI: 10.18632/aging.100971
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: Senescent cells secrete senescence-associated secretory phenotype (SASP) proteins to carry out several functions, such as sensitizing surrounding cells to senesce; immunomodulation; impairing or fostering cancer growth; and promoting tissue development. Identifying secreted factors that achieve such tasks is a challenging issue since the profile of secreted proteins depends on genotoxic stress and cell type. Currently, researchers are trying to identify common markers for SASP. The present investigation compar… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

5
139
0
1

Year Published

2017
2017
2019
2019

Publication Types

Select...
4
1

Relationship

0
5

Authors

Journals

citations
Cited by 164 publications
(43 citation statements)
references
References 42 publications
(43 reference statements)
5
139
0
1
Order By: Relevance
“…44 More recently, using LC-MS/MS analysis of SASP and an Ingenuity Pathway Analysis of secretomes, Ozcan and colleagues identified PAI-1-IGFBP3 is one of the three key signaling pathways involved in the stressor-induced replicative senescence of mesenchymal stromal cells. 45 Taken together, these consistent findings from disparate laboratories and experimental systems, speak to the pivotal role of PAI-1 in induction of cellular senescence through regulation of different downstream SASPs. Our recent work further illustrates the causative role of PAI-1 in cellular senescence (Figure 3).…”
Section: Pai-1 Is a Key Mediator Of Cellular Senescencementioning
confidence: 70%
“…44 More recently, using LC-MS/MS analysis of SASP and an Ingenuity Pathway Analysis of secretomes, Ozcan and colleagues identified PAI-1-IGFBP3 is one of the three key signaling pathways involved in the stressor-induced replicative senescence of mesenchymal stromal cells. 45 Taken together, these consistent findings from disparate laboratories and experimental systems, speak to the pivotal role of PAI-1 in induction of cellular senescence through regulation of different downstream SASPs. Our recent work further illustrates the causative role of PAI-1 in cellular senescence (Figure 3).…”
Section: Pai-1 Is a Key Mediator Of Cellular Senescencementioning
confidence: 70%
“…Acquiring functional EVs by target cells is the basic step required for EV therapy, and the whole secretome of MSCs is modified by senescence [26]. The contents of EVs may differ depending on the passage of its original cells.…”
Section: Discussionmentioning
confidence: 99%
“…The increase in secretion of MMP1, MMP3 and MMP9 and absence of their inhibitors TIMPs might directly trigger ECM degradation [41][42][43]45]. In hADSCs SMS, the presence of mitogenic growth factors such as transforming growth factors (TGF β1 and β2), basic Fibroblast Growth Factor (FGF-6), Hepatocyte Growth Factor (HGF), Vascular Endothelial Growth Factor (VEGF), Insulinlike Growth Factor -1 (IGF-1), and Platelet-derived Growth Factors (PDGF) as well as number of cytokines (shown in Figure 3) suggests that the senescence-triggered cellular communication could result in an increase in fibroblasts, keratinocytes, epithelial and endothelial cell division, migration or differentiation, thus triggering ECM remodeling [46][47][48][49][50].…”
Section: Discussionmentioning
confidence: 99%