Ultraviolet Radiation of Melanocytic Nevi

Hofmann-Wellenhof, R; Soyer, H. Peter; Wolf, IH; Smolle, Josef; Reischle, Sebastian; Rieger, E.; Kenet, Robert O.; Wolf, Peter; Kerl, Helmut

doi:10.1001/archderm.134.7.845

Cited by 56 publications

(54 citation statements)

References 32 publications

(28 reference statements)

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“…Hofmann’s and Tronnier’s groups studied the clinical and dermoscopic effects of UVB on nevi in patients treated with artificial UVR suffering from psoriasis and other skin diseases [33] and on intentional 2-MED UVB-irradiated half-nevi [34, 38], similar to our current design. They observed significant modifications in these irradiated lesions compared to nonirradiated nevi.…”

Section: Discussionmentioning

confidence: 99%

Development of a Human in vivo Method to Study the Effect of Ultraviolet Radiation and Sunscreens in Melanocytic Nevi

et al. 2008

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Background: Ultraviolet radiation (UVR) plays an important role in the development of melanocytic lesions. Sunscreens have shown an impact in the prevention of UVR damage; however, their role in melanocytes has not been well established. The aim was to design and validate an in vivo human model to study the influence of UVR and sunscreen protection on nevi. Methods: A model describing clinical, dermoscopic, histopathological and molecular changes after UVR with or without protection was elaborated. Two UVB minimal erythema doses were irradiated on 4 nonsuspicious nevi from 4 patients; previously one half of each lesion was protected, in 2 cases with a physical opaque material and in the other 2 lesions by applying a high physical and chemical protection sunscreen (containing octocrylene, Parsol 1789, titanium dioxide, Mexoryl SX™, Mexoryl XL™). Lesions were excised 7 days afterwards. Results: After 7 days, clinical and dermoscopic changes (more pigmentation, erythema, dotted vessels, blurred network) were noted comparing the lesions before and after irradiation, especially when comparing both sides of each nevus (protected and nonprotected). Histopathological and immunohistochemical studies demonstrated marked melanocytic activation on nonprotected areas and a high proliferation index of keratinocytes. Both physical and sunscreen protections seem to avoid these changes. Conclusion: A useful and secure human model to study the UVR influence, and efficacy of sunscreens, on melanocytic lesions was developed. In vivo and ex vivo differences between irradiated nevus versus irradiated nevus plus sunscreen or physical protection were found.

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Section: Discussionmentioning

confidence: 99%

Development of a Human in vivo Method to Study the Effect of Ultraviolet Radiation and Sunscreens in Melanocytic Nevi

et al. 2008

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“…The sunshade theory of black nevi might be further supported by previous observations regarding UV-dependent dermoscopic changes in melanocytic nevi. [19][20][21][22] The UV-induced changes constitute a significant darkening of color, increased fading of borders, increase or decrease of a prominent pigment network, reduction of hypopigmentation, and development of new black dots or blotches. At electron microscopy, the black dots or blotches correspond to melanosomes in keratinocytes, and at histopathologic analysis to pigmented parakeratosis (ie, transepidermal pigment transfer and elimination), which can be explained by UV-induced increased melanin synthesis of melanocytes, resulting in a subsequent increased pigment transfer between melanocytes and keratinocytes (melanocyte-keratinocyte unit).…”

Section: Commentmentioning

confidence: 99%

“…At electron microscopy, the black dots or blotches correspond to melanosomes in keratinocytes, and at histopathologic analysis to pigmented parakeratosis (ie, transepidermal pigment transfer and elimination), which can be explained by UV-induced increased melanin synthesis of melanocytes, resulting in a subsequent increased pigment transfer between melanocytes and keratinocytes (melanocyte-keratinocyte unit). 19 However, because irregular black dots and blotches may also be associated with melanoma, 6 it is generally recommended that nevi not be examined after intense UV exposure to avoid unnecessary excision of benign nevi. Because we included only individuals without sun exposure before the examination, it seems remarkable that the predominant nevus type in dark-skinned individuals exhibits the same basic dermoscopic patterns as UVirradiated nevi, such as dark brown color, prominent pigment network, and the central black blotch.…”

Section: Commentmentioning

confidence: 99%

Nevus Type in Dermoscopy Is Related to Skin Type in White Persons

Zalaudek¹,

Argenziano²,

Mordente³

et al. 2007

Arch Dermatol

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“…One of the major environmental risk factors for moles is solar ultraviolet radiation (Hofmann-Wellenhof et al, 1998;Husain et al, 1991;Longstreth, 1988). Nevus counts in young children are strongly related to episodes of sunburn, cumulative sun exposure, and markers of sun sensitivity, such as fair complexion and tendency to burn (Harrison et al, 1994;Luther et al, 1996).…”

mentioning

confidence: 99%