Ultraviolet photodissociation spectroscopy of cold, isolated adenine complexes with a potassium cation

Baek, Ji Young; Choi, Chang Min; Eun, Han Jun; Park, Kwang Sik; Choi, Myung Chul; Heo, Jiyoung; Kim, Nam Joon

doi:10.1016/j.cplett.2015.06.045

Cited by 6 publications

(3 citation statements)

References 39 publications

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“…Also UVPD and IRMPD spectroscopy of alkali-metal cation–adenine complexes and their hydrated forms confirm that N3 binding is preferred in a bidentate fashion with the N9 position on the tautomer A7 and supports the view that N3 attack has likely been unduly undervalued.…”

Section: Discussionsupporting

confidence: 52%

“…Interestingly, although it is commonly held that the N3 site of adenine is not favored for electrophilic attack on adenine 11 , there is ample recent evidence made by IRMPD action spectroscopy showing that the N3 position is in fact favored in the protonation and alkali metal cation attachment of both the free base and adenine 9 DNA and RNA nucleosides [59][60][61] and nucleotides. 39 Also UVPD 62 and IRMPD 63 spectroscopy of alkali metal cation-adenine complexes and their hydrated forms confirm that N3 binding is preferred in a bidentate fashion with the N9 position on the tautomer A7 and support the view that N3 attack has likely been unduly undervalued.…”

Section: Resultsmentioning

confidence: 80%

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Undervalued N3 Coordination Revealed in the Cisplatin Complex with 2′-Deoxyadenosine-5′-monophosphate by a Combined IRMPD and Theoretical Study

et al. 2017

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The complex obtained by the reaction of cisplatin and 2'-deoxyadenosine-5'-monophosphate (5'-dAMP) in water has been isolated and detected by electrospray ionization mass spectrometry. The so-formed cis-[PtCl(NH)(5'-dAMP)] complex has been studied in detail by infrared multiple photon dissociation (IRMPD) spectroscopy in two spectral ranges, namely, 700-1900 and 2800-3800 cm, backed by quantum-chemical calculations at the B3LYP/LACV3P/6-311G** level of theory. In agreement with the computational results, the vibrational spectroscopic characterization of cis-[PtCl(NH)(5'-dAMP)] shows that the sampled ionic population comprises two major isomers, differentiated in the X-H stretching region by their distinct fragmentation patterns. One of these species presents coordination of the platinum moiety at the N3 position of adenine, whereas in the second one, platinum is bound at the N1 position of adenine. IRMPD kinetics have allowed an estimation of their relative proportions. Surprisingly, the most abundant component of cis-[PtCl(NH)(5'-dAMP)] is the N3 isomer, although it is slightly less stable than the other potential isomers in the gas phase. In contrast, the lowest-energy species, namely, the one showing cisplatin binding to the N7 position of adenine, seems to be the one less represented in the sampled ionic population. These findings suggest that the reaction of cisplatin with 5'-dAMP is governed by the kinetics of the process occurring in solution rather than by the thermodynamic factors.

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Section: Discussionsupporting

confidence: 52%

Section: Resultsmentioning

confidence: 80%

Undervalued N3 Coordination Revealed in the Cisplatin Complex with 2′-Deoxyadenosine-5′-monophosphate by a Combined IRMPD and Theoretical Study

et al. 2017

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“…"Desenvolvimento e validação da espectroscopia vibracional de íons em fase gasosa" [91][92][93]94 . 110 Uma das formas experimentais de medir parâmetros físicos em espécies químicas é pela espectroscopia, campo que estuda a interação de átomos, moléculas e íons com radiações eletromagnéticas.…”

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Desenvolvimento e validação da espectroscopia vibracional de íons em fase gasosa

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Selective Probing of Potassium Ion in Solution by Intramolecular Excimer Fluorescence of Dibenzo‐Crown Ethers

et al. 2018

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Observation of an excimer fluorescence in solution is proposed for detecting the encapsulation of potassium ion as opposed to other alkali ions by dibenzo-crown ethers. The scheme has been validated by ultraviolet photodissociation (UVPD) spectroscopy of dibenzo-21-crown-7 and dibenzo-24-crown-8 complexes with potassium ion, K ⋅ DB21C7 and K ⋅ DB24C8, performed under cold (∼10 K) conditions in the gas phase and by quantum chemical calculations of the geometry and electronic structures of the complexes. Calculations suggest the formation of a closely spaced excimer structure of benzene rings only for the K ⋅ DB24C8. Interaction of the rings may lead to lifetime broadening in UV absorption, which is experimentally observed in the gas phase, indeed, only for this cold complex. Consistently, intramolecular excimer fluorescence of DB24C8 in solution is observed only for K ⋅ DB24C8. The excimer fluorescence is not observed with other alkali metal ions. The detection of such intramolecular excimer fluorescence can, therefore, potentially serve as a simple, background-free, selective probe of potassium ion in solution.

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Ultraviolet photodissociation spectroscopy of cold, isolated adenine complexes with a potassium cation

Cited by 6 publications

References 39 publications

Undervalued N3 Coordination Revealed in the Cisplatin Complex with 2′-Deoxyadenosine-5′-monophosphate by a Combined IRMPD and Theoretical Study

Undervalued N3 Coordination Revealed in the Cisplatin Complex with 2′-Deoxyadenosine-5′-monophosphate by a Combined IRMPD and Theoretical Study

Desenvolvimento e validação da espectroscopia vibracional de íons em fase gasosa

Selective Probing of Potassium Ion in Solution by Intramolecular Excimer Fluorescence of Dibenzo‐Crown Ethers

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