volume 10, issue 2, P212-228 2018
DOI: 10.18632/aging.101383
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Yuxin Yi, Hongfu Xie, Xiao Xiao, Ben Wang, Rui Du, Yingzi Liu, Zibo Li, Jun Wang, Lunquan Sun, Zhili Deng, Ji Li

Abstract: In this study, we report the role of DNA methyltransferase 1 (DNMT1) in ultraviolet A (UVA)-induced senescence in human dermal fibroblasts (HDFs). We show that DNMT1 expression was significantly reduced during UVA-induced senescence, and this senescence could be alleviated or aggravated by the up- or down-regulation of DNMT1, respectively. Expression of the transcription factor zinc finger E-box binding homeobox 1(ZEB1) also decreased after UVA irradiation, following a UVA-induced increase of intracellular rea…

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