1982
DOI: 10.1001/archderm.118.9.679
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Ultrastructural studies of necrolytic migratory erythema

Abstract: Necrolytic migratory erythema is a disorder highly suggestive of glucagonoma syndrome. We carried out histologic and electron microscopic studies of the skin lesions in a 57-year-old woman with the glucagonoma syndrome. Light microscopic studies revealed hyperkeratosis, parakeratosis, formation of clefts in the upper epidermis, and scattered dyskeratotic cells. Ultrastructurally, the intercellular spaces were widened in the upper epidermis and desmosomes were reduced in number. The cytoplasm of affected cells … Show more

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Cited by 7 publications
(6 citation statements)
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“…Our ultrastructural findings, which are consistent with previous reports [6,7], suggest that the degenera tive changes originate in the mid or upper epidermal layers, as kératinocytes in the lower layers are normal or show only regenerative hyperproliferation. Typical of NME are widened intercellular spaces, vacuoliza tion, cytolysis, dyskeratosis and parakeratosis, and a rather clear-cut demarcation between necrobiotic and normal layers.…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…Our ultrastructural findings, which are consistent with previous reports [6,7], suggest that the degenera tive changes originate in the mid or upper epidermal layers, as kératinocytes in the lower layers are normal or show only regenerative hyperproliferation. Typical of NME are widened intercellular spaces, vacuoliza tion, cytolysis, dyskeratosis and parakeratosis, and a rather clear-cut demarcation between necrobiotic and normal layers.…”
Section: Discussionsupporting
confidence: 93%
“…Skin eruptions may be the first symp tom of this disease for many months. Histopathologically NME is characterized by the presence of swelling and vacuolization of suprabasal cell layers and the abrupt change into parakeratotic material -a condi tion which is not seen in any other dermatosis [4,6,7].…”
Section: Discussionmentioning
confidence: 99%
“…Skin eruptions may be the first symp tom of this disease for many months. Histopathologically NME is characterized by the presence of swelling and vacuolization of suprabasal cell layers and the abrupt change into parakeratotic material -a condi tion which is not seen in any other dermatosis [4, 6, 7J. Our ultrastructural findings, which are consistent with previous reports [6,7], suggest that the degenera tive changes originate in the mid or upper epidermal layers, as kératinocytes in the lower layers are normal or show only regenerative hyperproliferation. Typical of NME are widened intercellular spaces, vacuoliza tion, cytolysis, dyskeratosis and parakeratosis, and a rather clear-cut demarcation between necrobiotic and normal layers.…”
Section: Discussionsupporting
confidence: 90%
“…Il a aussi été décrit chez des patients ayant subi d'autres interven tions chirurgicales, telles un Billroth II ou, en l'absence de toute chirurgie, en association avec différentes affections intestinales (recto-colite ulcéro-hémorragi-que, maladie de Crohn, diverticules du duodénum ou du jéjunum) [5][6][7]. Abstract.…”
Section: Commentaireunclassified
“…The main feature is a well-demarcated necrolysis ('sudden death') of the outer cell layers in the stratum Malpighii. Later, clefts and sepa ration occur at the site [15]. Such lesions could be easily interpreted as secondary to the accidental or factitial appli cation of a caustic substance to the skin.…”
Section: Introducing the Histopathological Concept Of Pseudo-factitiamentioning
confidence: 99%