1980
DOI: 10.1055/s-2007-1022104 View full text |Buy / Rent full text
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Abstract: During open-heart surgery, myocardial biopsies were taken from 31 patients undergoing aortic valve replacement on total cardiopulmonary bypass. The first needle biopsy was taken before the induction of cardiac arrest (Kirsch cardioplegia), the second at the end of global ischemia, and the third during the reperfusion period. The tissue was investigated by electron microscopy using a semiquantitative scoring system for changes in both myocytes and blood vessels. Mitochondrial volume and surface density were det… Show more

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“…Signs of extensive membrane defects can he revealed by electron microscopy after a shorter period of ischemia (14,29,38). This is because of (i) decreased energy level, (ii) failure of the Na § K+-pump causing disturbances in the cell volumen regulation, with pathological water-and ion shift and (iii) loss of membrane control of Ca2 § and sarcomere tension with irreversible myofibrillar contraction etc.…”
Section: Discussionmentioning
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“…Signs of extensive membrane defects can he revealed by electron microscopy after a shorter period of ischemia (14,29,38). This is because of (i) decreased energy level, (ii) failure of the Na § K+-pump causing disturbances in the cell volumen regulation, with pathological water-and ion shift and (iii) loss of membrane control of Ca2 § and sarcomere tension with irreversible myofibrillar contraction etc.…”
Section: Discussionmentioning
“…Functional, biochemical and morphological abnormalities caused by ischemic insults of the heart have been studied by many authors (5,13,14,15,16,24,29,38,39). Recent studies suggest that an oxygen-related phenomenon contributes to impairment of the ischemic heart and this has an important role in cardiac damage (11,12,18,22,35,40).…”
Section: Introductionmentioning
“…Of particular relevance to the heart’s function as a pump is the ability of the cardiomyocytes to supply themselves with the necessary energy for their work. During development in vivo, cardiomyocytes acquire a high density of mitochondria, which ultimately occupy 20%–30% of the cell volume in the adult (Schaper et al., 1980). This gives these cells a huge capacity for ATP synthesis, which is necessary to fund the high energy demands of ion pumping and contractility during strenuous activity.…”
Section: Introductionmentioning
“…However, endothelial ceils are among the most durable structures in infarction (28). Since oxygen radicals are short-lived substances it does not seem likely that they can travel far enough to reach more vulnerable structures before losing their reactivity (15,34).…”
Section: Discussionmentioning