Ultrastructural Changes in Zona Fasiculata Cells of Suprarenal Cortex in Adult Male Albino Rats after Short Exposure to High Ambient Temperature and the Effect of Fish Oil Administration

Mazroa, Shireen A.; Asker, Samar A.

doi:10.1097/00767537-201003000-00004

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2017

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“…Gesi et al [39] reported a marked increase of the cortisol levels in response to stressful stimuli such as noise or high ambient temperature that activated the hypothalamic pituitary adrenal axis leading to a release of ACTH. Similarly, other researchers [11,40] stated that immobilization stress response-related disorders resulted in the hypersecretion of both ACTH and corticosterone to a subsequent stressor.…”

Section: Discussionmentioning

confidence: 91%

“…Mazroa and Asker [11] found ultrastructural changes in zona fasciculata cells of rat adrenal cortex after exposure to high temperature stress.…”

Section: Introductionmentioning

confidence: 99%

Light and electron microscopic study on the effect of immobilization stress on adrenal cortex of adult rats and possible ameliorative role of vitamin E.

Altayeb

Salem

2017

Journal of Medical Histology

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Background: Modern society is full of stress. Immobilization stress is a model used in animals to study its effects. Vitamin E is an antioxidant that protects biological membranes from oxidative stress. Objectives: This study aimed to investigate the effects of immobilization stress on the adrenal cortex of rats and the ameliorative effect of vitamin E. Materials and Methods: Forty adult male rats were used in this study and were divided equally into 4 groups. Group I: were divided equally into negative and positive controls. Group II: rats received vitamin E at a dose of 40 I.U/kg by gastric tube for 30 days. Group III: rats subjected to immobilization stress 2 hours /day for 30 days. Group IV: rats subjected to immobilization stress 2 hours /day and received 40 I.U/kg of vitamin E for 30 days. Adrenal sections were histologically prepared and examined. Results: Group II was comparable to group IA. Group III revealed zona glomerulosa (ZG) with loss of normal architecture, zona fasciculata (ZF) with multiple cells containing cytoplasmic vacuolations and darkly stained nuclei. By EM ZG cells appeared with accumulations of lipid droplets and lysosomes, irregular nuclear envelopes and chromatin condensation. ZF cells showed numerous lipid droplets and irregular nuclear envelopes. There were significant increases in the mean area of collagen fibers and mean serum cortisol level. Group IV revealed regression of these changes and increase in the mean count of CD44 +ve cells. Conclusions: Immobilization stress exerted deleterious suprarenal cortical changes and vitamin E had an ameliorative effect.

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Ultrastructural Changes in Zona Fasiculata Cells of Suprarenal Cortex in Adult Male Albino Rats after Short Exposure to High Ambient Temperature and the Effect of Fish Oil Administration

Cited by 2 publications

References 2 publications

Light and electron microscopic study on the effect of immobilization stress on adrenal cortex of adult rats and possible ameliorative role of vitamin E.

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