Ultrasound: The versatile energy source

Haar, Gail ter

doi:10.3109/02656736.2015.1011716

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…In addition, it provides the flexibility of the FUS technology, where different piezoelectric crystal geometry, frequency, and power settings can be used to fine‐tune the size of the targeted region and the applied thermal and mechanical forces on tissues. FUS is also an attractive technology for translation into the clinic . Hence, our acoustofluidic platform could be a useful tool for investigating anticancer therapies that aim to maximize the therapeutic index by delivering high concentrations at the tumor core while minimizing exposure to adjacent healthy tissue (e.g., brain tumors).…”

Section: Discussionmentioning

confidence: 99%

Controlled Drug Release and Chemotherapy Response in a Novel Acoustofluidic 3D Tumor Platform

Zervantonakis

Arvanitis

2016

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Overcoming transport barriers to delivery of therapeutic agents in tumors remains a major challenge. Focused ultrasound (FUS), in combination with modern nanomedicine drug formulations, offers the ability to maximize drug transport to tumor tissue while minimizing toxicity to normal tissue. This potential remains unfulfilled due to the limitations of current approaches in accurately assessing and quantifying how FUS modulates drug transport in solid tumors. We developed a novel acoustofluidic platform by integrating a physiologically relevant 3D microfluidic device and a FUS system with a closed-loop controller to study drug transport and assess the response of cancer cells to chemotherapy in real time using live cell microscopy. FUS-induced heating triggered local release of the chemotherapeutic agent doxorubicin from a liposomal carrier and resulted in higher cellular drug uptake in the FUS focal region. This differential drug uptake induced locally confined DNA damage and glioblastoma tumor cell death in the 3D environment. Our study demonstrates the capabilities of acoustofluidics for accurate control of drug release and monitoring of localized cell response in a 3D in vitro tumor model and has important implications for developing novel strategies to deliver therapeutic agents directly to the tumor tissue while sparing healthy tissue.

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Section: Discussionmentioning

confidence: 99%

Controlled Drug Release and Chemotherapy Response in a Novel Acoustofluidic 3D Tumor Platform

Zervantonakis

Arvanitis

2016

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“…There is now a large body of evidence to show that not only can HIFU be used to induce hyperthermia, but also, when gas filled microbubbles are present, its mechanical action can enhance drug delivery and cause a temporary opening of the blood-brain barrier [9,16].…”

Section: High Intensity Focused Ultrasoundmentioning

confidence: 99%

Heat and sound: focused ultrasound in the clinic

Haar

2015

International Journal of Hyperthermia

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Ultrasound: The versatile energy source

Cited by 2 publications

References 19 publications

Controlled Drug Release and Chemotherapy Response in a Novel Acoustofluidic 3D Tumor Platform

Controlled Drug Release and Chemotherapy Response in a Novel Acoustofluidic 3D Tumor Platform

Heat and sound: focused ultrasound in the clinic

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