Ultrasound scattering properties of Albunex microspheres

Cavitation Threshold of Microbubbles in Gel Tunnels by Focused Ultrasound

“…At the level of basic physics research, efforts are concentrated in determining through experimentation and mathematical modeling the scattering properties and the bubble dynamics of the different kinds of UCAs, which differ for properties such as encapsulating shell, gas, and size distribution (de Jong and Hoff 1993;Guan and Matula 2004;Lo et al 2006;Marsh et al 1999;May et al 2002). A number of models have been proposed to describe the bubble dynamics in the presence of a shell, which are a modification of the free bubble equation, such as the Rayleigh-Plesset equation or the Gilmore equations, to include the shell properties Chatterjee and Sasaki 2003;Church 1995;Hoff et al 2000;Khismatullin and Nadim 2002).…”

Ultrasound contrast agents : dynamics of coated bubbles

“…Experiments on a representative sample of the UCA, containing many microbubbles, confirm the general trends and the influence of the bubble coating as predicted by the models. The resonance frequency is observed to shift to higher frequencies due to the shell stiffness and the extra damping introduced by the shell decreases the overall acoustic response [37,41,63].…”

“…To describe the radial dynamics of a phospholipid-coated microbubble, different models have been proposed [12,33,35,36,63]. In general, the phospholipid shell is assumed to increase the damping of the system and is taken into account through a shell viscosity κ s .…”

“…For coated bubbles the RP equation is extended with a set of shell parameters to model the rheological behavior of the viscoelastic coating. De Jong et al [63] introduced a shell stiffness parameter and a shell friction parameter for Albunex, a human serum albumin-coated microcapsule. Church [33] refined the physical modeling for Albunex, while Hoff et al [35] introduced a thin shell limit to model the phospholipid monolayer of Sonazoid, a second generation contrast agent.…”

Quantification of transpulmonary echocontrast effects

“…The calculated backscatter power is based on the expected size distribution and the theoretical model of an A1-bunex ® microsphere. This model theoretically describes the attenuation and scatter properties ofa microsphere (De Jong et al 1992;De Jong and Hoff 1993).…”