Ultrasound findings in pregnant women with uncomplicated vivax malaria in the Brazilian Amazon: a cohort study

Brock, M.; Miranda, Angélica Espinosa; Bôtto-Menezes, Camila; Leão, J.; Martínez-Espinosa, Flor Ernestina

doi:10.1186/s12936-015-0627-1

Cited by 6 publications

(6 citation statements)

References 46 publications

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“…This is a new finding. A study conducted in Brazil among pregnant women with vivax malaria reported no association of malaria and oligohydramnios [ 21 ]. However, it is worth noting that in the same study in Brazil, sonographic assessment done during the period of infection revealed thickened placentas with mal perfusion of the placentas, which may be a predisposing factor for oligohydramnios later in the pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and associated factors of oligohydramnios in pregnancies beyond 36 weeks of gestation at a tertiary hospital in southwestern Uganda

Twesigomwe

Migisha²,

Agaba³

et al. 2022

BMC Pregnancy Childbirth

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Background Oligohydramnios is associated with poor maternal and perinatal outcomes. In low-resource countries, including Uganda, oligohydramnios is under-detected due to the scarcity of ultrasonographic services. We determined the prevalence and associated factors of oligohydramnios among women with pregnancies beyond 36 weeks of gestation at Mbarara Regional Referral Hospital (MRRH) in Southwestern Uganda. Methods We conducted a hospital-based cross-sectional study from November 2019 to March 2020. Included were women at gestational age > 36 weeks. Excluded were women with ruptured membranes, those in active labour, and those with multiple pregnancies. An interviewer-administered structured questionnaire was used to capture demographic, obstetric, and clinical characteristics of the study participants. We determined oligohydramnios using an amniotic fluid index (AFI) obtained using an ultrasound scan. Oligohydramnios was diagnosed in participants with AFI ≤ 5 cm. We performed multivariable logistic regression to determine factors associated with oligohydramnios. Results We enrolled 426 women with a mean age of 27 (SD ± 5.3) years. Of the 426 participants, 40 had oligohydramnios, for a prevalence of 9.4% (95%CI: 6.8–12.6%). Factors found to be significantly associated with oligohydramnios were history of malaria in pregnancy (aOR = 4.6; 95%CI: 1.5–14, P = 0.008), primegravidity (aOR = 3.7; 95%CI: 1.6–6.7, P = 0.002) and increasing gestational age; compared to women at 37–39 weeks, those at 40–41 weeks (aOR = 2.5; 95%CI: 1.1–5.6, P = 0.022), and those at > 41 weeks (aOR = 6.0; 95%CI: 2.3–16, P = 0.001) were more likely to have oligohydramnios. Conclusion Oligohydramnios was detected in approximately one out of every ten women seeking care at MRRH, and it was more common among primigravidae, those with a history of malaria in pregnancy, and those with post-term pregnancies. We recommend increased surveillance for oligohydramnios in the third trimester, especially among prime gravidas, those with history of malaria in pregnancy, and those with post-term pregnancies, in order to enable prompt detection of this complication and plan timely interventions. Future longitudinal studies are needed to assess clinical outcomes in women with oligohydramnios in our setting.

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Section: Discussionmentioning

confidence: 99%

Prevalence and associated factors of oligohydramnios in pregnancies beyond 36 weeks of gestation at a tertiary hospital in southwestern Uganda

Twesigomwe

Migisha²,

Agaba³

et al. 2022

BMC Pregnancy Childbirth

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“… 1 In addition, in utero exposure to malaria parasites has been associated with a decreased head circumference (HC) among fetuses and newborns, a proportional decrease in size as an outcome of the intrauterine growth retardation. 3 , 4 , 5 , 6 …”

Section: Introductionmentioning

confidence: 99%

Association of Malaria Infection During Pregnancy With Head Circumference of Newborns in the Brazilian Amazon

et al. 2019

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Key Points Question Is malaria infection during pregnancy associated with fetal head growth? Findings In 2 cohort studies of 4291 pregnancies, falciparum malaria during pregnancy was significantly associated with the occurrence of decreased head circumference in newborns. Placental malaria characterized by increased placental syncytial nuclear aggregates, leukocyte infiltration, and imbalanced angiogenic factors was associated with the incidence of decreased head circumference. Meaning Plasmodium falciparum infection during pregnancy was associated with altered fetal head development, with possible consequences for fetal neurologic development.

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“…With the cessation of local malaria transmission in the country, disease surveillance along with entomological surveillance have been strengthened to prevent the re-introduction of malaria. The largest threat for re-introduction of malaria into the country is the importation of malaria cases from endemic countries [ 4 ]. The influx of malaria parasites into the country are through security personnel returning from United Nations peace missions, asylum seekers coming through United Nations High Commissioner for Refugees (UNHCR), foreign workforces in different trades, and local migrants going to malarious countries on travel, business or pilgrimage.…”

Section: Introductionmentioning

confidence: 99%

First record of Anopheles stephensi in Sri Lanka: a potential challenge for prevention of malaria reintroduction

Dharmasiri

Perera

Harishchandra

et al. 2017

Malar J

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BackgroundThe major malaria vector in Sri Lanka is reported to be Anopheles culicifacies with Anopheles subpictus, Anopheles annularis, and Anopheles varuna considered as potential vectors. The occurrence of Anopheles stephensi, which is the key vector of urban malaria in India and the Middle East, had never been reported from Sri Lanka.MethodsA series of entomological investigations were carried out by the Anti Malaria Campaign, Ministry of Health, Sri Lanka during December 2016 to April 2017 in two localities of the Mannar District in the Northern Province of the country. Adult mosquito collections were done through indoor and outdoor resting collections, animal and human biting collections and emergence traps. Potential mosquito breeding sites were investigated through larval surveys. The larvae and adults of An. stephensi were initially identified using morphological keys, and subsequently confirmed by sequencing the barcode region of the cytochrome c oxidase I (COI) gene.ResultsThis is the first report of the presence of An. stephensi in the island of Mannar in the Northern Province of Sri Lanka. Anopheles stephensi (36.65%) was the most abundant anopheline species in the larval habitats in Mannar. It was found breeding together with An. culicifacies (20.7%), An. subpictus (13.5%) and An. varuna (28.13%). Anopheles stephensi was found to be abundantly breeding in built wells used for domestic purposes. Adult females of An. stephensi were observed in emergence trap collections (93.9%), human landing catches all night (79.2%), pyrethrum spray sheet collections (38.6%), outdoor collections (8.3%), donkey-baited trap collections (14.3), and cattle-baited net trap collections (0.7%).ConclusionsSri Lanka was certified as malaria-free by the WHO in September 2016, however, this new finding may pose a serious challenge to the efforts of the Ministry of Health to prevent the re-introduction of malaria transmission in the country, considering the role that An. stephensi could play in urban and high vulnerability areas of Sri Lanka.

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Ultrasound findings in pregnant women with uncomplicated vivax malaria in the Brazilian Amazon: a cohort study

Cited by 6 publications

References 46 publications

Prevalence and associated factors of oligohydramnios in pregnancies beyond 36 weeks of gestation at a tertiary hospital in southwestern Uganda

Prevalence and associated factors of oligohydramnios in pregnancies beyond 36 weeks of gestation at a tertiary hospital in southwestern Uganda

Association of Malaria Infection During Pregnancy With Head Circumference of Newborns in the Brazilian Amazon

First record of Anopheles stephensi in Sri Lanka: a potential challenge for prevention of malaria reintroduction

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