Ultrasound cascade regulation of nano-oxygen hybrids triggering ferroptosis augmented sonodynamic anticancer therapy

Sun, Yue; Wang, Yihui; Han, Ruyin; Ren, Ziwei; Chen, Xin; Dong, Wenzhuo; Choi, Stephen; Liu, Quanhong; Wang, Xiaobing

doi:10.1007/s12274-023-5377-0

Cited by 9 publications

(1 citation statement)

References 52 publications

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“…Sun et al designed an integrated nano-oxygen carrier through the combination of hemoglobin (Hb), sinoporphyrin sodium (DVDMS), and TiO 2 , enabling this nanoplatform to inhibit tumor progression through SDT and ferroptosis induction. 279 The iron-transfer function of Hb is critical to its performance in ferroptosis induction, which further inspires us to comprehensively consider the biological functions of nanomaterials. Promoted by the progression of nanotechnology, numerous innovations in US-based ROS-generating nanoplatforms have been applied to enhance SDT performance in tumor therapy.…”

Section: Rxs-generating Nanomedicinementioning

confidence: 99%

Reactive X (where X = O, N, S, C, Cl, Br, and I) species nanomedicine

Wang,

Mao,

Song

et al. 2023

Chem. Soc. Rev.

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Section: Rxs-generating Nanomedicinementioning

confidence: 99%

Reactive X (where X = O, N, S, C, Cl, Br, and I) species nanomedicine

Wang,

Mao,

Song

et al. 2023

Chem. Soc. Rev.

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Tumor Microenvironment‐Activatable Metal‐Phenolic Nanoformulations for Ultrasound‐Boosted Ferroptosis through Triple Regulatory Pathways

Liu,

Liu

et al. 2024

Adv Funct Materials

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Despite its effectiveness in exterminating tumor cells, ferroptosis is seriously hampered by the high expression of antioxidant glutathione (GSH) and the inadequacy of endogenous H2O2 in tumors. Herein, metal‐phenolic nanoformulations (FNCP NFs) composed of sonosensitizer Chlorin e6 (Ce6), the phenolic GSH consumer naphthazarin, and Fe3+, followed by the modification of PEG2000, are strategically designed and fabricated for ultrasound‐boosted ferroptosis in tumor cells through triple regulatory pathways. The carrier‐free FNCP NFs can rapidly dissociate under tumor microenvironment response with the assistance of ultrasound, releasing Fe2+, Ce6, and naphthazarin. Ce6 and Fe2+ are capable of producing singlet oxygen (1O2) and hydroxyl radicals (·OH) by ultrasound‐activated sonodynamic therapy and Fenton reaction‐mediated chemodynamic therapy (CDT), respectively, which not only induce apoptotic cell death but also lead to the effective accumulation of lipid peroxidation (LPO), resulting in ferroptosis. Meanwhile, the released naphthazarin and the self‐cycling valence alternations of Fe3+/Fe2+ promote the significant decrease of intracellular GSH contents, further inducing the inactivation of glutathione peroxidase 4 (GPX4) and the up‐regulation of LPO levels, eventually realizing the synergistically enhanced ferroptosis. This facile and feasible design for versatile metal‐phenolic nanoformulations offers a new strategy for effectively improving ferroptosis efficiency and multimodal cancer therapies.

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Engineering Sonosensitizer‐Derived Nanotheranostics for Augmented Sonodynamic Therapy

Yang,

Lv,

et al. 2024

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Sonodynamic therapy (SDT), featuring noninvasive, deeper penetration, low cost, and repeatability, is a promising therapy approach for deep‐seated tumors. However, the general or only utilization of SDT shows low efficiency and unsatisfactory treatment outcomes due to the complicated tumor microenvironment (TME) and SDT process. To circumvent the issues, three feasible approaches for enhancing SDT‐based therapeutic effects, including sonosensitizer optimization, strategies for conquering hypoxia TME, and combinational therapy are summarized, with a particular focus on the combination therapy of SDT with other therapy modalities, including chemodynamic therapy, photodynamic therapy, photothermal therapy, chemotherapy, starvation therapy, gas therapy, and immunotherapy. In the end, the current challenges in SDT‐based therapy on tumors are discussed and feasible approaches for enhanced therapeutic effects are provided. It is envisioned that this review will provide new insight into the strategic design of high‐efficiency sonosensitizer‐derived nanotheranostics, thereby augmenting SDT and accelerating the potential clinical transformation.

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Ultrasound cascade regulation of nano-oxygen hybrids triggering ferroptosis augmented sonodynamic anticancer therapy

Cited by 9 publications

References 52 publications

Reactive X (where X = O, N, S, C, Cl, Br, and I) species nanomedicine

Reactive X (where X = O, N, S, C, Cl, Br, and I) species nanomedicine

Tumor Microenvironment‐Activatable Metal‐Phenolic Nanoformulations for Ultrasound‐Boosted Ferroptosis through Triple Regulatory Pathways

Engineering Sonosensitizer‐Derived Nanotheranostics for Augmented Sonodynamic Therapy

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