Ultrafast Multidimensional Laplace NMR Using a Single‐Sided Magnet

King, Jared N.; Lee, Vanessa J; Ahola, Sakari; Telkki, Ville‐Veikko; Meldrum, Tyler

doi:10.1002/anie.201511859

Cited by 36 publications

(31 citation statements)

References 40 publications

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“…[18][19][20] and now the P2DRM, opens the possibility for investigation of time-sensitive processes. Recently, a novel single-scan version of the T 1 -T 2 correlation pulse sequence has been developed, where the T 1 kernel is encoded along the direction of an applied gradient during an adiabatic frequency sweep π pulse and then retrieved by Fourier transform of the echoes acquired under a read gradient [18,19]. However, a full T 1 -T 2 correlation measurement may not be necessary for porous media applications, and the P2DRM may offer a more simple interpretation by framing the results in terms of the utilized prior knowledge.…”

Section: Introductionmentioning

confidence: 99%

Obtaining T 1 - T 2 distribution functions from 1-dimensional T 1 and T 2 measurements: The pseudo 2-D relaxation model

Williamson

Röding

Galvosas

et al. 2016

Journal of Magnetic Resonance

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We present the pseudo 2-D relaxation model (P2DRM), a method to estimate multidimensional probability distributions of material parameters from independent 1-D measurements. We illustrate its use on 1-D T1 and T2 relaxation measurements of saturated rock and evaluate it on both simulated and experimental T1-T2 correlation measurement data sets. Results were in excellent agreement with the actual, known 2-D distribution in the case of the simulated data set. In both the simulated and experimental case, the functional relationships between T1 and T2 were in good agreement with the T1-T2 correlation maps from the 2-D inverse Laplace transform of the full 2-D data sets. When a 1-D CPMG experiment is combined with a rapid T1 measurement, the P2DRM provides a double-shot method for obtaining a T1-T2 relationship, with significantly decreased experimental time in comparison to the full T1-T2 correlation measurement.

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Section: Introductionmentioning

confidence: 99%

Obtaining T 1 - T 2 distribution functions from 1-dimensional T 1 and T 2 measurements: The pseudo 2-D relaxation model

Williamson

Röding

Galvosas

et al. 2016

Journal of Magnetic Resonance

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“…Contrary to UF‐PGSTE experiment, UF‐PGSE produces artifact‐free data with a single‐scan, providing significant prospects for monitoring fast processes in real time. Spatial encoding lowers the sensitivity of the experiment, typically by factor of four, but signal‐to‐noise ratio per unit time may be increased, because multiple scans can be collected in the experiment time of the conventional experiment . The single‐scan approach also enables one to use hyperpolarized substances to boost the sensitivity by several orders of magnitude, allowing the studies of samples with low concentration.…”

Section: Discussionmentioning

confidence: 99%

“…Spatial encoding lowers the sensitivity of the experiment, typically by factor of four, [38] but signal-to-noise ratio per unit time may be increased, because multiple scans can be collected in the experiment time of the conventional experiment. [38,42] The single-scan approach also enables one to use hyperpolarized substances to boost the sensitivity by several orders of magnitude, [38] allowing the studies of samples with low concentration. A rigorous theoretical analysis of the echo amplitude in UF-PGSE and UF-PGSTE experiment justified the theoretical basis of the methods and revealed that the conventional exponential fit to the experimental data leads to diffusion coefficient values overestimated by a few per cent.…”

Section: Discussionmentioning

confidence: 99%

Ultrafast NMR diffusion measurements exploiting chirp spin echoes

Ahola

Mankinen

Telkki

2016

Magnetic Reson in Chemistry

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Standard diffusion NMR measurements require the repetition of the experiment multiple times with varying gradient strength or diffusion delay. This makes the experiment time-consuming and restricts the use of hyperpolarized substances to boost sensitivity. We propose a novel single-scan diffusion experiment, which is based on spatial encoding of two-dimensional data, employing the spin-echoes created by two successive adiabatic frequency-swept chirp  pulses. The experiment is called ultrafast pulsed-field-gradient spin-echo (UF-PGSE). We present a rigorous derivation of the echo amplitude in the UF-PGSE experiment, justifying the theoretical basis of the method. The theory reveals also that the standard analysis of experimental data leads to a diffusion coefficient value overestimated by a few per cent. Although the overestimation is of the order of experimental error and thus insignificant in many practical applications, we propose that it can be compensated by a bipolar gradient version of the experiment, UF-BP-PGSE, or by corresponding stimulatedecho experiment, UF-BP-PGSTE. The latter also removes the effect of uniform background gradients. The experiments offer significant prospects for monitoring fast processes in real-time as well as for increasing the sensitivity of experiments by several orders of magnitude by nuclear spin hyperpolarization. Furthermore, they can be applied as basic blocks in various ultrafast multidimensional Laplace NMR experiments.

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“…, for the investigation of dynamics and physical environments of HP gases in porous media, both with high-field and low-field (mobile) NMR instruments. [236–237] …”

Section: Remote-detection Mri Of Hyperpolarized Gasesmentioning

confidence: 99%

NMR Hyperpolarization Techniques of Gases

Barskiy

Coffey

Nikolaou

et al. 2016

Chemistry A European J

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153

117

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Nuclear spin polarization can be significantly increased through the process of hyperpolarization, leading to an increase in the sensitivity of nuclear magnetic resonance (NMR) experiments by 4–8 orders of magnitude. Hyperpolarized gases, unlike liquids and solids, can be more readily separated and purified from the compounds used to mediate the hyperpolarization processes. These pure hyperpolarized gases enabled many novel MRI applications including the visualization of void spaces, imaging of lung function, and remote detection. Additionally, hyperpolarized gases can be dissolved in liquids and can be used as sensitive molecular probes and reporters. This mini-review covers the fundamentals of the preparation of hyperpolarized gases and focuses on selected applications of interest to biomedicine and materials science.

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Ultrafast Multidimensional Laplace NMR Using a Single‐Sided Magnet

Cited by 36 publications

References 40 publications

Obtaining T 1 - T 2 distribution functions from 1-dimensional T 1 and T 2 measurements: The pseudo 2-D relaxation model

Obtaining T 1 - T 2 distribution functions from 1-dimensional T 1 and T 2 measurements: The pseudo 2-D relaxation model

Ultrafast NMR diffusion measurements exploiting chirp spin echoes

NMR Hyperpolarization Techniques of Gases

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