Ultra-thin, gas permeable free-standing and composite membranes for microfluidic lung assist devices

Sreenivasan, R.; Bassett, Erik K.; Hoganson, David M.; Vacanti, Joseph P.; Gleason, Karen K.

doi:10.1016/j.biomaterials.2011.02.017

Cited by 47 publications

(35 citation statements)

References 26 publications

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“…From this, lung assist microdevices that utilize vascular networks are being designed, with the hopes that they can be implanted in the patient. [ 30 ] Sreenivasan et al [ 31 ] developed a lung assist device that is designed to achieve physiologic fl ow through utilizing microfl uidic vascular networks, which may allow this device to be implanted if it is impermeable to fl uid. Sreenivasan et al aimed to improve their previous 8 µm silicon membrane by designing the gas exchange membrane to be more permeable.…”

Section: Reviewmentioning

confidence: 99%

“…Human alveolar epithelial/microvascular endothelial cells [7] Observing cellular injury through both solid and fl uid mechanical stress A549, AEC [28] Producing suitable levels of gas transfer for artifi cial lung applications N/A [29] Gaseous exchange in vascular network through creation of free-standing membranes N/A [31] Optimizing fl ow and gaseous exchange through use of a vascular scaffold N/A [30] Intestine Toxicity/Drug Testing µCCA model to study GI tract and predict drug toxicity Caco-2 and HepG2/C3A [36] Testing drug permeability in the intestinal epithelial cell membrane through use of microhole trapping Caco-2 [44] Functional analysis Use of hydrogels as a platform for cultivated cells in a GI tract design Caco-2 [38] Functional model for potential integration in a body-on-a-chip design Analyzing signals through bacteria-cell interaction in GI tract HeLa S3 [39] Effects of shear stress, monocyte-EC adhesion, and monocyte transmigration on a vasculature system PAEC, RAW264.7, THP-1 [66] Bone Marrow Toxicity/Drug Testing Radiation-induced toxicity effects on a bone marrow-on-a-chip hematopoietic and adipocyte cells [67] Cancer/Tumor Toxicity/Drug Testing Studying chemotherapy resistance using a lung cancer microfl uidic model Recreating prostate cancer microenvironment using fl uid shear stress…”

Section: Reviewmentioning

confidence: 99%

See 1 more Smart Citation

Microfluidic Organ‐on‐a‐Chip Technology for Advancement of Drug Development and Toxicology

Caplin

Granados

James

et al. 2015

Adv Healthcare Materials

178

124

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In recent years, the exploitation of phenomena surrounding microfluidics has seen an increase in popularity, as researchers have found a way to use their unique properties to create superior design alternatives. One such application is representing the properties and functions of different organs on a microscale chip for the purpose of drug testing or tissue engineering. With the introduction of "organ-on-a-chip" systems, researchers have proposed various methods on various organ-on-a-chip systems to mimic their in vivo counterparts. In this article, a systematic approach is taken to review current technologies pertaining to organ-on-a-chip systems. Design processes with attention to the particular instruments, cells, and materials used are presented.

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Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Microfluidic Organ‐on‐a‐Chip Technology for Advancement of Drug Development and Toxicology

Caplin

Granados

James

et al. 2015

Adv Healthcare Materials

178

124

View full text Add to dashboard Cite

show abstract

“…Bond failure typically occurred at the inlet or outlet because those areas had the largest unbonded span that resulted in the greatest stress on the bond. Both dry and wet burst pressures for all bonded samples were well above 500 mmHg, 25 times higher than the maximum expected pressure (19 mmHg) in current lung assist devices (Hoganson et al 2010;Sreenivasan et al 2011). Even the porous PTFE membranes (Fig.…”

Section: Resultsmentioning

confidence: 90%

Solvent-free surface modification by initiated chemical vapor deposition to render plasma bonding capabilities to surfaces

Sreenivasan

Bassett

Cervantes

et al. 2011

Microfluid Nanofluid

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A versatile solvent-free method for surface modification of various materials including both metals and polymers is described. Strong irreversible bonds were formed when substrates modified by initiated chemical vapor deposition (iCVD) of poly(1,3,5-trivinyltrimethylcyclotrisiloxane) or poly(V3D3) and exposed to an oxygen plasma were brought into contact with plasma-treated poly(dimethylsiloxane) (PDMS). The strength of these bonds was quantified by burst pressure testing microfluidic channels in the PDMS. The burst pressures of PDMS bonded to various coated substrates were in some cases comparable to that of PDMS bonded directly to PDMS. In addition, porous PTFE membrane coated with poly(V3D3) was successfully bonded to a PDMS microfluidic device and withstood pressures of over 300 mmHg. Bond strength was shown to correlate with surface roughness and quality of the bond between the coating and substrate. This work paves a methodology to fabricate microfluidic devices that include a specifically tailored membrane. Furthermore, the bonded devices exhibited hydrolytic stability; no dramatic change was observed even after immersion in water at room temperature over a period of 10 days.

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“…Such selectivity has been demonstrated using freestanding iCVD membranes. [ 65 ] These membranes were also integrated into microfl uidic devices possessing a vascular network, as shown in Figure 3 b. [ 66 ] iCVD coatings have also been used to enhance selective permeation of commercially available membranes.…”

Section: Selective Permeationmentioning

confidence: 99%

Chemical Vapor Deposition for Solvent‐Free Polymerization at Surfaces

Yagüe

Coclite

Petruczok

et al. 2012

Macro Chemistry & Physics

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Chemical vapor deposition (CVD) methods are a powerful technology for engineering surfaces. When CVD is combined with the richness of organic chemistry, the resulting polymeric coatings, deposited without solvents, represent an enabling technology in many different fi elds of application. This article focuses on initiated chemical vapor deposition (iCVD), a new technique that utilizes benign reaction conditions to yield conformal and functional polymer thin fi lms. The latest achievements in coating surfaces and 3D substrates with functional materials, and the use of the technique for biotechnology and selective permeation applications are reviewed, and future directions for iCVD technology are discussed.

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Ultra-thin, gas permeable free-standing and composite membranes for microfluidic lung assist devices

Cited by 47 publications

References 26 publications

Microfluidic Organ‐on‐a‐Chip Technology for Advancement of Drug Development and Toxicology

Microfluidic Organ‐on‐a‐Chip Technology for Advancement of Drug Development and Toxicology

Solvent-free surface modification by initiated chemical vapor deposition to render plasma bonding capabilities to surfaces

Chemical Vapor Deposition for Solvent‐Free Polymerization at Surfaces

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