Ultra-large-scale production of ultrasmall superparamagnetic iron oxide nanoparticles for T<sub>1</sub>-weighted MRI

Rui, Yuanpeng; Liang, Bo; Hu, Fenglin; Xu, Jie; Peng, Yifeng; Yin, Peihao; Duan, Yourong; Zhang, Chunfu; Gu, Hongchen

doi:10.1039/c6ra00347h

Cited by 40 publications

(34 citation statements)

References 58 publications

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“…The positions of the peaks indicate attachment of the polymer ligand to the surface of the maghemite nanoparticles through carboxylate groups. In the species –COO–Fe, these are shifted to slightly higher energies compared to non-attached carboxylates [57–58]. The peaks at 2850 cm −1 , 2920 cm −1 , and 2960 cm −1 are assigned to C–H stretching vibrations in the PAA chain.…”

Section: Resultsmentioning

confidence: 99%

Tungsten disulfide-based nanocomposites for photothermal therapy

Levin¹,

Sade²,

Binyamini³

et al. 2019

Beilstein J. Nanotechnol.

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Nanostructures of transition-metal dichalcogenides (TMDC) have raised scientific interest in the last few decades. Tungsten disulfide (WS2) nanotubes and nanoparticles are among the most extensively studied members in this group, and are used for, e.g., polymer reinforcement, lubrication and electronic devices. Their biocompatibility and low toxicity make them suitable for medical and biological applications. One potential application is photothermal therapy (PTT), a method for the targeted treatment of cancer, in which a light-responsive material is irradiated with a laser in the near-infrared range. In the current article we present WS2 nanotubes functionalized with previously reported ceric ammonium nitrate–maghemite (CAN-mag) nanoparticles, used for PTT. Functionalization of the nanotubes with CAN-mag nanoparticles resulted in a magnetic nanocomposite. When tested in vitro with two types of cancer cells, the functionalized nanotubes showed a better PTT activity compared to non-functionalized nanotubes, as well as reduced aggregation and the ability to add a second-step functionality. This ability is demonstrated here with two polymers grafted onto the nanocomposite surface, and other functionalities could be additional cancer therapy agents for achieving increased therapeutic activity.

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Section: Resultsmentioning

confidence: 99%

Tungsten disulfide-based nanocomposites for photothermal therapy

Levin¹,

Sade²,

Binyamini³

et al. 2019

Beilstein J. Nanotechnol.

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“…Major organs (heart, liver, spleen, lung, and kidney) from each treatment group were harvested when mice died or after mice were sacrificed (SWNHs/C 18 PMH/mPEG-PLA-DOX-Pt + laser group). For histological examination, the organs were fixed in 4% formalin, imbedded in paraffin, and processed for hematoxylin and eosin (H&E) (Aladdin, Ontario, CA, USA) staining according to the protocol provided by the manufacturer and previous reports 75 . Tissue slices were examined under a digital microscope (Nikon ECLIPSE Ti-E, Tokyo, Japan).…”

Section: Methodsmentioning

confidence: 99%

Dual Chemodrug-Loaded Single-Walled Carbon Nanohorns for Multimodal Imaging-Guided Chemo-Photothermal Therapy of Tumors and Lung Metastases

Yang

Sun

et al. 2018

Theranostics

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Tumor combination therapy using nano formulations with multimodal synergistic therapeutic effects shows great potential for complete ablation of tumors. However, targeting tumor metastases with nano structures is a major obstacle for therapy. Therefore, developing a combination therapy system able to target both primary tumors and their metastases at distant sites with synergistic therapy is desirable for the complete eradication of tumors. To this end, a dual chemodrug-loaded theranostic system based on single walled carbon nanohorns (SWNHs) is developed for targeting both primary breast tumors and their lung metastases.Methods: SWNHs were first modified simultaneously with poly (maleic anhydride-alt-1-octadecene) (C18PMH) and methoxypolyethyleneglycol-b-poly-D, L-lactide (mPEG-PLA) via hydrophobic-hydrophobic interactions and π-π stacking. Then cisplatin and doxorubicin (DOX) (2.9:1 molar ratio) were sequentially loaded onto the modified nanohorns in a noninterfering way. After careful examinations of the release profiles of the loaded drugs and the photothermal performance of the dual chemodrug-loaded SWNHs, termed SWNHs/C18PMH/mPEG-PLA-DOX-Pt, the dual drug chemotherapeutic and chemo-photothermal synergetic therapeutic effects on tumor cells were evaluated. Subsequently, the in vivo behavior and tumor accumulation of the drug-loaded SWNHs were studied by photoacoustic imaging (PAI). For chemo-photothermal therapy of tumors, 4T1 tumor bearing mice were intravenously injected with SWNHs/C18PMH/mPEG-PLA-DOX-Pt at a dose of 10 mg/kg b.w. (in SWNHs) and tumors were illuminated by an 808 nm laser (1W/cm2 for 5 min) 24 h post-injection.Results: DOX and cisplatin were loaded onto the modified SWNHs with high efficiency (44 wt% and 66 wt%, respectively) and released in a pH-sensitive, tandem and sustainable manner. The SWNHs/C18PMH/mPEG-PLA-DOX-Pt had a hydrodynamic diameter of 182 ± 3.2 nm, were highly stable in physiological environment, and had both dual drug chemotherapeutic (CI = 0.439) and chemo-photothermal synergistic antitumor effects (CI = 0.396) in vitro. Moreover, the dual drug-loaded SWNHs had a long blood half-life (10.9 h) and could address both the primary breast tumors and their lung metastases after intravenous administration. Consequently, chemo-photothermal combination therapy ablated the primary tumors and simultaneously eradicated the metastatic lung nodules.Conclusion: Our study demonstrates that SWNHs/C18PMH/mPEG-PLA-DOX-Pt is highly potent for chemo-photothermal combination therapy of primary tumors and cocktail chemotherapy of their metastases at a distant site.

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“…USPIOs coated with polyacrylic acid (PAA@USPIOs) were synthesized via a polyol method according to our previous reports. 28 For preparation of RGD-99m Tc-PAA@USPIOs, PAA@USPIOs were rst modied with ethylene diamine. Specically, PAA@USPIOs (4.5 mg) and ethylene diamine (13.5 mg) were mixed into 2-(N-morpholino)ethanesulfonic acid (MES) buffer (3 mL, pH ¼ 4.5).…”

Section: Methodsmentioning

confidence: 99%

“…27 Recently, we have developed a novel approach to produce polyacrylic acid (PAA) coated USPIOs (PAA@USPIOs) in large scale. 28 The PAA@USPIOs (around 4.5 nm) have a superior T 1 contrast effect and are highly effective for MRI angiography. However, whether USPIOs with good T 1 contrast effect could be used for receptor-targeted, T 1 -weighted MR molecular imaging is still unknown and few works have been performed in this regard.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of USPIOs for T₁-weighted MR molecular imaging of tumor receptors

Liu

Cai

et al. 2017

RSC Adv.

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Ultra-large-scale production of ultrasmall superparamagnetic iron oxide nanoparticles for T₁-weighted MRI

Abstract: Ultra-large-scale production of ultrasmall superparamagnetic iron oxide nanoparticles for magnetic resonance angiography.

Cited by 40 publications

References 58 publications

Tungsten disulfide-based nanocomposites for photothermal therapy

Tungsten disulfide-based nanocomposites for photothermal therapy

Dual Chemodrug-Loaded Single-Walled Carbon Nanohorns for Multimodal Imaging-Guided Chemo-Photothermal Therapy of Tumors and Lung Metastases

Feasibility of USPIOs for T₁-weighted MR molecular imaging of tumor receptors

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Ultra-large-scale production of ultrasmall superparamagnetic iron oxide nanoparticles for T1-weighted MRI

Abstract: Ultra-large-scale production of ultrasmall superparamagnetic iron oxide nanoparticles for magnetic resonance angiography.

Cited by 40 publications

References 58 publications

Tungsten disulfide-based nanocomposites for photothermal therapy

Tungsten disulfide-based nanocomposites for photothermal therapy

Dual Chemodrug-Loaded Single-Walled Carbon Nanohorns for Multimodal Imaging-Guided Chemo-Photothermal Therapy of Tumors and Lung Metastases

Feasibility of USPIOs for T1-weighted MR molecular imaging of tumor receptors

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Ultra-large-scale production of ultrasmall superparamagnetic iron oxide nanoparticles for T₁-weighted MRI

Feasibility of USPIOs for T₁-weighted MR molecular imaging of tumor receptors