Ulipristal acetate: a novel pharmacological approach for the treatment of uterine fibroids

DNA methylation of ICAM4 and NOXO1 participate in the formation of uterine fibroids via regulating immune cell infiltration

“…Since early growth response gene-1 (EGR1) was mainly reported to be significantly down-regulated in uterine fibroids, cluster 2 seems to be an unusual subtype. It's worth noting that FOSB was significantly up-regulated in cluster 2, which is consistent with the study made by Pilgrim et al (30) FOSB was related to mechanical stretch, for example, Ramachandran et al (31) found that, when suffering mechanical stretch, FOSB in the bladder smooth muscle would up-regulate and cause the expression of ECM proteins up-regulate. Recently, Mitchell et al (32) revealed that static stretch in rat myometrial smooth muscle can lead to increased expression of FOSB.…”

“…Recently, Mitchell et al (32) revealed that static stretch in rat myometrial smooth muscle can lead to increased expression of FOSB. After induced by stretch or stress, up-regulated FOSB could participate in the mechano-transduction of uterine fibroids (31). This mechano-transduction may facilitate fibrosis, cause enhancive collagen 1A deposition, and attenuated fibronectin deposition.…”

DNA methylation of ICAM4 and NOXO1 participate in the formation of uterine fibroids via regulating immune cell infiltration

“…Since early growth response gene-1 (EGR1) was mainly reported to be significantly down-regulated in uterine fibroids, cluster 2 seems to be an unusual subtype. It's worth noting that FOSB was significantly up-regulated in cluster 2, which is consistent with the study made by Pilgrim et al (30) FOSB was related to mechanical stretch, for example, Ramachandran et al (31) found that, when suffering mechanical stretch, FOSB in the bladder smooth muscle would up-regulate and cause the expression of ECM proteins up-regulate. Recently, Mitchell et al (32) revealed that static stretch in rat myometrial smooth muscle can lead to increased expression of FOSB.…”

“…Recently, Mitchell et al (32) revealed that static stretch in rat myometrial smooth muscle can lead to increased expression of FOSB. After induced by stretch or stress, up-regulated FOSB could participate in the mechano-transduction of uterine fibroids (31). This mechano-transduction may facilitate fibrosis, cause enhancive collagen 1A deposition, and attenuated fibronectin deposition.…”

Impact of Contraception on Uterine Fibroids

“…Moreover, UPA down regulates the expression of angiogenic growth factors, such as vascular endothelial growth factor (VEGF) and their receptors. Thus, it suppresses neo-vascularization, cell proliferation and survival in leiomyoma cells but not in normal myometrial cells [ 33 ]. Earlier studies in fibroid research demonstrated that cultured leiomyoma cells responded to 100 ng/mL of UPA (also known as CDB-2914; CDB-2914 (17α-acetoxy-11β-[4- N , N -dimethylaminophenyl]-19-norpregna-4,9-diene-3,20-dione) by regulating progesterone receptor (PR) isoforms [ 34 ].…”

Effect of ulipristal acetate on leomyoma of uterus

“…Fibroid volume shrank by 21% in the 5 mg group and 12% in the 10 mg group but increased by 3% in the placebo group. 4 Uterine bleeding was controlled in 90% of patients receiving 5 mg of UPA, in 98% of those receiving 10 mg of UPA, and in 89% of those receiving leuprolide acetate. Median times to amenorrhea were 7 days for patients receiving 5 mg of UPA, 5 days for those receiving 10 mg of UPA, and 21 days for those receiving leuprolide acetate.…”

“…It keeps oestradiol levels at mid follicular phase range, theirby reducing the incidence of hot flushes and exerting no impact on bone turnover. 4 There are several study about UPA. In one study patients were randomised to receive UPA 5 mg/day (96 women) or UPA 10 mg/day (98 women) or placebo (48 women).…”

DNA methylation of ICAM4 and NOXO1 participate in the formation of uterine fibroids via regulating immune cell infiltration

“…Since early growth response gene-1 (EGR1) was mainly reported to be significantly down-regulated in uterine fibroids, cluster 2 seems to be an unusual subtype. It's worth noting that FOSB was significantly up-regulated in cluster 2, which is consistent with the study made by Pilgrim et al (30) FOSB was related to mechanical stretch, for example, Ramachandran et al (31) found that, when suffering mechanical stretch, FOSB in the bladder smooth muscle would up-regulate and cause the expression of ECM proteins up-regulate. Recently, Mitchell et al (32) revealed that static stretch in rat myometrial smooth muscle can lead to increased expression of FOSB.…”

“…Recently, Mitchell et al (32) revealed that static stretch in rat myometrial smooth muscle can lead to increased expression of FOSB. After induced by stretch or stress, up-regulated FOSB could participate in the mechano-transduction of uterine fibroids (31). This mechano-transduction may facilitate fibrosis, cause enhancive collagen 1A deposition, and attenuated fibronectin deposition.…”

Impact of Contraception on Uterine Fibroids

“…Moreover, UPA down regulates the expression of angiogenic growth factors, such as vascular endothelial growth factor (VEGF) and their receptors. Thus, it suppresses neo-vascularization, cell proliferation and survival in leiomyoma cells but not in normal myometrial cells [ 33 ]. Earlier studies in fibroid research demonstrated that cultured leiomyoma cells responded to 100 ng/mL of UPA (also known as CDB-2914; CDB-2914 (17α-acetoxy-11β-[4- N , N -dimethylaminophenyl]-19-norpregna-4,9-diene-3,20-dione) by regulating progesterone receptor (PR) isoforms [ 34 ].…”

Effect of ulipristal acetate on leomyoma of uterus

“…Fibroid volume shrank by 21% in the 5 mg group and 12% in the 10 mg group but increased by 3% in the placebo group. 4 Uterine bleeding was controlled in 90% of patients receiving 5 mg of UPA, in 98% of those receiving 10 mg of UPA, and in 89% of those receiving leuprolide acetate. Median times to amenorrhea were 7 days for patients receiving 5 mg of UPA, 5 days for those receiving 10 mg of UPA, and 21 days for those receiving leuprolide acetate.…”

“…It keeps oestradiol levels at mid follicular phase range, theirby reducing the incidence of hot flushes and exerting no impact on bone turnover. 4 There are several study about UPA. In one study patients were randomised to receive UPA 5 mg/day (96 women) or UPA 10 mg/day (98 women) or placebo (48 women).…”

DNA methylation of ICAM4 and NOXO1 participate in the formation of uterine fibroids via regulating immune cell infiltration

“…Since early growth response gene-1 (EGR1) was mainly reported to be significantly down-regulated in uterine fibroids, cluster 2 seems to be an unusual subtype. It's worth noting that FOSB was significantly up-regulated in cluster 2, which is consistent with the study made by Pilgrim et al (30) FOSB was related to mechanical stretch, for example, Ramachandran et al (31) found that, when suffering mechanical stretch, FOSB in the bladder smooth muscle would up-regulate and cause the expression of ECM proteins up-regulate. Recently, Mitchell et al (32) revealed that static stretch in rat myometrial smooth muscle can lead to increased expression of FOSB.…”

“…Recently, Mitchell et al (32) revealed that static stretch in rat myometrial smooth muscle can lead to increased expression of FOSB. After induced by stretch or stress, up-regulated FOSB could participate in the mechano-transduction of uterine fibroids (31). This mechano-transduction may facilitate fibrosis, cause enhancive collagen 1A deposition, and attenuated fibronectin deposition.…”

Impact of Contraception on Uterine Fibroids

“…Moreover, UPA down regulates the expression of angiogenic growth factors, such as vascular endothelial growth factor (VEGF) and their receptors. Thus, it suppresses neo-vascularization, cell proliferation and survival in leiomyoma cells but not in normal myometrial cells [ 33 ]. Earlier studies in fibroid research demonstrated that cultured leiomyoma cells responded to 100 ng/mL of UPA (also known as CDB-2914; CDB-2914 (17α-acetoxy-11β-[4- N , N -dimethylaminophenyl]-19-norpregna-4,9-diene-3,20-dione) by regulating progesterone receptor (PR) isoforms [ 34 ].…”

Effect of ulipristal acetate on leomyoma of uterus

“…Fibroid volume shrank by 21% in the 5 mg group and 12% in the 10 mg group but increased by 3% in the placebo group. 4 Uterine bleeding was controlled in 90% of patients receiving 5 mg of UPA, in 98% of those receiving 10 mg of UPA, and in 89% of those receiving leuprolide acetate. Median times to amenorrhea were 7 days for patients receiving 5 mg of UPA, 5 days for those receiving 10 mg of UPA, and 21 days for those receiving leuprolide acetate.…”

“…It keeps oestradiol levels at mid follicular phase range, theirby reducing the incidence of hot flushes and exerting no impact on bone turnover. 4 There are several study about UPA. In one study patients were randomised to receive UPA 5 mg/day (96 women) or UPA 10 mg/day (98 women) or placebo (48 women).…”