Uliginosin B, a natural phloroglucinol derivative with antidepressant-like activity, increases Na+,K+-ATPase activity in mice cerebral cortex

Stein, Ana Cristina; Müller, Liz Girardi; Ferreira, Andréa G. K.; Braga, Andressa; Betti, Andresa Heemann; Centurião, Fernanda Bossemeyer; Scherer, Emilene B. S.; Kolling, Janaína; Poser, Gilsane Lino von; Wyse, Ângela T. S.; Rates, Stela Maris Kuze

doi:10.1016/j.bjp.2016.04.005

Cited by 8 publications

(4 citation statements)

References 57 publications

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“…Phloroglucinol enhance the Na + K + ATPase activity than ISO treated group, which is might be due to the membrane stabilizing properties of phloroglucinol. Present study results are well corroborated with different investigation of phloroglucinol derivative in Na + K + ATPase activity (Stein et al, ).…”

Section: Discussionsupporting

confidence: 91%

Phloroglucinol averts isoprenaline hydrochloride induced myocardial infarction in rats

Zhu

Wang

et al. 2019

Drug Development Research

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Myocardial infarction (MI) is indicated by the symptoms like sharp chest pain, sweating, palpitations, and nervousness finally leading to heart attack. MI occurs mainly due to the risk factors like smoking, elevated blood pressure, diabetes, hypercholesterolemia, obesity, decreased HDL level, elevated LDL level, hyperlipoproteinemia and aging consequently leads to demandable coronary blood supply, oxidative stress, and acute necrosis of the myocardium. Cardioprotective potential of the phloroglucinol (PG) was assessed by treating isoprenaline hydrochloride (ISO; 85 mg/kg b.w., s.c.) induced MI model in rats. Pretreatment with PG in a dose of 30 mg/kg was done for 28 days and followed by ISO (for MI induction) on 29th and 30th days, exhibited decline in the abnormalities in the ECG patterns, cardiac marker enzymes, enzymic and nonenzymic antioxidants, lipid peroxidation, lipid profiles, and histopathological investigations compared to isoprenaline alone treated group. On the whole, the present investigations elucidate the significance of PG in alleviating the pathological process and appreciably prevent the induction of MI in experimental rats. K E Y W O R D SAST, HDL, isoprenaline, myocardial infarction, Phloroglucinol

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Section: Discussionsupporting

confidence: 91%

Phloroglucinol averts isoprenaline hydrochloride induced myocardial infarction in rats

Zhu

Wang

et al. 2019

Drug Development Research

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“…Dimeric acylphloroglucinols are found to exhibit a wide array of bioactivities. For example, uliginosin B (38) has analgesic and antidepressant effects, [35][36][37] and insecticidal effects against pathogenic protozoan Trichomonas vaginalis. 38 Uliginosin A (36) was found to have anti-inammatory potential.…”

Section: Phenolsmentioning

confidence: 99%

Methylene-bridged dimeric natural products involving one-carbon unit in biosynthesis

et al. 2022

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“…Most importantly, hypericin and pseudohypericin from H. perforatum have been considered as responsible for its anti-depressant activity [ 4 ]. Uliginosin B, a dimeric acylphloroglucinol from H. uliginosum and H. brasiliense , among the others, has shown antinociceptive [ 5 ] and antidepressant-like activities in mice [ 6 ], antiprotozoal activity against Trichomonas vaginalis [ 7 ] and antibacterial activity against Staphylococcus aureus and S. epidermidis [ 8 ]. Three prenylated phloroglucinols isolated from the leaves of H. scruglii from Sardinia (Italy) have been identified as novel dual HIV-1 inhibitors, and were able to inhibit the HIV-1 replication in cell-based assays [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

An Integrated LC-ESI-MSn and High Resolution LC-ESI-QTOF Approach for the Identification of Phloroglucinols from Nepalese Hypericum japonicum

et al. 2020

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Phloroglucinols are characteristic constituents of Hypericumjaponicum that are claimed to exert several bioactivities, such as anti-inflammatory, anti-depressant and anti-viral ones. Phloroglucinols are unstable compounds and their synthesis is challenging; thus, isolation from natural sources is still one of the main strategies for obtaining these constituents in purified form. Assessing the presence of phloroglucinols in plant materials can be of interest for compound isolation, and LC-MS approaches afford sensitivity and specificity in this regard. In this work, we combined data from quadrupole-time of flight (QTOF) and ion trap (IT) mass spectrometers in order to assess the presence of the phloroglucinols characteristic of H. japonicum and to elucidate their MS fragmentation pathways. The identified compounds present similar structures bearing the 1,3,5-trihydroxybenzene core with different substitutions, which, in constituents at higher MW, is linked to 3′,3′-dimethyl-6′-oxo-phlorisobutyrophenone by a methylene bridge. Differences in MS2 spectra of the considered phloroglucinols are useful for compound identification and differentiation, and to perform dereplication studies. Overall, the proposed approach could be useful for the analysis of phloroglucinols in H. japonicum and other plant species.

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Uliginosin B, a natural phloroglucinol derivative with antidepressant-like activity, increases Na+,K+-ATPase activity in mice cerebral cortex

Cited by 8 publications

References 57 publications

Phloroglucinol averts isoprenaline hydrochloride induced myocardial infarction in rats

Phloroglucinol averts isoprenaline hydrochloride induced myocardial infarction in rats

Methylene-bridged dimeric natural products involving one-carbon unit in biosynthesis

An Integrated LC-ESI-MSn and High Resolution LC-ESI-QTOF Approach for the Identification of Phloroglucinols from Nepalese Hypericum japonicum

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