Ulcerative colitis and irritable bowel syndrome: relationships with quality of life

Ansari, Reza; Attari, Fatemeh; Razjouyan, Hadi; Etemadi, Arash; Amjadi, Hiva; Merat, Shahin; Malekzadeh, Reza

doi:10.1097/meg.0b013e3282f16a62

Cited by 73 publications

(62 citation statements)

References 32 publications

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“…However, the reported studies had no control groups and were not consistent in the definition of inactive IBD or in the methods used for the diagnosis of IBS. [10][11][12][13] As a result, the true prevalence of IBS-like symptoms remained uncertain.…”

Section: Discussionmentioning

confidence: 99%

“…Those reports have included the following findings: 35.4% (11/31), 45.6% (42/92), 59.7% (37/62), and 57% (23/40) of CD patients; 38% (7/18), 46% (23/50), 38.6% (17/44), and 33% (14/43) of UC patients. [10][11][12][13] In healthy adults, the prevalence of IBS using the Rome III diagnostic questionnaire was reported to be approximately 10% to 15%. [23][24][25] The Rome III classification is based on the symptom-based diagnostic criteria which is not explained by pathologically and endoscopically based disorders.…”

Section: Discussionmentioning

confidence: 99%

“…17 Such symptoms are thought to occur in approximately 30% to 50% of patients with inactive IBD, a considerably higher prevalence than in healthy control subjects. [8][9][10][11][12][13][14][15][16] These findings are of considerable interest as we attempt to deepen our understanding of the inactive IBD disease state.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, most of these studies used the Rome II definition; only a few Rome III reports are available. 10,12,13 In Japan, the prevalence of IBS complications in IBD has not been investigated on a large scale, so little is known about whether such complications are actually common among Japanese patients, and risk factors that may predispose patients to IBS-like symptoms have not been addressed.…”

Section: Introductionmentioning

confidence: 99%

“…However, recent reports suggest that IBD can manifest IBS-like symptoms such as diarrhea and abdominal pain, even after bowel inflammation has been eliminated and the patient has entered clinical remission or mucosal lesions have healed. [8][9][10][11][12][13][14][15][16] This has been attributed to the persistence of microinflammation in the mucosa and to increased permeability of the gastrointestinal mucosa. 17 Such symptoms are thought to occur in approximately 30% to 50% of patients with inactive IBD, a considerably higher prevalence than in healthy control subjects.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Irritable Bowel Syndrome-like Symptoms in Japanese Patients with Inactive Inflammatory Bowel Disease

Tomita

Kato

Takimoto

et al. 2016

J Neurogastroenterol Motil

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Background/AimsFew studies are available that have investigated the risk factors for overlapping irritable bowel syndrome (IBS)-like symptoms in patients with inactive inflammatory bowel disease (IBD). The present study has 3 objectives: (1) to assess the prevalence of IBS-like symptoms in Japanese patients with inactive IBD using Rome III criteria, (2) to examine the relationship of IBS-like symptoms to health related quality of life (HR-QOL), and (3) to investigate associations for developing IBS-like symptoms in patients with inactive IBD. MethodsIBS-like symptoms were evaluated using the Rome III questionnaire for functional gastrointestinal disorders. HR-QOL and hospital anxiety and depression scale were evaluated. Results IBS-like symptoms were found in 17.5% (7/40) of patients with inactive ulcerative colitis, 27.1% (29/107) of patients with inactive Crohn's disease (CD), and 5.3% (23/438) of healthy control subjects. The QOL level was significantly lower and anxiety score was significantly higher in inactive CD patients with IBS-like symptoms than in those without such symptoms (P = 0.003, P = 0.009). Use of anti-anxiety drugs was associated with the presence of IBS symptoms (P = 0.045). HR-QOL score was lower and anxiety score was higher in patients with inactive ulcerative colitis, but the difference was not statistically significant. ConclusionsThe prevalence of IBS-like symptoms in inactive IBD patients was significantly higher than in healthy controls. Inactive CD patients with IBS-like symptoms has low QOL and anxiety; suggesting that anxiety may be associated with symptom development in such patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prevalence of Irritable Bowel Syndrome-like Symptoms in Japanese Patients with Inactive Inflammatory Bowel Disease

Tomita

Kato

Takimoto

et al. 2016

J Neurogastroenterol Motil

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Strategies to improve quality of life in adolescents with inflammatory bowel disease

Karwowski

Keljo

Szigethy

2009

Inflammatory Bowel Diseases

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Inflammatory bowel disease (IBD), which encompasses Crohn's disease (CD) and ulcerative colitis (UC), are chronic and debilitating conditions with unpredictable courses and complicated treatment. Pediatric IBD carries implications that extend beyond the health of the gastrointestinal tract. When these lifelong illnesses are diagnosed during adolescence, a critical developmental period, the transition to adulthood can be even more turbulent. Like other chronic diseases of childhood, patients with IBD are at risk for depression, anxiety, social isolation, and altered self-image, which can all negatively affect health-related quality of life (HRQOL). The review will draw from pertinent adult and pediatric literature about HRQOL over the past 10 years using a PubMed literature search to summarize instruments with which HRQOL is measured, and address factors that affect HRQOL in adolescents and young adults with IBD. Psychosocial interventions that have been utilized to improve quality of life in this population will also be covered. Identifying patients with impaired quality of life is of paramount importance, as is implementing strategies that may improve HRQOL, so that they may have an easier transition to adulthood while living with IBD.

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Bladder‐bowel interactions: Do we understand pelvic organ cross‐sensitization? International Consultation on Incontinence Research Society (ICI‐RS) 2018

Panicker

Marcelissen

Gontard

et al. 2019

Neurourology and Urodynamics

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Aims: Mounting evidence from experimental animal and human studies suggests that cross-sensitization exists between different organs. Lower urinary tract (LUT) and bowel dysfunction commonly overlap, and the role of crosssensitization between pelvic visceral organs is uncertain. Methods: At the International Consultation on Incontinence Research Society (ICI-RS) meeting in 2018, a panel of clinicians participated in a discussion on bladder and bowel interactions in the context of pelvic organ cross-sensitization.Results: Bladder and bowel problems commonly co-occur in adults and children across different disorders, and the mechanism responsible for overlapping dysfunction is uncertain in most instances. At a neuronal level, cross-sensitization occurs as a result of afferent signaling from the LUT and lower bowel through different central and peripheral mechanisms. Studies in animals and humans have demonstrated evidence for cross-organ sensitization following experimental inflammation or distension of the lower bowel, affecting the LUT. Nerve stimulation is an effective treatment for different functional LUT and bowel disorders, and whether this treatment may influence crossorgan sensitization remains uncertain. The role of physiologically dormant C-fibers, the bladder-gut-brain axis, and gut microbiome in cross-sensitization are speculative. Conclusion: Recommendations for research were made to explore the role of cross-organ sensitization in the pathogenesis of co-occurring LUT and bowel dysfunction in humans. K E Y W O R D Sbladder pain syndrome, constipation, cross-organ, cross-talk, irritable bowel syndrome, microbiome, psychology, sensitization F I G U R E 1 Inter-relationship between disorders of the lower urinary tract and bowel. LUTS, lower urinary tract symptoms S26 |

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Ulcerative colitis and irritable bowel syndrome: relationships with quality of life

Abstract: The prevalence of IBS-like symptoms in UC patients in remission is about three times higher than in controls, and these patients have impaired HRQOL comparable with that of UC patients in the active phase.

Cited by 73 publications

References 32 publications

Prevalence of Irritable Bowel Syndrome-like Symptoms in Japanese Patients with Inactive Inflammatory Bowel Disease

Prevalence of Irritable Bowel Syndrome-like Symptoms in Japanese Patients with Inactive Inflammatory Bowel Disease

Strategies to improve quality of life in adolescents with inflammatory bowel disease

Bladder‐bowel interactions: Do we understand pelvic organ cross‐sensitization? International Consultation on Incontinence Research Society (ICI‐RS) 2018

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