1998
DOI: 10.1080/109158198226765 View full text |Buy / Rent full text
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Abstract: D ep a r t m en t of P a t h ology, D a lh ou s ie U n ive r s it y, I W K G r a ce H ea lt h C e n t r e , H a lifa x, N ov a S cot ia , C a n a d a S . A . H i n ch lif feD e p a r t m e n t of P a t h olog y, U n iver s it y of N e w ca s t le -u p on -Tyn e , N e w ca s t le -u p on -Tyn e , U n it e d K in g d om J . D . P op e M R C R es ea r ch C e n t r e , U n ive r s it y of O xfor d , O xfor d , U n it ed K in gd om L . M . B a ll a n d D . Va n Vel z enD ep a r t m en t of P a t h ology, D a lh ou … Show more

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“…It is important to note that the intake of Eudragit by children with FC in the UK ranged from 100± 250 mg/kg/day and up to a total of 2500 mg/day, thus far exceeding the recommended safe exposure limit for adults. 18 Because the surface area of the colon relative to body weight is several times smaller in children than in adults, the colonic exposure levels were even higher in children than the intake in mg/kg/day would suggest. 19 Following reports of FC, van Velzen and coworkers carried out a new evaluation of the eects of Eudragit in rat and pig models.…”
Section: In Model 3 Of Theirmentioning
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“…It is important to note that the intake of Eudragit by children with FC in the UK ranged from 100± 250 mg/kg/day and up to a total of 2500 mg/day, thus far exceeding the recommended safe exposure limit for adults. 18 Because the surface area of the colon relative to body weight is several times smaller in children than in adults, the colonic exposure levels were even higher in children than the intake in mg/kg/day would suggest. 19 Following reports of FC, van Velzen and coworkers carried out a new evaluation of the eects of Eudragit in rat and pig models.…”
Section: In Model 3 Of Theirmentioning
“…22 Lannon et al suggest that the surfactants may facilitate transmucosal transport of the polymer component of enteric coating. 18 Once in contact with the submucosa, the polymer may act as a ®brogenic agent. Polymethylmethacrylate, a polymer used as a cement for hip prostheses, is known to enhance human ®broblast proliferation in vitro and is thought to be responsible for the ®brosis and scar formation which develops between the cement and bone in vivo.…”
Section: In Model 3 Of Theirmentioning