Uji Aktivitas Anti-Inflamasi Minyak Atsiri Daun Kemangi (Ocimum americanum L.) pada Tikus Putih Jantan yang Diinduksi Karagenan

Saputri, Fadlina Chany; Zahara, Rita

doi:10.7454/psr.v3i3.3619

Cited by 16 publications

(12 citation statements)

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“…Manufacture of CMC-Na 0.5% solution CMC-Na 0.5% solution was made accordingly the method of Salma et al(2013) 35 , and the dosage was defined by the references of Saputri & Zahara (2016). 36 A total of 0.5 g CMC-Na (Sigma-Aldrich) was poured into a beaker glass and dissolved in ±30 ml warm aquades, then was homogenously unified. CMC-Na solution was then moved to a 100 ml volumetric flask till reached the threshold and stirred up until homogenous.…”

Section: Extractionmentioning

confidence: 99%

Anti-diabetic Activity of the Red Dragon Fruit Peel (Hylocereus polyrhizus) in Ethanol Extract against Diabetic Rats

Panjaitan¹,

Novitasari²

2021

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Background:The red dragon fruit peel, which is rarely used in general, contains higher antioxidant properties compared to the flesh parts and has various secondary metabolites utilised in medicines. Objectives: This study was aimed to determine the effects of ethanol extract administration of the red dragon fruit peel (Hylocereus polyrhizus) against the decline of blood glucose levels in diabetes mellitus rats. Methods: In this study, the total of 24 male white Wistar rats (Rattus novergicus) were divided into 4 groups. All experimental animals were induced to diabetic conditions by the administration of streptozotocin and nicotinamide dosages at 45 mg/kg body weight and 110 mg/kg body weight, respectively. For 14 days, each group was treated accordingly. The first group or negative control (NC) was treated with the administration of CMC-Na 0.5% dose 2 ml/200 g body weight; the second group or positive control (PC) was administrated with glibenclamide dose 0.09 mg/200 g body weight; the third (E1) and fourth (E2) groups were administered with the ethanol extracts of the red dragon fruit peels at dosages of 37.44 mg/200 g body weight and 74.88 mg/200 g body weight, respectively. Results: After the 14-day trial, the average levels of blood glucose on the negative control group (382.92 mg/dl) experienced no decline, and the blood glucose levels amongst groups were statistically different (p<0.05). Conclusion:The anti-diabetic activity of the red dragon fruit peel in the ethanol extract dose 74.88 mg/200 g body weight is statistically equal to the glibenclamide dose 0.09 mg/200 g body weight.

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Section: Extractionmentioning

confidence: 99%

Anti-diabetic Activity of the Red Dragon Fruit Peel (Hylocereus polyrhizus) in Ethanol Extract against Diabetic Rats

Panjaitan¹,

Novitasari²

2021

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“…Selain itu pengindentifikasian daun kemangi menggunakan metode GC/MS terdapat kandungan seperti seperti 3,7-dimetil-1,6-oktadien-3-ol (linalool 3,94 mg/g), 1-metoksi-4-(2-propenil) benzena (estragol 2,03 mg/g), metil sinamat (1,28 mg/g), 4-alil-2-metoksifenol (eugenol 0,896 mg/g), dan 1,8-sineol (0,288mg/g). 11,12 Minyak atsiri pada daun kemangi memberikan aroma yang khas. Minyak atsiri daun kemangi diketahui mengandung sitral, kamfer dan metil sinamat.…”

Section: Metodeunclassified

<p>Pengaruh ekstrak daun kemangi (Ocimum basilicum L) terhadap Staphylococcus aureus di rongga mulut</p><p>Effect of basil leaf extract (Ocimum basilicum L.) on oral Staphylococcus aureus</p>

et al. 2021

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Pendahuluan: Staphylococcus aureus merupakan mikroorganisme dalam rongga mulut yang bersifat patogen. Di Indonesia, penyakit infeksi masih menjadi masalah umum terutama pada rongga mulut, untuk itu dikembangkan obat antibakteri yang berasal dari tumbuhan salah satunya daun kemangi. Tujuan penelitian untuk menganalisis efektivitas penggunaan ekstrak daun kemangi (Ocimum basilicum L) terhadap jumlah Staphylococcus aureus rongga mulut. Metode: Penelitian ini menggunakan true eksperiment laboratoris, dimana pengujian efektivitas antibakteri dengan metode pengenceran seri. Sampel yang digunakan strain murni Staphylococcus aureus dan isolat klinik Staphylococcus aureus. Konsentrasi ekstrak yang digunakan 50%, 25%, 12,5%, 6,25% dan dilakukan pengulangan sebanyak 4 kali. Data penelitian diolah menggunakan SPSS yaitu uji Kruskal-Wallis dan uji Mann-Whitney.Hasil: Konsentrasi 50% merupakan kadar bunuh minimum (KBM) untuk strain murni bakteri Staphylococcus aureus, dan kadar hambat minimum (KHM) untuk isolat klinik Staphylococcus aureus. Konsentrasi 25% hanya didapati kadar hambat minimum (KHM) untuk strain murni Staphylococcus aureus. Simpulan: Terdapat pengaruh penggunaan ekstrak daun kemangi (Ocimum basilicum L) terhadap penurunan jumlah Staphylococcus aureus rongga mulut.Kata kunci : Daun kemangi, Staphylococcus aureus, pengenceran seri, KHM, KBM. ABSTRACTIntroduction: Staphylococcus aureus is a pathogenic microorganism in the oral cavity. In Indonesia, infectious diseases are still a common problem, especially in the oral cavity. Therefore, a natural antibacterial remedy has been developed, one of which is basil leaves. The study aimed to analyse the effectiveness of using basil leaf extract (Ocimum basilicum L) against the number of oral Staphylococcus aureus. Methods: This study used a true laboratory experiment, where the antibacterial effectiveness was tested by using the series dilution method. The samples used were pure strains of Staphylococcus aureus and clinical isolates of Staphylococcus aureus. The extract concentration used was 50%, 25%, 12.5%, 6.25% and was repeated 4 times. The research data were processed using SPSS, namely the Kruskal-Wallis test and the Mann-Whitney test. Results: The concentration of 50% is the minimum kill rate (MKC) for pure strains of Staphylococcus aureus and the minimum inhibitory level (MIC) for clinical isolates of Staphylococcus aureus. At 25% concentration, only the minimum inhibitory level (MIC) was found for pure strains of Staphylococcus aureus. Conclusion: There is an effect of using basil leaf extract (Ocimum basilicum L) on reducing the number of oral Staphylococcus aureus.Keywords: Basil leaf, Staphylococcus aureus, serial dilution, MIC, MKC.

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“…Pada induksi dengan karagenan 1% sebanyak 0,2 mL mulai tebentuk pada jam pertama dan mencapai maksimalnya pada jam ke tiga. Sedangkan 2% dengan pemberian 0,2 mL, udem maksimal terjadi pada jam kelima (Saputri & Zahara, 2016). Untuk penelitian ini dipilih karagenan 1% karena udem maksimum yang terbentuk relatif lebih cepat.…”

Section: Hasil Dan Pembahasanunclassified

Aktivitas Anti Inflamasi dan Penyembuhan Luka dari Ekstrak Kulit Batang Murbei (Morus alba L.)

Lallo

Hardianti

Umar

et al. 2020

JFG

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Mulberry (Morus alba L.) leaf has been used as a traditional medicine for treatment of some tropical diseases and also popular using for silkworm feed. On this research, anti-inflammatory and wound healing activities of the bark extract has been investigated in vivo. The bark was extracted with three organic solvent in a different polarity to carry out a group compounds in n-hexane extract (EH), Eto-Ac extract (EE), and EtOH extract (EO). Anti-inflammatory was investigated on inflammatory mice induced by 1% carrageenan. Among the extract (200mg/kg BW), EE showed strongly decrease inflammation by 42% than the other extract and stronger than the positive control, Na-diclofenac. Further investigation on healing effect of wound and burn injury which was tested at concentration of 1% topically to each extract. All the extract significantly showed healing activity, among them EE was observed as the stronger one while slightly less than the positive control. This result indicated that the most active compounds on anti-inflammatory and healing wounded was extracted with ethyl acetate that could be used for drug discovery.

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Uji Aktivitas Anti-Inflamasi Minyak Atsiri Daun Kemangi (Ocimum americanum L.) pada Tikus Putih Jantan yang Diinduksi Karagenan

Cited by 16 publications

References 0 publications

Anti-diabetic Activity of the Red Dragon Fruit Peel (Hylocereus polyrhizus) in Ethanol Extract against Diabetic Rats

Anti-diabetic Activity of the Red Dragon Fruit Peel (Hylocereus polyrhizus) in Ethanol Extract against Diabetic Rats

<p>Pengaruh ekstrak daun kemangi (Ocimum basilicum L) terhadap Staphylococcus aureus di rongga mulut</p><p>Effect of basil leaf extract (Ocimum basilicum L.) on oral Staphylococcus aureus</p>

Aktivitas Anti Inflamasi dan Penyembuhan Luka dari Ekstrak Kulit Batang Murbei (Morus alba L.)

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