Udp Glucuronyltransferase and Phenolsulfotransferase From Rat Liver in Vitro

Mulder, Gerard J.; Doorn, A.B.D. van

doi:10.1016/b978-0-08-021308-8.50309-4

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1978

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“…This in not surprising since the molecule has two free phenolic hydroxyl groups available for conjugation. Glucuronic acid conjugation accounts for 44% of the dose and sulphate 17%, which is to be expected since larger phenols are more readily conjugated with glucuronic acid than with sulphate (see Mulder,6). It is of interest that two glucuronides are formed, which must be the mono-and di-glucuronides, since the molecule is symmetrical and the two hydroxyl groups are equivalent.…”

Section: Discussionmentioning

confidence: 99%

The fate of dichlorophen in the rat

Dixon

Caldwell

1978

European Journal of Drug Metabolism and Pharmacokinetics

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The fate of [l4C] dichlorophen (2,2'-dihydroxy-5,5'-dichlorodiphenyl [l4C]methane) has been studied in the rat. The compound was well absorbed after oral examination, with 78% of the dose excreted in the urine and 15% in the faeces in 2 days. The metabolism of dichlorophen involves both sulphate and glucuronic acid conjugation, and a small amount of unchanged drug is excreted. Studies in bile duct-cannulated rats indicated the occurrence of an extensive enterohepatic circulation of dichlorophen monoglucuronide.

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Section: Discussionmentioning

confidence: 99%