UCP1 and oxidative capacity of adipose tissue in adult ferrets (Mustela putorius furo)

Fuster, Antònia; Oliver, Paula; Sánchez, Juana; Picó, Catalina

doi:10.1016/j.cbpa.2009.01.007

Cited by 25 publications

(36 citation statements)

References 39 publications

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“…In suckling rats, a threefold excess vitamin A intake as RE affects early adipose tissue development and conditions future fat expansion in response to an obesogenic diet . Moreover, several studies provided evidence that dietary BC can impact adipose tissue in adult animals including rodents and ferrets . These findings prompted us to compare the effects of dietary RE and BC supplementation during the suckling period on adipose tissue development in young rats.…”

Section: Discussionmentioning

confidence: 99%

β‐Carotene during the suckling period is absorbed intact and induces retinoic acid dependent responses similar to preformed vitamin A in intestine and liver, but not adipose tissue of young rats

Mušinović

Bonet

Granados

et al. 2014

Molecular Nutrition Food Res

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Section: Discussionmentioning

confidence: 99%

β‐Carotene during the suckling period is absorbed intact and induces retinoic acid dependent responses similar to preformed vitamin A in intestine and liver, but not adipose tissue of young rats

Mušinović

Bonet

Granados

et al. 2014

Molecular Nutrition Food Res

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“…During murine postnatal development, these brite cells spontaneously emerge around weaning (Xue et al 2007;Lasar et al 2013). A similar phenomenon has also been observed in neonates from several other mammalian species such as the dog (Canis lupus familiaris L., 1758) (Ashwell et al 1987), semi-domesticated reindeer (Rangifer tarandus tarandus L., 1758) (Soppela et al 1991), and goat (Capra hircus L., 1758) (Trayhurn et al 1993), as well as coldacclimated rat (Rattus norvegicus Berkenhout, 1769) (Cousin et al 1992), cat (Felis catus L., 1758) (Loncar et al 1986), and ferret (Mustela putorius furo L., 1758) (Fuster et al 2009). Recently, it has been suggested that brite cells represent a new class of adipocytes distinct from white and brown adipocytes with respect to their development, molecular outfit, and hormonal sensitivity (Petrovic et al 2010;Wu et al 2012).…”

Section: Introduction On Brown Fat Biologymentioning

confidence: 97%

White, brite, and brown adipocytes: the evolution and function of a heater organ in mammals

et al. 2014

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Brown fat is a specialized heater organ in eutherian mammals. In contrast to the energy storage function of white adipocytes, brown adipocytes dissipate nutrient energy by uncoupling of mitochondrial oxidative phosphorylation, which depends on uncoupling protein 1 (UCP1). UCP1, as well as UCP2 and UCP3, belong to the family of mitochondrial carriers inserted into the inner mitochondrial membrane for metabolite trafficking between the matrix and the intermembrane space. UCP1 transports protons into the mitochondrial matrix when activated by a rise in free fatty acid levels in the cell. This UCP1-dependant proton leak drives high oxygen consumption rates in the absence of ATP synthesis and dissipates proton motive force as heat. The enormous heating capacity of brown fat is supported by dense vascularization, high rates of tissue perfusion, and high mitochondrial density in brown adipocytes.It has been known for more than 50 years that nonshivering thermogenesis in brown fat serves to maintain body temperature of neonates and small mammals in cold environments, and is used by hibernators for arousal from torpor. It has been speculated that the development of brown fat as a new source for nonshivering thermogenesis provided mammals with a unique advantage for survival in the cold. Indeed brown fat and UCP1 is found in ancient groups of mammals, like the afrotherians and marsupials. In the latter, however, the thermogenic function of UCP1 and brown fat has not been demonstrated as of yet. Notably, orthologs of all three mammalian UCP genes are also present in the genomes of bony fishes and in amphibians. Molecular phylogeny reveals a striking increase in the substitution rate of UCP1 between marsupial and eutherian lineages. At present, it seems that UCP1 only gained thermogenic function in brown adipocytes of eutherian mammals, whereas the function of UCP1 and that of the other UCPs in ectotherms remains to be identified.Evolution of thermogenic function required expression of UCP1 in a brown-adipocyte-like cell equipped with high mitochondrial density embedded in a well-vascularized tissue. Brown-adipocyte-like cells in white adipose tissue, called "brite" (brownin-white) or "beige" adipocytes, emerge during adipogenesis and in response to cold exposure in anatomically distinct adipose tissue depots of juvenile and adult rodents. These brite adipocytes may resemble the archetypical brown adipocyte in vertebrate evolution. It is therefore of interest to elucidate the molecular mechanisms of brite adipocyte differentiation, study the bioenergetic properties of these cells, and search for the presence of related brown-adipocyte-like cells in nonmammalian vertebrates.Résumé : Le tissu adipeux brun est un organe de production de chaleur spécialisé chez les mammifères euthériens. Contrairement aux adipocytes blancs, qui ont une fonction de stockage d'énergie, les adipocytes bruns dissipent l'énergie des aliments nutritifs en découplant la phosphorylation oxydative mitochondriale, un processus qui dépend de la protéine de...

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“…However, conflicting results recently have been obtained in ferrets in which mechanisms apparently distinctive to vitamin A may operate, possibly related to the fact that this animal model has a limited intestinal cleavage of b-carotene compared with rodents (53). On the other hand, b-carotene-monooxygenase-1 (BCMO1) 12 activity has been found in many mammalian tissues, including adipose tissue.…”

Section: Introductionmentioning

confidence: 98%

β-Carotene Is an Important Vitamin A Source for Humans

Grune

Lietz

Palou

et al. 2010

The Journal of Nutrition

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257

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Experts in the field of carotenoids met at the Hohenheim consensus conference in July 2009 to elucidate the current status of β-carotene research and to summarize the current knowledge with respect to the chemical properties, physiological function, and intake of β-carotene. The experts discussed 17 questions and reached an agreement formulated in a consensus answer in each case. These consensus answers are based on published valid data, which were carefully reviewed by the individual experts and are justified here by background statements. Ascertaining the impact of β-carotene on the total dietary intake of vitamin A is complicated, because the efficiency of conversion of β-carotene to retinol is not a single ratio and different conversion factors have been used in various surveys and following governmental recommendations within different countries. However, a role of β-carotene in fulfilling the recommended intake for vitamin A is apparent from a variety of studies. Thus, besides elucidating the various functions, distribution, and uptake of β-carotene, the consensus conference placed special emphasis on the provitamin A function of β-carotene and the role of β-carotene in the realization of the required/recommended total vitamin A intake in both developed and developing countries. There was consensus that β-carotene is a safe source of vitamin A and that the provitamin A function of β-carotene contributes to vitamin A intake.

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UCP1 and oxidative capacity of adipose tissue in adult ferrets (Mustela putorius furo)

Cited by 25 publications

References 39 publications

β‐Carotene during the suckling period is absorbed intact and induces retinoic acid dependent responses similar to preformed vitamin A in intestine and liver, but not adipose tissue of young rats

β‐Carotene during the suckling period is absorbed intact and induces retinoic acid dependent responses similar to preformed vitamin A in intestine and liver, but not adipose tissue of young rats

White, brite, and brown adipocytes: the evolution and function of a heater organ in mammals

β-Carotene Is an Important Vitamin A Source for Humans

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