2018
DOI: 10.18632/aging.101587
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Has erratum 2019-5-31
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Abstract: Invasion and metastasis are the main cause of recurrence and death in advanced hepatocellular carcinoma (HCC). Revealing the mechanisms of HCC metastasis is important for developing new therapeutic approaches and reducing patient mortality. Ubiquitin specific protease 4 (USP4), is involved in tumorigenesis by deubiquitinating some important oncogenic proteins and impacting their degradation. In the present study, we found that USP4 was significantly upregulated in HCC tumor tissues and the high expression of U… Show more

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Cited by 23 publications
(20 citation statements)
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References 39 publications
(43 reference statements)
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“…The present study indicated that USP4 is a direct target of miR-513a-5p. It has been previously confirmed that USP4 could act as a tumor promoter in liver cancer (34). These results further confirm the role of USP4 during the development of liver cancer.…”
Section: Discussionsupporting
confidence: 79%
“…The present study indicated that USP4 is a direct target of miR-513a-5p. It has been previously confirmed that USP4 could act as a tumor promoter in liver cancer (34). These results further confirm the role of USP4 during the development of liver cancer.…”
Section: Discussionsupporting
confidence: 79%
“…Our findings firstly indicated that USP4 is a direct target of miR-513a-5p. It has been previously confirmed that USP4 could act as a tumor promoter in liver cancer (34). These results further implicate USP4 in the development of liver cancer; indeed, it suggests USP4 a key promoter in the occurrence of liver cancer.…”
Section: Discussionsupporting
confidence: 60%
“…Our ndings rstly indicated that USP4 is a direct target of miR-513a-5p. It has been previously con rmed that USP4 could act as a tumor promoter in liver cancer (34). These results further implicate USP4 in the development of liver cancer; indeed, it suggests USP4 a key promoter in the occurrence of liver cancer.…”
Section: Discussionsupporting
confidence: 53%