volume 10, issue 10, P2783-2799 2018
DOI: 10.18632/aging.101587
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Chan Qiu, Yan Liu, Ying Mei, Min Zou, Zhibo Zhao, Mingxin Ye, Xiaoling Wu

Abstract: Invasion and metastasis are the main cause of recurrence and death in advanced hepatocellular carcinoma (HCC). Revealing the mechanisms of HCC metastasis is important for developing new therapeutic approaches and reducing patient mortality. Ubiquitin specific protease 4 (USP4), is involved in tumorigenesis by deubiquitinating some important oncogenic proteins and impacting their degradation. In the present study, we found that USP4 was significantly upregulated in HCC tumor tissues and the high expression of U…

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