Über das Formisobutyraldol (X. Mitteil. über Derivate des Aldols und des Crotonaldehyds)

Späth, Ernst; Szilágyi, I

doi:10.1002/cber.19430760924

Cited by 11 publications

(3 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The samples were obtained from reaction mixtures of FA with different aliphatic aldehydes that produced β-hydroxyaldehydes. The DNPH derivatization of DHPAL has been used earlier for elemental analysis for compound identification and for polarographic analysis, but no applications for HPLC are known to us. No references were found in the literature either concerning derivatization or HPLC analysis of β-hydroxyaldehydes BHBAL and 2,2-bis(hydroxymethyl)propionaldehyde (BHPAL) as their DNPH derivatives.…”

mentioning

confidence: 99%

Quantitative RP-HPLC Determination of Some Aldehydes and Hydroxyaldehydes as Their 2,4-Dinitrophenylhydrazone Derivatives

1998

View full text Add to dashboard Cite

A high-performance liquid chromatographic (HPLC) method is described for the quantitative determination of some aliphatic aldehydes and β-hydroxyaldehydes as their 2,4-dinitrophenylhydrazone derivatives. A method is described for the preparation of derivatives for those β-hydroxyaldehydes where no reference compounds of known purity are available. The detection limit of the method was 4.3-21.0 μg/L, depending on the aldehyde.

show abstract

mentioning

confidence: 99%

Quantitative RP-HPLC Determination of Some Aldehydes and Hydroxyaldehydes as Their 2,4-Dinitrophenylhydrazone Derivatives

1998

View full text Add to dashboard Cite

show abstract

“…The Tishchenko reaction of 1,3-dioxan-4-ols has been reported typically for dimeric aldol products . Mixed dimers from a β -hydroxyaldehyde and a second aldehyde have been suspected for instability, but detailed investigations on their esterification have not been reported . Very little is known about the effects of different substituents on the formation, stability, stereochemistry, and reactivity of dioxanols similar to 8 .…”

Section: Resultsmentioning

confidence: 99%

Selective Mixed Tishchenko Reaction via Substituted 1,3-Dioxan-4-ols

Törmäkangas

Saarenketo

Koskinen

2002

Org. Process Res. Dev.

View full text Add to dashboard Cite

Monoesters of 1,3-diols can be prepared with the mixed Tishchenko reaction from -hydroxy aldehydes and another aldehyde. These two aldehydes form a diastereomeric mixture of 1,3-dioxan-4-ol hemiacetal derivatives which can be further converted to monoesters with suitable catalysts. Limitations in the formation and esterification of this hemiacetal intermediate have been investigated in this work and the formation and stability of 1,3-dioxan-4-ols was found to be aldehyde-, temperature-, and solvent-dependent. A new method was developed for selective preparation of monoesters of 1,3-diols with this mixed Tishchenko reaction via 1,3-dioxan-4-ols without any significant side products. During the development of this method a possibility to scale up the reactions to reach a selective and economical process was one of the main targets in this work.

show abstract

“…Hydroxypivalaldehyde (1a), exists as an equilibrium (Scheme 1) [13] between the dimer and the monomer with the exposed aldehyde functionality for HCN addition. Heating at 65 8C in THF [14] or without solvent at elevated temperatures (!…”

Section: The (R)-selective Hydroxya C H T U N G T R E N N U N G Nitrimentioning

confidence: 99%

Efficient Biocatalytic Synthesis of (R)‐Pantolactone

et al. 2008

View full text Add to dashboard Cite

Screening for stereoselective cyanohydrin synthesis in 96-well plates was employed in the development of an efficient, pH-stable hydroxynitrile lyase for the conversion of sterically hindered aliphatic aldehydes. Site-saturation mutagenesis (SSM) resulted in a powerful catalyst for the stereoselective conversion of hydroxypivalaldehyde and pivalaldehyde to their corresponding (R)-cyanohydrins (ee > 97%) which are used as chiral building blocks (e.g., for pantothenic acid production). Furthermore, redesigning the PaHNL5 gene and improving its expression by Pichia pastoris with the help of a new P AOX1 promoter variant and the helper protein PDI (protein disulfide isomerase) led to elevated amounts of todays most efficient biocatalyst for vitamin B 5 synthesis.

show abstract

Über das Formisobutyraldol (X. Mitteil. über Derivate des Aldols und des Crotonaldehyds)

Cited by 11 publications

References 3 publications

Quantitative RP-HPLC Determination of Some Aldehydes and Hydroxyaldehydes as Their 2,4-Dinitrophenylhydrazone Derivatives

Quantitative RP-HPLC Determination of Some Aldehydes and Hydroxyaldehydes as Their 2,4-Dinitrophenylhydrazone Derivatives

Selective Mixed Tishchenko Reaction via Substituted 1,3-Dioxan-4-ols

Efficient Biocatalytic Synthesis of (R)‐Pantolactone

Contact Info

Product

Resources

About