Typhlitis: A Complication of Leukemia in Childhood

Wagner, Milton L.; Rosenberg, Harvey S.; Fernbach, Donald J.; Singleton, Edward B.

doi:10.2214/ajr.109.2.341

Cited by 159 publications

(73 citation statements)

References 5 publications

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“…33 Our result of 3.5% was much lower than the incidences reported in children with leukemia. 41,42 All cases were confirmed by radiological findings. In this study other cases of suspected typhilitis may have occurred but were not documented due to lack of supporting radiological data.…”

Section: Discussionmentioning

confidence: 68%

GI complications in pediatric patients post-BMT

Barker

Anderson

Sauvé

et al. 2005

Bone Marrow Transplant

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Summary:This retrospective study comprehensively examined hepatic and gastrointestinal complications post-bone marrow transplant (BMT) in a heterogeneous group of 132 pediatric patients that underwent 142 transplants. Hyperbilirubinemia occurred in 28% of this population with clinically evident jaundice in 16%. Acute graft-versus-host disease (GVHD) occurred in 46% of the population, with liver involvement in 39% and intestinal involvement in 60% of those with acute GVHD. Veno-occlusive disease (VOD) occurred in 18% of the population. A greater increase in hepatic transaminases was noted in GVHD and VOD than nonspecific liver injury. Serum bilirubin may help to differentiate between VOD and hepatic GVHD. Biliary sludging occurred in 20% of patients and was associated with increased morbidity. Common post transplant gastrointestinal complications included mucositis in 90%, vomiting in 85% and abdominal pain in 71%. TPN support post transplant was required in 91%. Diarrhea occurred in 67% with the most common identified etiologies reported as GVHD (27%), viral (6%), Clostridium difficile (8%) infections and unknown (28%). Typhilitis developed in 3.5%. Melena or hematochezia occurred in 11 patients (8%). However, gastrointestinal bleeding was disproportionately represented in intensive care unit admissions (5/27) and 100 day mortality (5/21). Gastrointestinal and hepatic complications represent a major cause of morbidity and mortality in pediatric BMT recipients.

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Section: Discussionmentioning

confidence: 68%

GI complications in pediatric patients post-BMT

Barker

Anderson

Sauvé

et al. 2005

Bone Marrow Transplant

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“…Alt et al 7 comunicaron en 1985 una mortalidad aproximada del 57% en pacientes sintomáticos con diagnóstico confirmado de enterocolitis necrosante. Dentro de los pacientes descritos en este estudio la mortalidad fue del 37%, menor a la recogida en la literatura médica, debido probablemente a la buena respuesta terapéutica obtenida con el tratamiento médico, lo que resalta las cualidades de este tipo de manejo 15 ; sin embargo, otros autores reseñan índices de sobrevida mayores al 55% en pacientes tratados quirúrgicamente 16 . En este estudio ninguno de los sujetos llevados a cirugía sobrevivió, debido al deterioro clínico de este grupo de pacientes en el momento de la intervención quirúrgica.…”

Section: Discussionunclassified

“…En algunas series de autopsias realizadas en pacientes con leucemia aguda se han encontrado entre un 10 y 12% de cambios histológicos indicativos de enterocolitis neutropénica; sin embargo, sólo el 3% de los sujetos de la gran mayoría de las series se presentan con síntomas graves que requieren exploración quirúrgica 16,17 . Estas observaciones sugieren que las indicaciones para un procedimiento quirúrgico de urgencia se limitan a la presencia de necrosis, perforación, irritación peritoneal o deterioro clínico a pesar del tratamiento médico.…”

Section: Discussionunclassified

Características clínicas y microbiológicas de la colitis neutropénica en adultos con neoplasias hematológicas del Instituto Nacional de Cancerología de Bogotá D.C. (Colombia)

Zorrilla

Combariza²,

Revéiz³

et al. 2004

Enferm Infecc Microbiol Clin

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“…Neutropenic enterocolitis (NE) was first described in 1970s as a complication of childhood leukemia treatment [1]. It is a life-threatening complication of chemotherapy, which can lead to death in immunocompromised patients.…”

Section: Introductionmentioning

confidence: 99%