Type-2 muscle fiber atrophy is associated with sarcopenia in elderly men with hip fracture

Tanganelli, Fabiana; Meinke, Peter; Hofmeister, Fabian; Jarmusch, Stefanie; Baber, Lisa; Mehaffey, Stefan; Hintze, Stefan; Ferrari, Uta; Neuerburg, Carl; Kammerlander, Christian; Schöser, Benedikt; Drey, Michael

doi:10.1016/j.exger.2020.111171

Cited by 24 publications

(16 citation statements)

References 43 publications

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“…Sarcopenia and aging have been associated with the preferential atrophy of fast-twitch fibers and a glycolytic-to-oxidative metabolic shift [ 39 , 66 ]. In two recent studies conducted on older adults, individuals presenting with a hip fracture also showed extensive Type II (fast-twitch) muscle fiber atrophy [ 67 , 68 ]. Whilst glycolytic muscle fibers are responsible for rapid muscle force production during muscle contraction and therefore have an essential role in facilitating strength, they also fatigue quicker as their glycogen storage depletes during glycolysis.…”

Section: Resultsmentioning

confidence: 99%

Gene Ontology (GO)-Driven Inference of Candidate Proteomic Markers Associated with Muscle Atrophy Conditions

et al. 2022

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Skeletal muscle homeostasis is essential for the maintenance of a healthy and active lifestyle. Imbalance in muscle homeostasis has significant consequences such as atrophy, loss of muscle mass, and progressive loss of functions. Aging-related muscle wasting, sarcopenia, and atrophy as a consequence of disease, such as cachexia, reduce the quality of life, increase morbidity and result in an overall poor prognosis. Investigating the muscle proteome related to muscle atrophy diseases has a great potential for diagnostic medicine to identify (i) potential protein biomarkers, and (ii) biological processes and functions common or unique to muscle wasting, cachexia, sarcopenia, and aging alone. We conducted a meta-analysis using gene ontology (GO) analysis of 24 human proteomic studies using tissue samples (skeletal muscle and adipose biopsies) and/or biofluids (serum, plasma, urine). Whilst there were few similarities in protein directionality across studies, biological processes common to conditions were identified. Here we demonstrate that the GO analysis of published human proteomics data can identify processes not revealed by single studies. We recommend the integration of proteomics data from tissue samples and biofluids to yield a comprehensive overview of the human skeletal muscle proteome. This will facilitate the identification of biomarkers and potential pathways of muscle-wasting conditions for use in clinics.

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Section: Resultsmentioning

confidence: 99%

Gene Ontology (GO)-Driven Inference of Candidate Proteomic Markers Associated with Muscle Atrophy Conditions

et al. 2022

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“…Notably, muscle atrophy caused by aging occurs in type II fiber [ 26 ]. In our data, amelioration of muscle weight reduction by TE supplementation was observed in the tibialis anterior and extensor digitorum longus muscles in DEX-treated mice.…”

Section: Discussionmentioning

confidence: 99%

Suppressive Effects of Turmeric Extract on Muscle Atrophy in Dexamethasone-Treated Mice and Myotubes

Furukawa¹,

Kousaka²,

Jia³

et al. 2022

Nutrients

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Sarcopenia is the decline in skeletal muscle mass, strength, and functions, which decreases the quality of life in elderly people. This study investigated the suppressive effect of turmeric (Curcuma longa) extract (TE) on muscle atrophy in dexamethasone (DEX)-treated mice and C2C12 myotubes. DEX treatment significantly decreased the muscle weight and significantly increased Fbxo32 and Murf1 expression in mice, and these changes were suppressed by the supplementation of an AIN-93 based diet with 2% TE. A similar pattern was observed in FBXO32 and MuRF1 protein expression. In C2C12 myotubes, DEX treatment significantly increased FBXO32 and MuRF1 gene and protein expression, and these increases were significantly suppressed by TE supplementation at a concentration of 200 µg/mL. Furthermore, one of the five TE fractions, which were separated by high-performance liquid chromatography had a similar effect with TE supplementation. The present study proposes the suppressive effect of turmeric on sarcopenia.

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“…[57][58][59] The proportion of fast-twitch fibers has been reported to decrease with aging. 14,60,61 However, the proportion of fast-twitch fibers is thought to be greater in men than in women, and it is therefore thought that older men are more prone to the effects of aging than women. 62…”

Section: Age-related Changes In Muscle Mass and Functionmentioning

confidence: 99%

Skeletal muscle as a treatment target for older adults with diabetes mellitus: The importance of a multimodal intervention based on functional category

Omura

Araki

2022

Geriatrics Gerontology Int

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Although the lifespan of people with diabetes has increased in many countries, the age-related increase in comorbidities (sarcopenia, frailty and disabilities) and diabetic complications has become a major issue. Diabetes accelerates the aging of skeletal muscles and blood vessels through mechanisms, such as increased oxidative stress, chronic inflammation, insulin resistance, mitochondrial dysfunction, genetic polymorphism (fat mass and obesity-associated genes) and accumulation of advanced glycation end-products. Diabetes is associated with early onset, and progression of muscle weakness and sarcopenia, thus resulting in diminished daily life function. The type and duration of diabetes, insulin section/resistance, hyperglycemia, diabetic neuropathy, malnutrition and low physical activity might affect muscular loss and weakness. To prevent the decline in daily activities in older adults with diabetes, resistance training or multicomponent exercise should be recommended. To maintain muscle function, optimal energy and sufficient protein intake are necessary. Although no specific drug enhances muscle mass and function, antidiabetic drugs that increase insulin sensitivity or secretion could be candidates for improvement of sarcopenia. The goals of glycemic control for older patients are determined based on three functional categories through an assessment of cognitive function and activities of daily living, and the presence or absence of medications that pose a hypoglycemic risk. As these functional categories are associated with muscle weakness, frailty and mortality risk, providing multimodal interventions (exercise, nutrition, social network or support and optimal medical treatment) is important, starting at the category II stage for maintenance or improvement in daily life functions. Geriatr Gerontol Int 2022; 22: 110-120.

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Type-2 muscle fiber atrophy is associated with sarcopenia in elderly men with hip fracture

Cited by 24 publications

References 43 publications

Gene Ontology (GO)-Driven Inference of Candidate Proteomic Markers Associated with Muscle Atrophy Conditions

Gene Ontology (GO)-Driven Inference of Candidate Proteomic Markers Associated with Muscle Atrophy Conditions

Suppressive Effects of Turmeric Extract on Muscle Atrophy in Dexamethasone-Treated Mice and Myotubes

Skeletal muscle as a treatment target for older adults with diabetes mellitus: The importance of a multimodal intervention based on functional category

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