Type-1 Cannabinoid Receptor Signaling in Neuronal Development

Gaffuri, Anne-Lise; Ladarre, Delphine; Lenkei, Zsolt

doi:10.1159/000339075

Cited by 82 publications

(86 citation statements)

References 207 publications

(212 reference statements)

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“…As mentioned in this chapter, PUFA accretion in the brain occurs largely during brain development and our laboratory published many articles on the effects of imbalanced dietary PUFA during development on the adult brain [3,7,26]. In parallel, increasing evidence highlights that endocannabinoid signaling is essential for brain wiring [170,171]. Notably, endocannabinoids and CB1 receptors serve as guidance signals for axon cone growth [171].…”

Section: Perspectives: Implications For Future Therapeutics Of Endocamentioning

confidence: 99%

Dietary Omega-6/Omega-3 and Endocannabinoids: Implications for Brain Health and Diseases

Bosch‐Bouju¹,

Layé²

2016

Cannabinoids in Health and Disease

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Omega-3 (ω-3) and omega-6 (ω-6) are polyunsaturated fatty acids (PUFAs) that play critical role in human health and have to be provided by food. In the brain, PUFAs are also precursors of endocannabinoids. The aim of this chapter is to review the existing literature on how dietary PUFAs impact on the endocannabinoid system in the brain and what are the consequences for brain function and dysfunction. In this chapter, we will first describe how PUFAs enter the brain, what are their metabolism processes and roles in brain function. We will describe the pathways from PUFAs to endocannabinoid production. Then, we will review the literature on how dietary ω-6/ω-3 ratio impacts the endocannabinoid system, in terms of endocannabinoid levels, proteins and endocannabinoid-dependent synaptic plasticity. In the next part, we will describe what we know about the interactions between PUFAs and endocannabinoids in neurological and neuropsychiatric disorders. Finally, we will conclude on the possible implications of the interactions between dietary PUFAs and endocannabinoids in the normal and pathological brain. In particular, we will discuss how dietary PUFAs, as homeostatic regulators of endocannabinoids, can constitute interesting therapeutic strategies for the prevention and/or treatment of neurological disorders with endocannabinoids impairment.

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Section: Perspectives: Implications For Future Therapeutics Of Endocamentioning

confidence: 99%

Dietary Omega-6/Omega-3 and Endocannabinoids: Implications for Brain Health and Diseases

Bosch‐Bouju¹,

Layé²

2016

Cannabinoids in Health and Disease

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“…The CB1 receptor is expressed in the central nervous system and binds to Δ 9 -tetrahydrocannabinol (Δ 9 -THC), a component of marijuana, and induces psychiatric effects such as euphoria, hallucination, and analgesia (Gaffuri et al, 2012). On the other hand, the CB2 receptor, expressed in immunocompetent cells, is involved in regulation of immune responses (Atwood and Mackie, 2010).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of synthetic cannabinoids on CYP1A activity in mouse liver microsomes

et al. 2014

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-Synthetic cannabinoids developed by chemical modification are believed to bind to cannabinoid receptors and cause neurological effects similar to cannabis; however, their effects on drug metabolizing enzymes are unknown. This study aimed to elucidate the effect of synthetic cannabinoids on cytochrome P450 1A activity. Naphthoylindole, a basic structure of the major synthetic cannabinoids, strongly inhibited CYP1A activity in a competitive manner; the apparent Ki value was 0.40 μM. The N-Alkylated derivatives of naphthoylindole, MAM-2201 and JWH-019, also inhibited CYP1A activity in a concentration-dependent manner; however, their inhibitory effects were weaker than naphthoylindole. An adamantylamidoindole derivative, STS-135, showed inhibition of CYP1A activity in a concentrationdependent manner, but the adamantoylindole derivatives, AB-001 and AM-1248, did not. A tetramethylcyclopropanoylindole derivative, UR-144, showed a weak inhibition of CYP1A activity at high concentrations. These results suggest that synthetic cannabinoids and their basic molecules are capable of inhibiting CYP1A enzymatic activity.

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“…Estos cambios incluyen a la corteza prefrontal dorsolateral (Figura 3), la cual también está involucrada en la toma de decisiones (Long, Lind, Webster, & Weickert, 2012). La relevancia de estos cambios son en términos del desarrollo cerebral, ya que el receptor CB1 participa en la señalización para la diferenciación y la migración celular y, por lo mismo, para el establecimiento de redes neuronales (Gaffuri, Ladarre, & Lenkei, 2012). En este sentido, se ha sugerido que el consumo de mariguana en etapas anteriores a completar la maduración cerebral modifica la conectividad neuronal en la edad adulta, haciéndola más difusa y menos eficiente (Zalesky et al, 2012).…”

Section: Resultados Consumo De Mariguana Y Cambios Morfológicos En Elunclassified

Mariguana y sus efectos sobre el cerebro, la toma de decisiones y la inteligencia. Una revisión narrativa

Ruiz-Contreras¹,

Ortega-Mora²,

Belmont³

et al. 2016

RIIAD

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RESUMENIntroducción: la mariguana es la droga de mayor consumo después del tabaco y el alcohol, a pesar de que está penado utilizar más de cierto gramaje que depende del país; por ejemplo, en México es más de 5 g, lo que indica una alta motivación por conseguir la droga. Uno de los principios activos de la mariguana es el Δ9-tetrahidrocannabinol. Esta molécula afecta al sistema endocannabinoide, provocando cambios en su función y, concomitantemente, en la morfología cerebral. Objetivo: revisar y discutir la evidencia científica del efecto del consumo de mariguana sobre el cerebro, la inteligencia y la toma de decisiones. Método: se consideraron los reportes científicos que abarcan de 2005 a marzo de 2016 encontrados en PubMed, enfocados en los efectos del consumo de mariguana sobre cambios morfológicos cerebrales, la inteligencia y la toma de decisiones. Resultados: dependiendo de la edad de inicio del consumo de mariguana, es posible detectar cambios en el cerebro y la inteligencia, mientras que otras variables como la frecuencia o la cantidad de uso repercuten en la eficiencia para la toma de decisiones. Discusión y conclusiones: estos resultados señalan que 1) el consumo de mariguana afecta la morfología cerebral, la toma de decisiones y la inteligencia; 2) sugieren la potencial participación del sistema endocannabinoide en la toma de decisiones e inteligencia; y 3) dadas las consecuencias, deben alertar al sector salud para promover su prevención y en su momento estar preparados para la rehabilitación.Palabras clave: mariguana, inteligencia, adolescencia, sistema endocannabinoide, toma de decisiones. ABSTRACTIntroduction: marijuana or cannabis is the most consumed drug after tobacco and alcohol, even in the condition that to carry more than a given amount is a crime, suggesting that cannabis consumers are highly motivated to get the drug. In Mexico the amount allowed is 5g. Delta-9-tetrahydrocannabinol is one of the major psychoactive ingredient of cannabis. This molecule acts upon the endocannabinoid system, producing modifications in their function and, consequently, in the brain morphology. Objective: to review and discuss the scientific literature about cannabis consumption effect on brain, intelligence and decision-making. Method: the search of scientific reports in PubMed from January, 2005 to March, 2016, to evaluate the marijuana effect on brain morphology, intelligence and decision making. Results: it seems that as a function of the age of cannabis consumption onset the user might have morphological and functional brain changes, whereas variables such as frequency or amount of cannabis use may affect the efficiency of decision making. Discussion and conclusions: all these data together indicate that: 1) marijuana consumption affects brain morphology, decision-making and intelligence; 2) there is a potential role of the endocannabinoid system in decision-making and intelligence; and 3) given these consequences, should alert health organizations to develop strategies aiming prevention and if it is the...

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Type-1 Cannabinoid Receptor Signaling in Neuronal Development

Cited by 82 publications

References 207 publications

Dietary Omega-6/Omega-3 and Endocannabinoids: Implications for Brain Health and Diseases

Dietary Omega-6/Omega-3 and Endocannabinoids: Implications for Brain Health and Diseases

Inhibitory effect of synthetic cannabinoids on CYP1A activity in mouse liver microsomes

Mariguana y sus efectos sobre el cerebro, la toma de decisiones y la inteligencia. Una revisión narrativa

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