Tympanosclerosis

Otomicroscopic and histologic findings of induced myringosclerosis in rats: a critical study of an experimental model

“…It is a pathological process that is quite prevalent in our country because it is frequently detected in acute infections, especially chronic ME mucosa infections 1 , 9 . Despite the fact that they had been well defined in their histological characteristics 1 , 4 , 5 , 6 , 7 , 8 , etiology and pathogenesis are not completely explained and better understanding of these aspects may bring future possibilities of preventive treatment.…”

“…It is the final stage of a process originated from acute, chronic or recurrent inflammation of ME lamina propria, characterized by progressive infiltrate of fibroblasts, causing an increase in collagen, which originates poor formation of cells and blood vessels, followed by hyaline degeneration and in some occasions, calcium deposit 1 , 4 , 5 , 6 , 7 , which may lead to formation of cartilage or bone 8 . In some cases there may be functional damage for the tympanic-ossicle unit, causing conductive hearing loss, which affects surgical decisions during tympanoplasties.…”

Achados otomicroscópicos e histológicos da miringoesclerose induzida em ratos: estudo crítico de um modelo experimental

“…It is a pathological process that is quite prevalent in our country because it is frequently detected in acute infections, especially chronic ME mucosa infections 1,9 . Despite the fact that they had been well defined in their histological characteristics 1,[4][5][6][7][8] , etiology and pathogenesis are not completely explained and better understanding of these aspects may bring future possibilities of preventive treatment.…”

“…It is defined in the literature as hyaline degeneration that occurs in the collagen matrix that is formed during the repairing process, which can deposit calcium and phosphorus crystals. 1,[5][6][7] However, these deposits are not always present and the tympanosclerotic process may be characterized basically by hyalinization of neoformed collagen tissue of lamina propria and we considered as positive for myringosclerosis if there were phases 4 or 5 of the studied tissue.…”

“…It is the final stage of a process originated from acute, chronic or recurrent inflammation of ME lamina propria, characterized by progressive infiltrate of fibroblasts, causing an increase in collagen, which originates poor formation of cells and blood vessels, followed by hyaline degeneration and in some occasions, calcium deposit 1,[4][5][6][7] , which may lead to formation of cartilage or bone 8 . In some cases there may be functional damage for the tympanic-ossicle unit, causing conductive hearing loss, which affects surgical decisions during tympanoplasties.…”