Two‐Time Window and Multiangle Photon Correlation Spectroscopy Size and Zeta Potential Analysis — Highly Sensitive Rapid Assay for Dispersion Stability

Thode, Kai; Müller, Rainer H.; Kresse, Mayk

doi:10.1002/1520-6017(200010)89:10<1317::aid-jps9>3.0.co;2-g

Cited by 27 publications

(14 citation statements)

References 9 publications

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“…5) which assures the stability of colloidal nanoparticles. The positive values of zeta potential specify that the nanoparticles surface was positively charged which may be attributed due to presence of amino groups of chitosan on the surface of nanoparticles (Thode et al, 2000;Vila et al, 2004). Zeta Potential values greater than +20 mV or less than -20 mV typically have high degrees of stability.…”

Section: Resultsmentioning

confidence: 99%

Implementation of experimental design methodology in preparation and characterization of zolmitriptan loaded chitosan nanoparticles

Mandlik

Ranpise

2017

Int Curr Pharm J

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The present study investigated the implementation of 32 factorial design of experiment and statistical analysis for the optimization of chitosan nanoparticles containing zolmitriptan an antimigraine drug. The influence of chitosan concentration (X1) and sodium tripoly phosphate (X2) on responses namely nanoparticle size (Y1), and entrapment efficiency (Y2), was studied. As per design, nine runs of nanoparticles were prepared by modified ionic gelation method using high speed vortex mixing. The particle size was found in the range of 151-880 nm and entrapment efficiency was 72.3-81.2%. A statistical analysis was performed using licensed design expert software V.8.0 with respect to ANOVA, regression analysis. The contour plots and response surface plots showed visual representation of relationship between the experimental responses and the set of independent variables. Regression model equations were validated by a numerical and graphical optimization method. Further, optimized drug loaded nanoparticles showed +23.7mV zeta potential indicating storage stability, electron micrograph reflects spherical shape and mixed type of drug release followed by Fickian diffusion (n=0.266) was observed. Thus, using systematic factorial design approach, desirable goals can be achieved in shortest possible time with lesser number of experiments which was proven to be an effective tool in quality by design.Mandlik and Ranpise, International Current Pharmaceutical Journal, February 2017, 6(3): 16-22http://www.icpjonline.com/documents/Vol6Issue3/01.pdf

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Section: Resultsmentioning

confidence: 99%

Implementation of experimental design methodology in preparation and characterization of zolmitriptan loaded chitosan nanoparticles

Mandlik

Ranpise

2017

Int Curr Pharm J

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“…This can be tested, and to some extent predicted, by means of electrophoresis, which may be considered as a very useful tool in the investigation of the effectiveness of the surface modification employed in the situations referred to above. Another argument proving the significance of surface charge evaluation regards the biodistribution of nanocompounds in function of this quantity (u e ) measurements (Thode et al, 2000). Zeta potential titration permitted to confirm the pH value of about 7.5 for the isoelectric point of maghemite (Fig.…”

Section: Effects Of Ph and Ionic Strength On The Electrokineticmentioning

confidence: 89%

Maghemite Functionalization for Antitumor Drug Vehiculization

2012

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In this paper we describe the preparation and characterization of magnetic nanocomposites designed for applications in targeted drug delivery. Combining superparamagnetic behavior with proper surface functionalization in a single entity makes it possible to have altogether controlled location and drug loading, and release capabilities. The colloidal vehicles consist of maghemite (γ-Fe2O3) cores surrounded by a gold shell through an intermediate silica coating. The external Au layer confers the particles a high degree of biocompatibility and reactive sites for the transported drug binding. In addition, it permits to take advantage of the strong optical resonance, making it easy to visualize the particles or even control their payload release through temperature changes. The results of the analysis of relaxivity demonstrate that these nanostructures can be used as T 2 contrast agents in magnetic resonance imaging (MRI), but the magnetic cores will be mainly useful in manipulating the particles using external magnetic fields. We describe how optical absorbance and electrokinetic data provide a followup of the progress of the nanostructure formation. Additionally, these techniques, together with confocal microscopy, are employed to demonstrate that the component nanoparticles are capable of loading significant amounts of the antitumor drug doxorubicin, very efficient in the chemotherapy of a wide range of tumors. Colon adenocarcinoma cells were used to test the in vitro release capabilities of the drug-loaded nanocomposites.

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“…The mobility will depend on the effective charge on the surface. Zeta potential information is helpful in predicting the storage stability of colloidal dispersions (26). In general, greater the zeta potential value of a nanoparticulate system better is the colloidal suspension stability due to repulsion effect between charged nanoparticles.…”

Section: Effect Of Lyophilization On Polydispersity Index and Zeta Pomentioning

confidence: 99%

Modified Nanoprecipitation Method for Preparation of Cytarabine-Loaded PLGA Nanoparticles

2010

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Abstract. The present investigation was aimed at developing cytarabine-loaded poly(lactide-coglycolide) (PLGA)-based biodegradable nanoparticles by a modified nanoprecipitation which would have sustained release of the drug. Nine batches were prepared as per 3 2 factorial design to optimize volume of the cosolvent (0.22-0.37 ml) and volume of non-solvent (1.7-3.0 ml). A second 3 2 factorial design was used for optimization of drug: polymer ratio (1:5) and stirring time (30 min) based on the two responses, mean particle size (125±2.5 nm), and percentage entrapment efficiency (21.8±2.0%) of the Cyt-PLGA nanoparticles. Optimized formulation showed a zeta potential of −29.7 mV indicating good stability; 50% w/w of sucrose in Cyt-PLGA NP was added successfully as cryoprotectant during lyophilization for freeze-dried NPs and showed good dispersibility with minimum increase in their mean particle sizes. The DSC thermograms concluded that in the prepared PLGA NP, the drug was present in the amorphous phase and may have been homogeneously dispersed in the PLGA matrix. In vitro drug release from the pure drug was complete within 2 h, but was sustained up to 24 h from PLGA nanoparticles with Fickian diffusion. Stability studies showed that the developed PLGA NPs should be stored in the freeze-dried state at 2-8°C where they would remain stable in terms of both mean particle size and drug content for 2 months.

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Two‐Time Window and Multiangle Photon Correlation Spectroscopy Size and Zeta Potential Analysis — Highly Sensitive Rapid Assay for Dispersion Stability

Cited by 27 publications

References 9 publications

Implementation of experimental design methodology in preparation and characterization of zolmitriptan loaded chitosan nanoparticles

Implementation of experimental design methodology in preparation and characterization of zolmitriptan loaded chitosan nanoparticles

Maghemite Functionalization for Antitumor Drug Vehiculization

Modified Nanoprecipitation Method for Preparation of Cytarabine-Loaded PLGA Nanoparticles

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