Two strategies for coping with food shortage in desert golden spiny mice

Gutman, Roee; Yosha, Dotan; Choshniak, I.; Kronfeld‐Schor, Noga

doi:10.1016/j.physbeh.2006.08.033

Cited by 71 publications

(65 citation statements)

References 33 publications

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“…Starvation-induced hyperactivity in the first hour of night has already been observed in mouse lemurs (Genin and Perret, 2003;Giroud et al, 2008) and in other small vertebrates (Cornish and Mrosovsky, 1965;Sherwin, 1998). Under natural conditions, intense foraging or migratory behavior would increase the chances of survival of freeranging animals (Gutman et al, 2007).…”

Section: Discussionmentioning

confidence: 83%

Physiological flexibility and acclimation to food shortage in a heterothermic primate

Canale

Perret

Théry

et al. 2011

Journal of Experimental Biology

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SUMMARYAs ecosystems undergo changes worldwide, physiological flexibility is likely to be an important adaptive response to increased climate instability. Extreme weather fluctuations impose energetical constraints such as unpredictable food shortage. We tested how grey mouse lemurs (Microcebus murinus) could adjust their daily heterothermy and locomotor activity to these 'energetic accidents' with a food restriction experiment. The experimental design consisted of acute calorie restriction (2weeks, 80% restriction) in the middle of winter, after a fattening season with low (11weeks, 40% restriction) versus high (ad libitum) food availability. This design aimed at simulating the combined effects of the quality of the fattening season (acclimation effect) and a sudden, severe food shortage during the lean season. Hour of start and duration of torpor were the most flexible components of energy savings, increasing in response to the acute food shortage with facilitation by chronic restriction (acclimation effect). Modulations of locomotor activity did not support the hypothesis of energy savings, as total locomotor activity was not reduced. Nonetheless, acutely restricted individuals modified their temporal pattern of locomotor activity according to former food availability. We provide the first experimental evidence of different temporal levels of flexibility of energy-saving mechanisms in a heterotherm exposed to food shortage. The acclimation effect of past food scarcity suggests that heterothermic organisms are better able to respond to unpredicted food scarcity during the lean season. The flexible control of energy expenditure conferred by heterothermy may facilitate the plastic response of heterothermic species to more frequent climatic hazards. Supplementary material available online at

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Section: Discussionmentioning

confidence: 83%

Physiological flexibility and acclimation to food shortage in a heterothermic primate

Canale

Perret

Théry

et al. 2011

Journal of Experimental Biology

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“…Nevertheless, literature data about the impact of DR on EE and physical activity in rodents are not consistent and may comprise either reduced activity likely to save energy or hyper-activity, presumably due to increased food seeking. 30 The RER, which is a measure of the fuel substrate used in mitochondrial oxidation, was likewise decreased in the dark phase, averaging 0.7. This is indicative of increased fatty acid oxidation, supporting the assumption that DR mice reduced their physical activity in response to food shortage compared to AL mice.…”

Section: Discussionmentioning

confidence: 98%

Restriction on an Energy-Dense Diet Improves Markers of Metabolic Health and Cellular Aging in Mice Through Decreasing Hepatic mTOR Activity

Schloesser

Campbell

Glüer

et al. 2015

Rejuvenation Research

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Dietary restriction (DR) on a normal low-fat diet improves metabolic health and may prolong life span. However, it is still uncertain whether restriction of an energy-dense, high-fat diet would also be beneficial and mitigate age-related processes. In the present study, we determined biomarkers of metabolic health, energy metabolism, and cellular aging in obesity-prone mice subjected to 30% DR on a high-fat diet for 6 months. Dietary-restricted mice had significantly lower body weights, less adipose tissue, lower energy expenditure, and altered substrate oxidation compared to their ad libitum-fed counterparts. Hepatic major urinary proteins (Mup) expression, which is linked to glucose and energy metabolism, and biomarkers of metabolic health, including insulin, glucose, cholesterol, and leptin/adiponectin ratio, were likewise reduced in high-fat, dietary-restricted mice. Hallmarks of cellular senescence such as Lamp2a and Hsc70 that mediate chaperone-mediated autophagy were induced and mechanistic target of rapamycin (mTOR) signaling mitigated upon high-fat DR. In contrast to DR applied in low-fat diets, anti-oxidant gene expression, proteasome activity, as well as 5¢-adenosine monophosphate-activated protein kinase (AMPK) activation were not changed, suggesting that high-fat DR may attenuate some processes associated with cellular aging without the induction of cellular stress response or energy deprivation.

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“…U kolcomyszy złotawej Acomys russatus, zamieszkującej skaliste pustynie Bliskiego Wschodu, nie obserwuje się ani hibernacji, ani gromadzenia pożywienia zimą, ponieważ główny pokarm tego gatunku stanowią stawonogi. Zwierzęta te albo zapadają w torpor, albo zwiększają swoją aktywność w poszukiwaniu pokarmu (21). Przeprowadzono eksperyment, w którym o połowę zmniejszono dzienną dawkę pokarmu podawanego tym myszom, a następnie zmierzono stężenie leptyny w ich osoczu zarówno podczas głodówki, jak i po jej zakończeniu, gdy zwierzęta przybierały na wadze.…”

Section: Leptynooporność U Zwierzątunclassified

Physiological leptin resistance

Gogga¹,

Karbowska²,

Meissner³

et al. 2016

Medycyna Weterynaryjna

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Leptin is an adipose tissue-derived hormone whose circulating levels correlate with the amount of body fat stores. The main function of this adipokine is to regulate energy metabolism. By modulating the expression of orexigenic and anorexigenic neuropeptides in the hypothalamus, leptin reduces appetite. It also increases energy expenditure, contributing to the decrease of body fat and body weight. Mutations in the leptin receptor gene or prolonged consumption of a high-fat diet may impair leptin action, leading to leptin resistance. Resistance to leptin can also be an adaptive response that occurs in seasonal animals and in pregnant mammals. Reversible insensitivity to the satiety signal of leptin promotes hyperphagia, which is essential for animals living in dynamic environments and experiencing seasonal variation in food availability, since it allows them to forage intensely when food is abundant and accumulate fat reserves necessary to survive periods when food is scarce. Moreover, leptin resistance and subsequent hyperphagia develop during pregnancy in order to meet the energy needs of the growing fetus. Physiological leptin resistance may be due to impaired transport of leptin across the blood-brain barrier and/or to decreased sensitivity of the hypothalamus to this hormone resulting from an inhibition of leptin signalling in hypothalamic neurons. In pregnancy, an increased resistance to leptin action is also mediated by the binding of this adipokine to its placenta-derived soluble receptor. Reduced entry of leptin into the brain as well as alterations in the leptin signalling pathway in the hypothalamus leads to a transient decrease in sensitivity to this hormone preventing appetite suppression.

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Two strategies for coping with food shortage in desert golden spiny mice

Cited by 71 publications

References 33 publications

Physiological flexibility and acclimation to food shortage in a heterothermic primate

Physiological flexibility and acclimation to food shortage in a heterothermic primate

Restriction on an Energy-Dense Diet Improves Markers of Metabolic Health and Cellular Aging in Mice Through Decreasing Hepatic mTOR Activity

Physiological leptin resistance

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