Abstract:We proposed a novel pH measurement method based on two-photon fluorescence excitation of a dual-wavelength pHsensitive dye combined with scanning near-field optical microscopy (SNOM) that can be used to evaluate mitochondrial activity. Mitochondria produce ATP using a proton concentration (pH) gradient generated between both sides of their inner membrane. Thus, pH distribution around mitochondria can change with time when mitochondria produce ATP. This pH distribution has attracted interest because of its infl… Show more
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