In this paper, we provide a sufficient condition, in terms of the horizontal gradient of two horizontal velocity components and the gradient of liquid crystal molecular orientation field, for the breakdown of local in time strong solutions to the three‐dimensional incompressible nematic liquid crystal flows. More precisely, let T∗ be the maximal existence time of the local strong solution (u,d), then T∗<+∞ if and only if
∫0T∗∥∇huh∥Ḃp,2p30q+∥∇d∥Ḃ∞,∞02dt=∞with3p+2q=2,32