Two Lineages of Dengue Virus Type 2, Brazil

Oliveira, Michelli F.; Araújo, Josélio Maria Galvão de; Ferreira, Orlando C.; Ferreira, Davis Fernandes; Lima, Dirce Bonfim de; Santos, Flávia Barreto dos; Schatzmayr, Hermann G.; Tanuri, Amílcar; Nogueira, Rita Maria Ribeiro

doi:10.3201/eid1603.090996

Cited by 42 publications

(54 citation statements)

References 8 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is an important finding as DENV-2 in Brazil is related to severe disease [16], [17]. Co-infection with more than one DENV serotypes has been gradually reported in the last decade.…”

Section: Discussionmentioning

confidence: 69%

Clinical and Virological Descriptive Study in the 2011 Outbreak of Dengue in the Amazonas, Brazil

et al. 2014

View full text Add to dashboard Cite

BackgroundDengue is a vector-borne disease in the tropical and subtropical region of the world and is transmitted by the mosquito Aedes aegypti. In the state of Amazonas, Brazil during the 2011 outbreak of dengue all the four Dengue virus (DENV) serotypes circulating simultaneously were observed. The aim of the study was to describe the clinical epidemiology of dengue in Manaus, the capital city of the state of the Amazonas, where all the four DENV serotypes were co-circulating simultaneously.MethodologyPatients with acute febrile illness during the 2011 outbreak of dengue, enrolled at the Fundação de Medicina Tropical Dr. Heitor Viera Dourado (FMT-HVD), a referral centre for tropical and infectious diseases in Manaus, were invited to participate in a clinical and virological descriptive study. Sera from 677 patients were analyzed by RT-nested-PCRs for flaviviruses (DENV 1–4, Saint Louis encephalitis virus-SLEV, Bussuquara virus-BSQV and Ilheus virus-ILHV), alphavirus (Mayaro virus-MAYV) and orthobunyavirus (Oropouche virus-OROV).Principal FindingsOnly dengue viruses were detected in 260 patients (38.4%). Thirteen patients were co-infected with more than one DENV serotype and six (46.1%) of them had a more severe clinical presentation of the disease. Nucleotide sequencing showed that DENV-1 belonged to genotype V, DENV-2 to the Asian/American genotype, DENV-3 to genotype III and DENV-4 to genotype II.ConclusionsCo-infection with more than one DENV serotype was observed. This finding should be warning signs to health authorities in situations of the large dispersal of serotypes that are occurring in the world.

show abstract

“…This is an important finding as DENV-2 in Brazil is related to severe disease [16], [17]. Co-infection with more than one DENV serotypes has been gradually reported in the last decade.…”

Section: Discussionmentioning

confidence: 69%

Clinical and Virological Descriptive Study in the 2011 Outbreak of Dengue in the Amazonas, Brazil

et al. 2014

View full text Add to dashboard Cite

show abstract

“…genomic regions (5 0 -and 3 0 -untranslated regions, and E390) give a greater capacity for replication of this serotype, which has been associated with major epidemics in the Americas, with a high incidence of severe cases and mortality. 11,31,32,45 One limitation of this study is that it was based on data from passive epidemiological surveillance systems whose ability to identify cases of dengue (sensitivity) is low. Other studies have suggested that there is underreporting of mild cases of dengue and that severe cases are misclassified.…”

Section: Determinants Of Dengue Mortalitymentioning

confidence: 99%

Factors Associated with Dengue Mortality in Latin America and the Caribbean, 1995–2009: An Ecological Study

Díaz-Quijano

Waldman²

2012

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. In this study, we aimed to estimate the effect that environmental, demographic, and socioeconomic factors have on dengue mortality in Latin America and the Caribbean. To that end, we conducted an observational ecological study, analyzing data collected between 1995 and 2009. Dengue mortality rates were highest in the Caribbean (Spanishspeaking and non-Spanish-speaking). Multivariate analysis through Poisson regression revealed that the following factors were independently associated with dengue mortality: time since identification of endemicity (adjusted rate ratio ; population density (aRR = 2.1 and 3.2 for 20-120 inhabitants/km 2 and > 120 inhabitants/km 2 , respectively); Human Development Index > 0.83 (aRR = 0.4); and circulation of the dengue 2 serotype (aRR = 1.7). These results highlight the important role that environmental, demographic, socioeconomic, and biological factors have played in increasing the severity of dengue in recent decades.

show abstract

“…Esta variedad de DENV-2 se ha asociado a brotes explosivos con casos graves en la región amazónica de Brasil. (5) En este contexto epidemiológico, el presente reporte describe, según nuestro conocimiento, el primer caso de dengue neonatal documentado en el Perú, lo cual demuestra la transmisión vertical del DENV-2 tipificada en el producto de la gestación, destaca las enseñanzas relevantes para mejorar nuestro enfoque de diagnóstico y manejo de las gestantes y sus productos, con el objeto de prevenir casos similares durante brotes de dengue. …”

unclassified

Dengue neonatal en el Perú: Reporte de un caso

Delgado

Ríos²,

Barbarán³

et al. 2011

Rev Peru Med Exp Salud Publica

View full text Add to dashboard Cite

RESUMENSe presenta el caso de un neonato de sexo femenino, a término, producto de madre fallecida al séptimo día de su puerperio, por falla multiorgánica debido a dengue grave confirmado por detección de antígeno NS1 e IgM. La recién nacida (RN) no tuvo complicaciones, pero a partir del cuarto día de vida desarrolló fiebre, ictericia, manifestaciones de extravasación de plasma, hepatomegalia, ascitis, plaquetopenia y otros signos de síndrome de respuesta inflamatoria sistémica. Su evolución final fue favorable con tratamiento instaurado. Se demuestra con PCR en tiempo real, la presencia del virus dengue serotipo 2 en sangre de la RN, confirmándose el primer caso de dengue neonatal reportado en el Perú. NEONATAL DENGUE IN PERU : A CASE REPORT ABSTRACTWe present the case of a full-term female newborn, whose mother died seven days postpartum from multi-organ failure due to severe dengue confirmed by NS1 antigen detection and positive IgM. The newborn did not have any complication, but at the fourth day of life she developed fever, jaundice, signs of plasma leakage, thrombocytopenia, hepatomegaly, ascitis, and others signs of systemic inflammation response syndrome. She fully recovered with supportive treatment. The RT-PCR test of a peripheral blood sample revealed a positive result for the dengue virus serotype 2, confirming the first case of neonatal dengue reported in Peru. (1, 2) La curva endémica característica de cada año presenta un marcado incremento de casos entre la semana epidemiológica 42 hasta la semana 10 del siguiente año.(3) En las últimas semanas del año 2010 se declaró la epidemia de dengue en Iquitos al sobrepasar la zona de alerta del canal endémico. El Instituto Nacional de Salud de Perú (INS) evidenció la presencia del genotipo III del DENV-2, variante asiática-americana (4) lo que se correlacionó con el mayor reporte de casos de dengue grave y muertes que se notificaron en Iquitos en las primeras semanas de 2011. Esta variedad de DENV-2 se ha asociado a brotes explosivos con casos graves en la región amazónica de Brasil. (5) En este contexto epidemiológico, el presente reporte describe, según nuestro conocimiento, el primer caso de dengue neonatal documentado en el Perú, lo cual demuestra la transmisión vertical del DENV-2 tipificada en el producto de la gestación, destaca las enseñanzas relevantes para mejorar nuestro enfoque de diagnóstico y manejo de las gestantes y sus productos, con el objeto de prevenir casos similares durante brotes de dengue. PRESENTACIÓN DE CASORecién nacida de madre de 21 años, segundigesta y sin antecedentes patológicos de consideración. Cuatro días REPORTE DE CASO

show abstract

Two Lineages of Dengue Virus Type 2, Brazil

Cited by 42 publications

References 8 publications

Clinical and Virological Descriptive Study in the 2011 Outbreak of Dengue in the Amazonas, Brazil

Clinical and Virological Descriptive Study in the 2011 Outbreak of Dengue in the Amazonas, Brazil

Factors Associated with Dengue Mortality in Latin America and the Caribbean, 1995–2009: An Ecological Study

Dengue neonatal en el Perú: Reporte de un caso

Contact Info

Product

Resources

About