Two-generation reproduction study of lewisite in rats

Wildlife Toxicity Assessment for Lewisite

“…The subchronic study of lewisite in Sprague Dawley rats [11] identified the primary effect of lewisite to be necrotic lesions of the forestomach that occurred in animals receiving 1.0 mg/kg/day, equivalent to an average 7-day dose LOAEL of 0.71 mg/kg/day. The LOAEL may be consistent with that predicted to an average 7-day dose LOAEL of over 0.6 mg/kg/day from the 42-week, two-generation reproductive study [13,14] in which the high dose of 0.6 mg/kg/day failed to induce any overt toxic effects. In the subacute teratological study in Sprague Dawley rats and New Zealand white rabbits, rats showed reduction in fetal weights at the high-dose level of 2.0 mg/kg/day [12].…”

“…No effects level could be determined in rats as mortality was found in the F 0 generation [13,14]. Rats of each sex per group were gavaged with 0, 0.1, 0.25, or 0.6 mg lewisite/ kg/day in sesame oil, 5 days/week, for 13 weeks prior to mating.…”

“…Several toxicological studies [11][12][13][14] contain data relevant to the determination of lewisite toxicity reference values (TRVs). The subchronic study of lewisite in Sprague Dawley rats [11] identified the primary effect of lewisite to be necrotic lesions of the forestomach that occurred in animals receiving 1.0 mg/kg/day, equivalent to an average 7-day dose LOAEL of 0.71 mg/kg/day.…”

Arsenicals

“…In more serious cases of vapor intoxication, chest pain, nausea, vomiting, headache, weakness, convulsions, hypothermia, and hypotension occur (Sidell et al, 1997;Katos et al, 2007). Laboratory tests of the blood of persons exposed may show hemoconcentration; animal studies suggest elevated liver enzymes, including lactate dehydrogenase (LDH) (King et al, 1994;Sasser et al, 1999). The following sub-sections describe the effects on specific body sites.…”

Amended Safety Assessment of Sesamum Indicum (Sesame) Seed Oil, Hydrogenated Sesame Seed Oil, Sesamum Indicum (Sesame) Oil Unsaponifiables, and Sodium Sesameseedate

“…A 42-week 2-generation reproductive toxicity study on lewisite (chemical warfare agent) using parental male and female Sprague-Dawley rats and their offspring. 30 Vehicle control animals were given an In industry survey, no use concentrations reported for this category. c This category was combined when the original safety assessment was performed and is now more than one category.…”