2003
DOI: 10.1074/jbc.m303868200 View full text |Buy / Rent full text
|
|

Abstract: Globotriasosylceramide (Gb3), a neutral glycosphingolipid, is the B-cell differentiation antigen CD77 and acts as the receptor for most Shiga toxins, including verotoxin-1 (VT-1). We have shown that both anti-Gb3/ CD77 mAb and VT-1 induce apoptosis in Burkitt's lymphoma cells. We compared the apoptotic pathways induced by these two molecules by selecting cell lines sensitive to only one of these inducers or to both. In all these cell lines (including the apoptosis-resistant line), VT-1 was transported to the e… Show more

Help me understand this report

Search citation statements

Order By: Relevance
Select...
1
76
1

Publication Types

Select...

Relationship

0
0

Authors

Journals