2006
DOI: 10.1007/s10439-006-9194-5
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Abstract: A major drawback in the operation of mechanical heart valve prostheses is thrombus formation in the near valve region. Detailed flow analysis in this region during the valve closure phase is of interest in understanding the relationship between shear stress and platelet activation. A fixed-grid Cartesian mesh flow solver is used to simulate the blood flow through a bi-leaflet mechanical valve employing a two-dimensional geometry of the leaflet with a pivot point representing the hinge region. A local mesh refi… Show more

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Cited by 39 publications
(70 citation statements)
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References 58 publications
(74 reference statements)
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“…It can clarify how bulk flow within the valve orifice mechanically affects microscale flow within the complex hinge structures [83] with a level of detail that cannot be reached even with advanced experimental flow-measuring techniques. In addition, multiscale CFD models will also aid in computing the actual load imparted on the blood cells, as well as in investigating the mechanical interaction between red blood cells and platelets [108].…”
Section: Discussionmentioning
confidence: 99%
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“…It can clarify how bulk flow within the valve orifice mechanically affects microscale flow within the complex hinge structures [83] with a level of detail that cannot be reached even with advanced experimental flow-measuring techniques. In addition, multiscale CFD models will also aid in computing the actual load imparted on the blood cells, as well as in investigating the mechanical interaction between red blood cells and platelets [108].…”
Section: Discussionmentioning
confidence: 99%
“…In addition, multiscale CFD models will also aid in computing the actual load imparted on the blood cells, as well as in investigating the mechanical interaction between red blood cells and platelets [108]. This is particularly important in regions where the dimensions of the blood cells are comparable to the size of the flow geometry [83] and where non-Newtonian effects should be taken into account in the governing equations. Furthermore, knowledge of shear and pressure forces and resulting deformation is desirable to improve our insight into blood cell damage.…”
Section: Discussionmentioning
confidence: 99%
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“…The previous equations may appear to represent a rather limited setting for fluidstructure interaction problems, but in reality encompass a wide range of biologically relevant FSI problems. Examples include the deformation of cells [11][12][13], the pumping action of the heart [14], deformation of blood vessels [15], the operation of heart valves [16,17], locomotion of cells due to flagellar motion [18,19], and a host of others. The previous system of equations also provides a platform to examine general concepts and challenges associated with solving coupled fluid-structure interaction problems.…”
Section: Governing Equations and Important Parametersmentioning
confidence: 99%