Two differing presentations, treatments, and outcomes of malignant choroidal melanoma

Kearns, Carrie; Boyer, Stephen; Gay, Dax A.

doi:10.1016/j.optm.2007.10.009

Cited by 3 publications

(5 citation statements)

References 23 publications

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“…Women are slightly more affected than men and Whites have an eightfold increased risk than more darkly pigmented persons. [9] People with lightly colored irises have also increased risk to develop CM. [917] Prevalence increases with age as follows: 1 in 1 million before 30 years of age, 7 in 1 million before the age of 70 years, and 50 in 1 million after 70 years of age.…”

Section: Discussionmentioning

confidence: 99%

“…[9] People with lightly colored irises have also increased risk to develop CM. [917] Prevalence increases with age as follows: 1 in 1 million before 30 years of age, 7 in 1 million before the age of 70 years, and 50 in 1 million after 70 years of age. [69]…”

Section: Discussionmentioning

confidence: 99%

“…[1] The treatments include chemotherapy, brachytherapy, thermotherapy, and transpupillary enucleation. [9] The latter is historically the mainstay of treatment for CM. [3] COMS data published in 1998 showed no benefit on survival of patients with tumors of large size treated with radiotherapy before enucleation.…”

Section: Discussionmentioning

confidence: 99%

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Ocular melanoma: Keep your eyes open for late brain metastases

Silva

Matis²,

Costa³

et al. 2011

Surg Neurol Int

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Background:The most frequent intraocular malignant tumor is choroidal melanoma (CM). Although brain metastasis is a common feature of other types of cancers, metastasis of CM to the brain is a rare entity.Case Description:The authors report a case of a 28-year-old woman presenting with a single brain metastasis, 10 years after the treatment of a CM. She underwent a total en-bloc resection of the lesion, and the diagnosis was conﬁrmed histopathologically. The patient concomitantly received whole-brain irradiation therapy combined with chemotherapy, with a survival period of 24 months.Conclusion:The present case report draws attention to the necessity of a close and lifelong follow-up of patients treated for this malignancy. The international literature is also reviewed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Ocular melanoma: Keep your eyes open for late brain metastases

Silva

Matis²,

Costa³

et al. 2011

Surg Neurol Int

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“…Inflammation in the form of scleritis 118–121 , anterior uveitis 122–125 , posterior uveitis 126 , panuveitis 127 , and panophthalmitis 128–130 have been described with 22 (4.9%) of eyes in a series of 450 enucleated for uveal melanoma exhibiting some form of inflammation. 113, 131 In a large review of necrotic uveal melanomas from the Armed Forces Institute of Pathology, 75.1% of the 157 totally necrotic uveal melanomas in their registry presented with episcleritis and scleritis.…”

Section: Special Considerations Based On Infectious Etiologymentioning

confidence: 99%

“…131 In these atypical presentations of uveal melanoma, close follow up, serial photography, ultrasonography, and clinical suspicion are primarily employed. 118, 122, 123, 125, 126 In one case of ciliary body melanoma masquerading as chronic uveitis, multiple diagnostic vitrectomies were unrevealing to the diagnosis whereas serial ultrasound of a later identified ciliary body lesion was. 127 Tissue biopsy led to the diagnosis of two patients with uveal melanoma masquerading as scleritis.…”

Section: Special Considerations Based On Infectious Etiologymentioning

confidence: 99%

Diagnostic Vitrectomy for Infectious Uveitis

Jeroudi

Yeh

2014

International Ophthalmology Clinics

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The identification of an infectious or noninfectious uveitis syndrome is important to determine the range of therapeutic and prognostic implications of that disease entity. Diagnostic dilemmas arise with atypical history, atypical clinical presentations, inconclusive diagnostic workup, and persistent or worsened inflammation despite appropriate immunosuppression. More invasive intraocular testing is indicated in these situations particularly in infectious uveitis where a delay in treatment may result in worsening of the patient’s disease and a poor visual outcome. Laboratory analysis of vitreous fluid via diagnostic pars plana vitrectomy is an important technique in the diagnostic armamentarium, but the most important aspects of sample collection include rapid processing, close coordination with an ophthalmic pathology laboratory, and directed testing on this limited collected sample. Culture and staining has utility in bacterial, fungal, and nocardial infection. Polymerase chain reaction (PCR) analysis has shown promising results for bacterial endophthalmitis and infection with mycobacterium tuberculosis whereas PCR testing for viral retinitides and ocular toxoplasmosis has a more established role. Antibody testing is appropriate for toxoplasmosis and toxocariasis, and may be complementary to PCR for viral retinitis. Masquerade syndromes represent neoplastic conditions that clinically appear as infectious or inflammatory conditions and should be considered as part of the differential diagnosis. Diagnostic vitrectomy and chorioretinal biopsy are thus critical tools for the management of patients in whom an infectious etiology of uveitis is suspected.

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Unilateral acute angle closure glaucoma

et al. 2013

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SUMMARYA 52-year-old gentleman presented with 1-week history of severe right-sided headache associated with reduced vision in his right, amblyopic eye. Examination revealed raised intraocular pressure at 64 mm Hg. The anterior chamber (AC) was shallow and there was a dense cataract with no red reflex or fundal view. The contralateral eye had a deep anterior chamber with normal pressure and a clear lens. He was treated initially for acute angle closure glaucoma. The anterior chamber remained shallow and the intraocular pressure uncontrolled, despite maximum medical therapy. Owing to the absent fundal view and unilateral AC shallowing, further imaging was performed and a choroidal mass was found to be responsible for anterior displacement of the lens and shallowing of the angle. He went on to have an enucleation of the right eye, and histological examination confirmed the diagnosis of choroidal melanoma. BACKGROUND

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Two differing presentations, treatments, and outcomes of malignant choroidal melanoma

Cited by 3 publications

References 23 publications

Ocular melanoma: Keep your eyes open for late brain metastases

Ocular melanoma: Keep your eyes open for late brain metastases

Diagnostic Vitrectomy for Infectious Uveitis

Unilateral acute angle closure glaucoma

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